Abstract：
:We have constructed a multimodal contrast agent suitable for near-infrared, NIR, fluorescent imaging as well as magnetic resonance imaging, MRI. This class of agents may be useful for preoperative tumor localization and tumor functional evaluation and for intraoperative delineation of tumor margins. We have covalently attached dyes of the cyanine family to a previously described polymeric contrast agent, Gd-DTPA-polylysine, of an extended, uncoiled conformation. The dual modality agent is as effective in imaging tumors by MRI as the parent compound provided that the dye loading on the polymer is such that it does not eliminate all the available free-lysine groups on the parent Gd-DTPA-polylysine polymers. NIR fluorescence from preclinical subcutaneous and orthotopic mammary gland tumors could be detected with a signal to background ratio of as high as 4.5 at 12 hours post agent injection at a dye dose of 125 nmole/kg. For intraoperative delineation of tumor margins, a wide-field illumination camera system was devised giving high signal to background NIR fluorescent images of surgically exposed orthotopic mammary gland tumors. Histologic microscopy confirmed the location of the dual modality agent at the boundary of the tumor with a margin distance of about 0.3 mm from labeled tumor cells.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Uzgiris EE,Sood A,Bove K,Grimmond B,Lee D,Lomnes Sdoi
10.1177/153303460600500401subject
Has Abstractpub_date
2006-08-01 00:00:00pages
301-9issue
4eissn
1533-0346issn
1533-0338pii
d=3025&c=4209&p=15144&do=detailjournal_volume
5pub_type
杂志文章abstract：:Lung cancer remains one of the most common cancer-related deaths worldwide. The cigarette smoking is a risk factor for lung cancer development. Interestingly, the cystic fibrosis transmembrane conductance regulator encoded by CFTR gene, an ATP-binding cassette transporter-class ion channel that conducts chloride and b...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818809984
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer. METHODS:The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the U...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820934133
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:In this study, we aimed to evaluate the prognostic value of fluorodeoxyglucose uptake in the lung parenchyma and the presence of subclinical interstitial lung disease on computed tomography as predictive factors for survival following stereotactic body radiation therapy in patients with stage I non-small cell l...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818794934
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Antibody resistance, both de novo and acquired, is usually related to high risk of recurrence and lower survival rate in gynecologic cancers. Prevention or reversal of the resistance often yields beneficial clinical results. It was reported that anti-human epidermal growth factor receptor 3 monoclonal antibo...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615588422
更新日期：2016-08-01 00:00:00
abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics of the disease. Standard uptake value (SUV) of [(18)F] Fluorodeoxyglucose (FDG) evaluated by phot...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500245
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The blue laser imaging is a kind of new endoscopic system, sending 2 different wavelengths of laser. RESULT:It can observed that the gastrointestinal mucosa shallow capillaries and mucosal surface microstructure are shown in bright and high resolution images, thus being helpful to the diagnosis of early dig...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/1533033819825877
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Osteosarcoma is a common malignant bone tumor that is frequently found in the long bones of children and adolescents. The aim of this study is to examine long noncoding RNA-steroid receptor RNA activator 1 expression in osteosarcoma to explore the biological function of long noncoding RNA steroid receptor RNA...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819841438
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:We compared radiotherapy plans among helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), and intensity-modulated proton therapy (IMPT) for angiosarcoma of the scalp (AS). METHODS:We conducted a planning study for 19 patients with AS. The clinical target volume (CTV) 1 and CTV2 were defined as ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820985866
更新日期：2021-01-01 00:00:00
abstract：:This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460300200205
更新日期：2003-04-01 00:00:00
abstract：:We used a shifted-excitation Raman difference spectroscopy method for the ex vivo classification of resected and formalin-fixed breast tissue samples as normal (healthy) tissue, fibroadenoma, or invasive carcinoma. We analyzed 8 tissue samples containing invasive carcinoma that were surrounded by normal tissue and 3 t...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818782532
更新日期：2018-01-01 00:00:00
abstract：:This study was designed to estimate the risk of radiation-associated tumors and clinical toxicity in the brain following fractionated radiation treatment of pituitary adenoma. A standard case of a patient with a pituitary adenoma was planned using 8 different dosimetric techniques. Total dose was 50.4 Gy (GyE) at dail...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500199
更新日期：2011-06-01 00:00:00
abstract：:Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrtexpress.2013.600253
更新日期：2014-12-01 00:00:00
abstract：:Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 has shown promise in cancer therapy. Due to the significant side effects of IL2, IL15 has been introduced into cancer therapy. A number of studies have suggested that ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500414
