Abstract:
:The objective of this study is to compare the new and conventional tomotherapy treatment techniques and to evaluate dosimetric differences between them. A dosimetric analysis was performed by comparing planning target volume (PTV) median dose, 95% of PTV dose coverage, Paddick conformity index (CI), homogeneity index (HI), whole-body integral dose, and OAR median doses. The beam on time (BOT) and the effect of different jaw sizes and pitch values was studied. The study results indicated that the PTV dose coverage for all the techniques was comparable. Treatment plans using dynamic jaw reduced OAR doses to structures located at the treatment field edge compared to fixed jaw plans. The HT-3DCRT plans resulted in higher OAR doses to kidney, liver, and lung compared to the other techniques, and TD-IMRT provided the best dose sparing to liver compared to other techniques. Whole-body integral dose differences were found to be insignificant among the techniques. BOT was found to be higher for fixed jaw treatment plan compared to dynamic jaw plan and comparable between all treatment techniques with 5-cm dynamic jaw. In studying effect of jaw size, better OAR sparing and HI were found for 2.5-cm jaw but at the expense of doubling of BOT as compared to 5-cm jaw. There was no significant improvement found in OAR sparing when the pitch value was increased. Increasing the pitch from 0.2 to 0.43, the CI was improved, HI improved only for 5-cm jaw size, and BOT decreased to approximately half of its original time.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Zhang X,Penagaricano J,Han EY,Morrill S,Hardee M,Liang X,Gupta SK,Corry PM,Ratanatharathom Vdoi
10.1177/1533034614556932subject
Has Abstractpub_date
2015-08-01 00:00:00pages
440-6issue
4eissn
1533-0346issn
1533-0338pii
1533034614556932journal_volume
14pub_type
杂志文章abstract::Ionizing radiation therapy is one of the primary modalities for treating cancers. Ideally, the particle selected to deliver ionizing radiation for routine therapy should control the disease, cause minimal side effects, and be affordable. Two major properties for judging the utility of a particle, physical controllabil...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/15330346070060S406
更新日期:2007-08-01 00:00:00
abstract::Chemo-radiotherapy is standard treatment of stage IIIA-N2 bulky or IIIB non-small cell lung cancer (NSCLC). Surgical resection of residual disease in downstaged patients may improve overall survival. In this setting, restaging disease is still a challenge. 18F-FDG PET/CT represents the gold standard although accuracy ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500437
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abstract::Our study was designed to investigate the role of B4GalT1 in glioblastoma, in vitro and in vivo, to detect whether B4GalT1 knockdown could regulate the development of glioblastoma, and further observe the relationship between B4GalT1 knockdown and the apoptosis and autophagy of glioblastoma. To begin, we looked at TCG...
journal_title:Technology in cancer research & treatment
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abstract:OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title:Technology in cancer research & treatment
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doi:10.1177/1533033819892254
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abstract::One of the most lethal carcinomas is pancreatic cancer. As standard treatment using chemotherapy and radiation has shown limited success, thermal regimens (cryotherapy or heat ablation) are emerging as viable alternatives. Although promising, our understanding of pancreatic cancer response to thermal ablation remains ...
journal_title:Technology in cancer research & treatment
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doi:10.1177/1533034616655658
更新日期:2017-08-01 00:00:00
abstract::We retrospectively reviewed factors that affected overall survival for patients with gynecological cancers that had metastasized to the brain. Between January 1985 to November 1999, we treated 25 patients with brain metastases from gynecological malignancies (cervix n=6, endometrium n=10, and ovary n=9). Various patie...
journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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abstract::Proteomics is a rapidly expanding discipline that aims to gain a comprehensive understanding of the expressions, modification, interactions, and regulation of proteins in cells. New high-throughput technologies, such as protein chips and isotope-coded affinity tag peptide labeling, coupled with classic technologies su...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the mechanisms involved with miRNA-708 and its targeting of bone morphogenetic protein and activin membrane-bound inhibitor in cell proliferation, migration, and apoptosis in mice with melanoma via the Wnt and transforming growth factor β signaling pathways. METHODS:Sixt...
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更新日期:2018-01-01 00:00:00
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journal_title:Technology in cancer research & treatment
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abstract::Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...
journal_title:Technology in cancer research & treatment
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更新日期:2005-10-01 00:00:00
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrtexpress.2013.600253
更新日期:2014-12-01 00:00:00
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journal_title:Technology in cancer research & treatment
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更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Rectal cancer ranks as the eighth in cancer-related morbidity and the tenth in the cancer-related mortality. A few studies have explored several biomarkers for colorectal cancer. However, there is still a great need for us to excavate novel biomarkers with effective and efficient diagnostic and prognostic ...
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doi:10.1177/1533033820973270
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journal_title:Technology in cancer research & treatment
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更新日期:2010-04-01 00:00:00
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460800700204
更新日期:2008-04-01 00:00:00
abstract::We previously showed that microRNA-182 (miR-182) might promote cell proliferation and migration in triple-negative breast cancer (TNBC). This study aimed to investigate circular RNAs (circRNAs) that interact with miR-182 and play important roles in TNBC. Thirty patients with TNBC were enrolled. One pair of tumor and a...
journal_title:Technology in cancer research & treatment
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更新日期:2020-01-01 00:00:00
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journal_title:Technology in cancer research & treatment
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更新日期:2008-06-01 00:00:00
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journal_title:Technology in cancer research & treatment
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doi:10.1177/1533034615574387
更新日期:2016-04-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Technology in cancer research & treatment
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00