Abstract:
:Human epidermal growth factor 2 (HER2)+ breast cancer is considered the most dangerous type of breast cancers. Herein, we used bioinformatics methods to identify potential key genes in HER2+ breast cancer to enable its diagnosis, treatment, and prognosis prediction. Datasets of HER2+ breast cancer and normal tissue samples retrieved from Gene Expression Omnibus and The Cancer Genome Atlas databases were subjected to analysis for differentially expressed genes using R software. The identified differentially expressed genes were subjected to gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses followed by construction of protein-protein interaction networks using the STRING database to identify key genes. The genes were further validated via survival and differential gene expression analyses. We identified 97 upregulated and 106 downregulated genes that were primarily associated with processes such as mitosis, protein kinase activity, cell cycle, and the p53 signaling pathway. Visualization of the protein-protein interaction network identified 10 key genes (CCNA2, CDK1, CDC20, CCNB1, DLGAP5, AURKA, BUB1B, RRM2, TPX2, and MAD2L1), all of which were upregulated. Survival analysis using PROGgeneV2 showed that CDC20, CCNA2, DLGAP5, RRM2, and TPX2 are prognosis-related key genes in HER2+ breast cancer. A nomogram showed that high expression of RRM2, DLGAP5, and TPX2 was positively associated with the risk of death. TPX2, which has not previously been reported in HER2+ breast cancer, was associated with breast cancer development, progression, and prognosis and is therefore a potential key gene. It is hoped that this study can provide a new method for the diagnosis and treatment of HER2 + breast cancer.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Weng Y,Liang W,Ji Y,Li Z,Jia R,Liang Y,Ning P,Xu Ydoi
10.1177/1533033820983298subject
Has Abstractpub_date
2021-01-01 00:00:00pages
1533033820983298eissn
1533-0346issn
1533-0338journal_volume
20pub_type
杂志文章abstract::Endometrial carcinoma is one of the most common cancers in women. A limited number of endometrial carcinoma cell lines are available for studies of signal transduction pathways and experimental therapeutics in vitro. However, these cell lines have not been comprehensively characterized. In this study, we used genome-w...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303461000900207
更新日期:2010-04-01 00:00:00
abstract::This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460300200205
更新日期:2003-04-01 00:00:00
abstract::Optical methods such as reflectance and fluorescence spectroscopy are being investigated for their potential to aid cancer detection in a quantitative, minimally invasive manner. Mathematical models of reflectance and fluorescence provide an important link between measured optical data and biomedically-relevant tissue...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.7785/tcrt.2012.500187
更新日期:2011-04-01 00:00:00
abstract::A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. S...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460500400304
更新日期:2005-06-01 00:00:00
abstract::Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrtexpress.2013.600253
更新日期:2014-12-01 00:00:00
abstract::Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-media...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818785275
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To assess the efficacy of stereotactic body radiotherapy in patients with unresectable locally advanced pancreatic cancer. MATERIALS AND METHODS:All patients received a prescription dose of 45 Gy in 6 fractions. Primary end point was freedom from local progression. Secondary end points were overall survival, p...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616650778
更新日期:2017-06-01 00:00:00
abstract::We retrospectively reviewed factors that affected overall survival for patients with gynecological cancers that had metastasized to the brain. Between January 1985 to November 1999, we treated 25 patients with brain metastases from gynecological malignancies (cervix n=6, endometrium n=10, and ovary n=9). Various patie...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460200100412
更新日期:2002-08-01 00:00:00
abstract::The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two ye...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460600500307
更新日期:2006-06-01 00:00:00
abstract::We investigated the technique, early results and toxicity of curative stereotactic radiotherapy with the CyberKnife (Accuray Incorporated, Sunnyvale, California, USA) in 15 extracranial, extrapulmonary, extrahepatic, and extraspinal tumors. Fourteen tumors were located close to the bowel or esophagus. The PTV = GTV + ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460700600603
更新日期:2007-12-01 00:00:00
abstract::Numerous beam directions using 3-D conformal techniques can be employed in treating tumors in the posterior fossa, each with characteristic normal tissue exposure along the entrance and exit trajectory. A representative variety of beam configurations were modeled in a modern computer planning system initially with the...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460300200611
更新日期:2003-12-01 00:00:00
abstract::One of the most lethal carcinomas is pancreatic cancer. As standard treatment using chemotherapy and radiation has shown limited success, thermal regimens (cryotherapy or heat ablation) are emerging as viable alternatives. Although promising, our understanding of pancreatic cancer response to thermal ablation remains ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616655658
更新日期:2017-08-01 00:00:00
abstract::Proteomics is a rapidly expanding discipline that aims to gain a comprehensive understanding of the expressions, modification, interactions, and regulation of proteins in cells. New high-throughput technologies, such as protein chips and isotope-coded affinity tag peptide labeling, coupled with classic technologies su...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460200100402
更新日期:2002-08-01 00:00:00
