Abstract:
:Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomics, an emerging noninvasive technology using medical imaging analysis and data mining methodology, has been adopted to the area of cancer diagnostics in recent years. Its potential application in response assessment for cancer treatment has also drawn considerable attention. Radiomics seeks to extract a large amount of valuable information from patients' medical images (both pretreatment and follow-up images) and quantitatively correlate image features with diagnostic and therapeutic outcomes. Radiomics relies on computers to identify and analyze vast amounts of quantitative image features that were previously overlooked, unmanageable, or failed to be identified (and recorded) by human eyes. The research area has been focusing on the predictive accuracy of pretreatment features for outcome and response and the early discovery of signs of tumor response, recurrence, distant metastasis, radiation-induced lung injury, death, and other outcomes, respectively. This review summarized the application of radiomics in response assessments in radiotherapy and chemotherapy for non-small cell lung cancer, including image acquisition/reconstruction, region of interest definition/segmentation, feature extraction, and feature selection and classification. The literature search for references of this article includes PubMed peer-reviewed publications over the last 10 years on the topics of radiomics, textural features, radiotherapy, chemotherapy, lung cancer, and response assessment. Summary tables of radiomics in response assessment and treatment outcome prediction in radiation oncology have been developed based on the comprehensive review of the literature.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Shi L,He Y,Yuan Z,Benedict S,Valicenti R,Qiu J,Rong Ydoi
10.1177/1533033818782788subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1533033818782788eissn
1533-0346issn
1533-0338journal_volume
17pub_type
杂志文章,评审abstract::Spinal metastases are a common manifestation of malignant tumors that can cause severe pain, spinal cord compression, pathological fractures, and hypercalcemia, and these clinical manifestations will ultimately reduce the health-related quality of life and even shorten life expectancy in patient with cancer. Effective...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820945798
更新日期:2020-01-01 00:00:00
abstract::This successor phase II study evaluates the tolerability and efficacy of concomitant hyperfractionated radiation therapy (HFX-RT) and double dose intra-arterial (IA) cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). In doing so, this study represents further resurgence o...
journal_title:Technology in cancer research & treatment
pub_type: 临床试验,杂志文章
doi:10.1177/153303460200100206
更新日期:2002-04-01 00:00:00
abstract::The response of the tumor microvasculature to ionizing radiation can be modified to improve tumor control in preclinical mouse models of cancer. Recent studies have shown that a variety of cancer drugs can improve the response of cancers to radiotherapy. Protein tyrosine kinase inhibitors (TKIs) have been shown to enh...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460500400614
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and toxicity of robotic CyberKnife (Accuray Incorporated, Sunnyvale, California)-based stereotactic body radiation therapy (SBRT) in patients with recurrent or metastatic abdominopelvic tumors. METHODS AND MATERIALS:A total of 69 patients treated between Ma...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615571353
更新日期:2016-02-01 00:00:00
abstract::Traditional imaging techniques, such as computed tomography (CT), have high spatial resolution for changes in the anatomy or structure of organs, but are not very useful for detecting early biochemical changes. Conversely, positron emission tomography (PET) relies on changes in molecular biology to identify the earlie...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460600500204
更新日期:2006-04-01 00:00:00
abstract::We attempted to characterize the cellular autofluorescence phenomenon of living HL-60 cells and to appraise its modifications under oxidative stress conditions induced by 1 alpha,25(OH)(2)D(3) (VD(3)) and its analog EB1089. Autofluorescence emission spectra of human promyelocytic HL-60 leukemic cells were monitored us...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460400300409
更新日期:2004-08-01 00:00:00
abstract::The ultrasound-guided diffuse optical tomography is a noninvasive imaging technique for breast cancer diagnosis and treatment monitoring. The technique uses a handheld probe capable of providing measurements of multiple wavelengths in a few seconds. These measurements are used to estimate optical absorptions of lesion...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818802791
更新日期:2018-01-01 00:00:00
abstract::To describe the technological background, the accuracy, and clinical feasibility for single session lung radiosurgery using a real-time robotic system with respiratory tracking. The latest version of image-guided real-time respiratory tracking software (Synchrony, Accuray Incorporated, Sunnyvale, CA) was applied and i...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460700600409
更新日期:2007-08-01 00:00:00
abstract::This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460300200205
更新日期:2003-04-01 00:00:00
abstract::Our study was designed to investigate the role of B4GalT1 in glioblastoma, in vitro and in vivo, to detect whether B4GalT1 knockdown could regulate the development of glioblastoma, and further observe the relationship between B4GalT1 knockdown and the apoptosis and autophagy of glioblastoma. To begin, we looked at TCG...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820980104
更新日期:2020-01-01 00:00:00
abstract::As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not sat...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819892261
更新日期:2020-01-01 00:00:00
abstract::Helical tomotherapy is a form of image-guided intensity-modulated radiotherapy that introduces the ring gantry concept into radiation oncology. The system is a combination of a therapeutic linear accelerator and a megavoltage CT-scanner. This work describes the clinical experience with megavoltage CT with 456 patients...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460900800504