更新日期：2015-10-01 00:00:00
abstract：:Proteomics is a rapidly expanding discipline that aims to gain a comprehensive understanding of the expressions, modification, interactions, and regulation of proteins in cells. New high-throughput technologies, such as protein chips and isotope-coded affinity tag peptide labeling, coupled with classic technologies su...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460200100402
更新日期：2002-08-01 00:00:00
abstract：:In recent years, the imaging of drug-induced apoptosis has become one of the centers of interest in experimental and clinical research. In particular, the accurate monitoring of chemosensitivity as well as the early prediction of chemoresistance in response to various pro-apoptotic interventions are critical requireme...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460400300103
更新日期：2004-02-01 00:00:00
abstract：:Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the targ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700507
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To confirm the feasibility and accuracy of the method for evaluating blood supply and embolization rate of liver cancer based on I-flow software through animal experiments and clinical study. METHODS:Rabbits underwent selective angiography under different perfusion conditions in the same kidney. The blood su...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820970665
更新日期：2020-01-01 00:00:00
abstract：:Microwave imaging for medical applications has been of interest for many years. Recently, microwave imaging for breast cancer detection has gained attention due to advances in imaging algorithms, microwave hardware and computational power. The breast is relatively translucent to microwaves, accessible for imaging, and...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460500400110
更新日期：2005-02-01 00:00:00
abstract：:Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400503
更新日期：2005-10-01 00:00:00
abstract：:The purpose of this research is to establish a process of irradiating mice using the Gamma Knife as a versatile system for small animal irradiation and to validate accurate intracranial and extracranial dose delivery using this system. A stereotactic immobilization device was developed for small animals for the Gamma ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616658394
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Our objective is to explore the accuracy of magnetic resonance imaging in determining the preoperative T and N staging, pathological stage, and the length of esophageal tumor in patients with esophageal cancer. METHODS:This retrospective analysis included 57 patients admitted to the Department of Thoracic S...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819876263
更新日期：2019-01-01 00:00:00
abstract：:The therapeutic utility of the anthracycline antibiotic doxorubicin is limited due to its cardiotoxicity. Our aim was to investigate the efficacy of fullerenol C(60)(OH)(24) in preventing single, high-dose doxorubicin-induced cardiotoxicity in rats with malignant neoplasm. Experiment was performed on adult female Spra...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700102
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819892254
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To evaluate 2 simultaneous integrated boost treatment planning techniques using helical tomotherapy for breast conserving therapy with regard to acute skin toxicity and dosimetry. METHODS:Thirty-two patients were studied. The original approach was for 16 patients and incorporated a directional block of the ips...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615574387
更新日期：2016-04-01 00:00:00
abstract：:Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400604
更新日期：2005-12-01 00:00:00
abstract：:Human epidermal growth factor 2 (HER2)+ breast cancer is considered the most dangerous type of breast cancers. Herein, we used bioinformatics methods to identify potential key genes in HER2+ breast cancer to enable its diagnosis, treatment, and prognosis prediction. Datasets of HER2+ breast cancer and normal tissue sa...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820983298
更新日期：2021-01-01 00:00:00
abstract：:We investigated the technique, early results and toxicity of curative stereotactic radiotherapy with the CyberKnife (Accuray Incorporated, Sunnyvale, California, USA) in 15 extracranial, extrapulmonary, extrahepatic, and extraspinal tumors. Fourteen tumors were located close to the bowel or esophagus. The PTV = GTV + ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460700600603
更新日期：2007-12-01 00:00:00
abstract：:Glypican-3 has been reported to be one of the most promising serum markers for hepatocellular carcinoma. This study aimed to assess the clinical utility of serum glypican 3 for the diagnosis of hepatocellular carcinoma. We recruited consecutive patients on a large scale, 283 with hepatocellular carcinoma, 445 with chr...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615605248
更新日期：2016-12-01 00:00:00
abstract：:This study aims to reduce the uncertainty about the photoneutron dose produced over a course of radiotherapy with high-energy photon beams and evaluate photoneutron contamination-based secondary malignancy risk for different treatment modalities. Dosimetric measurements were taken in Philips SL25/75, Elekta Synergy Pl...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615592106
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:Acute myeloid leukemia (AML) represents a hematological cancer. The aim of the investigation was to probe the regulatory relevance of long non-coding RNA (lncRNA) aspartyl-tRNA synthetase anti-sense 1 (DARS-AS1)/microRNA-425 (miR-425)/transforming growth factor-beta 1 (TGFB1) to the development of AML. METHO...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820965580
更新日期：2020-01-01 00:00:00