abstract::In order to identify the proteomic differences between renal cell carcinoma (RCC) and benign renal tumors, we analyzed 168 serum samples from 65 RCC patients, 34 patients with benign renal tumors, and 69 healthy persons using the IMAC-Cu2+ ProteinChip system by surface enhanced laser desorption/ionization mass spectro...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460900800307
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Acute myeloid leukemia (AML) represents a hematological cancer. The aim of the investigation was to probe the regulatory relevance of long non-coding RNA (lncRNA) aspartyl-tRNA synthetase anti-sense 1 (DARS-AS1)/microRNA-425 (miR-425)/transforming growth factor-beta 1 (TGFB1) to the development of AML. METHO...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820965580
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We compared radiotherapy plans among helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), and intensity-modulated proton therapy (IMPT) for angiosarcoma of the scalp (AS). METHODS:We conducted a planning study for 19 patients with AS. The clinical target volume (CTV) 1 and CTV2 were defined as ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820985866
更新日期:2021-01-01 00:00:00
abstract::We have constructed a multimodal contrast agent suitable for near-infrared, NIR, fluorescent imaging as well as magnetic resonance imaging, MRI. This class of agents may be useful for preoperative tumor localization and tumor functional evaluation and for intraoperative delineation of tumor margins. We have covalently...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460600500401
更新日期:2006-08-01 00:00:00
abstract::Two noninvasive methods, thermography and laser Doppler imaging (LDI), were assessed for their ability to quantitatively assess parameters of vascularity in lesions of HIV-associated Kaposi's sarcoma (KS). Thermography and LDI images of a representative KS lesion were recorded in 16 patients and compared to normal ski...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460400300506
更新日期:2004-10-01 00:00:00
abstract::MicroRNAs are reported as a vital important factor in cancer cell initiation and progression processes. MicroRNA-19-3p has drawn the attention of many researchers in recent years because of its wide expression and its key role in serious kinds of tumor cells. However, the detailed mechanism of microRNA-19a-3p in these...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820917978
更新日期:2020-01-01 00:00:00
abstract::Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 has shown promise in cancer therapy. Due to the significant side effects of IL2, IL15 has been introduced into cancer therapy. A number of studies have suggested that ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500414
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To confirm the feasibility and accuracy of the method for evaluating blood supply and embolization rate of liver cancer based on I-flow software through animal experiments and clinical study. METHODS:Rabbits underwent selective angiography under different perfusion conditions in the same kidney. The blood su...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820970665
更新日期:2020-01-01 00:00:00
abstract::Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500181
更新日期:2011-02-01 00:00:00
abstract::The objective of this study is to compare the new and conventional tomotherapy treatment techniques and to evaluate dosimetric differences between them. A dosimetric analysis was performed by comparing planning target volume (PTV) median dose, 95% of PTV dose coverage, Paddick conformity index (CI), homogeneity index ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034614556932
更新日期:2015-08-01 00:00:00
abstract::Fascin is overexpressed in various tumor tissues and is closely related to tumor metastasis and invasion. However, the role of fascin in cholangiocarcinoma RBE cells has not been clearly reported. This study aimed to establish a cholangiocarcinoma cell line with stable and high expression of fascin to observe the effe...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615580696
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and toxicity of robotic CyberKnife (Accuray Incorporated, Sunnyvale, California)-based stereotactic body radiation therapy (SBRT) in patients with recurrent or metastatic abdominopelvic tumors. METHODS AND MATERIALS:A total of 69 patients treated between Ma...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615571353
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To evaluate 2 simultaneous integrated boost treatment planning techniques using helical tomotherapy for breast conserving therapy with regard to acute skin toxicity and dosimetry. METHODS:Thirty-two patients were studied. The original approach was for 16 patients and incorporated a directional block of the ips...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615574387
更新日期:2016-04-01 00:00:00
abstract::Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomic...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/1533033818782788
更新日期:2018-01-01 00:00:00
abstract::Brachytherapy has the advantage of delivering a high dose to the tumor while sparing the surrounding normal tissues. With proper case selection and delivery technique, high-dose-rate (HDR) brachytherapy has great promise, because it eliminates radiation exposure, allows short treatment times, and can be performed on a...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460400300305
更新日期:2004-06-01 00:00:00
abstract::For most basic radiobiological research applications involving irradiation of small animals, it is difficult to achieve the same high precision dose distribution realized with human radiotherapy. The precision for irradiations performed with standard radiotherapy equipment is +/-2 mm in each dimension, and is adequate...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460300200510
更新日期:2003-10-01 00:00:00
abstract::Helical tomotherapy is a form of image-guided intensity-modulated radiotherapy that introduces the ring gantry concept into radiation oncology. The system is a combination of a therapeutic linear accelerator and a megavoltage CT-scanner. This work describes the clinical experience with megavoltage CT with 456 patients...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460900800504
更新日期:2009-10-01 00:00:00