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:The aim of the in vivo dosimetry, during the fractionated radiation therapy, is the verification of the correct dose delivery to patient. Nowadays, in vivo dosimetry procedures for photon beams are based on the use of the electronic portal imaging device and dedicated software to elaborate electronic portal ima...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818779201
更新日期:2018-01-01 00:00:00
abstract::Lung carcinoma is the most frequently diagnosed malignancy in the world, with the incidence increasing through the 20th century. Presentation may be as a tumor mass primarily obstructing the central bronchial lumen, or a mass infiltrating lung tissue. Cryosurgery can be used as a method of palliative treatment for bot...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460400300207
更新日期:2004-04-01 00:00:00
abstract::Microwave imaging for medical applications has been of interest for many years. Recently, microwave imaging for breast cancer detection has gained attention due to advances in imaging algorithms, microwave hardware and computational power. The breast is relatively translucent to microwaves, accessible for imaging, and...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460500400110
更新日期:2005-02-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics of the disease. Standard uptake value (SUV) of [(18)F] Fluorodeoxyglucose (FDG) evaluated by phot...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500245
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:We recently developed a novel, open-source in vivo dosimetry that uses the electronic portal imaging device to detect dose delivery discrepancies. We applied our method on patients with rectal cancer treated on a belly board device. METHODS:In vivo dosimetry was performed on 10 patients with rectal cancer trea...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034617711519
更新日期:2017-12-01 00:00:00
abstract::Hydroxycamptothecin-encapsulated chitosan (HC) nanospheres were prepared by Shirasu porous glass (SPG) membrane emulsification technique. The properties and morphology of HC nanospheres were characterized. The diameter of the nanospheres could be controlled within a narrow distribution according to the pore-size of SP...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500404
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Neoadjuvant chemoradiotherapy (nCRT) followed by operation has become the standard treatment for locally advanced rectal cancer (LARC). However, considering the possible toxicity and complications of radiochemotherapy, nCRT is seldom used for the elderly. The purpose of this study was to assess the safety ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820970339
更新日期:2020-01-01 00:00:00
abstract::Optical methods such as reflectance and fluorescence spectroscopy are being investigated for their potential to aid cancer detection in a quantitative, minimally invasive manner. Mathematical models of reflectance and fluorescence provide an important link between measured optical data and biomedically-relevant tissue...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.7785/tcrt.2012.500187
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer. METHODS:The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the U...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820934133
更新日期:2020-01-01 00:00:00
abstract::This study quantifies the setup uncertainties to optimize the planning target volume (PTV) margin based on daily image guidance, its dosimetric impact, and radiobiological implication for intensity-modulated radiation therapy (IMRT) in head and neck cancer. Ten patients were retrospectively chosen who had been treated...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034614561162
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To evaluate a method for reducing metal artifacts, arising from dental fillings, on cone-beam computed tomography images. MATERIALS AND METHODS:A projection interpolation algorithm is applied to cone-beam computed tomography images containing metal artifacts from dental fillings. This technique involves identi...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615618319
更新日期:2016-12-01 00:00:00
abstract::Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking. Here, with th...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819869949
更新日期:2019-01-01 00:00:00
abstract::The purpose of this study was to evaluate the feasibility and treatment plans of intensity-modulated radiation therapy using helical tomotherapy (HT) for brain metastases. Twenty-three patients with 1 to 4 brain metastases were treated with HT. In combination with whole-brain radiotherapy (simultaneous plans), metasta...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460800700602
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,meta分析
doi:10.1177/1533033818791500
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:We compared radiotherapy plans among helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), and intensity-modulated proton therapy (IMPT) for angiosarcoma of the scalp (AS). METHODS:We conducted a planning study for 19 patients with AS. The clinical target volume (CTV) 1 and CTV2 were defined as ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820985866
更新日期:2021-01-01 00:00:00
abstract::The purpose of this research is to establish a process of irradiating mice using the Gamma Knife as a versatile system for small animal irradiation and to validate accurate intracranial and extracranial dose delivery using this system. A stereotactic immobilization device was developed for small animals for the Gamma ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616658394
更新日期:2017-04-01 00:00:00
abstract::Most experimental studies of electroporation focus on permeabilization of the outer cell membrane. Some experiments address delivery of ions and molecules into cells that should survive; others focus on efficient killing of the cells with minimal temperature rise. A basic method for quantifying electroporation effecti...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818792491
更新日期:2018-01-01 00:00:00
abstract::Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-media...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818785275
更新日期:2018-01-01 00:00:00