DAB2IP Plays Important Clinical Significance and Correlates With Immune Infiltration in Renal Cell Carcinoma.

Abstract:

BACKGROUND:Disabled homolog 2-interacting protein is a new member of the Ras GTPase superfamily involved in the regulation of cell proliferation, apoptosis, and metastasis. However, the expression of disabled homolog 2-interacting protein in renal cell carcinoma, its correlation with cancer prognosis, and tumor infiltrating lymphocytes remains unclear. METHODS:The expression of disabled homolog 2-interacting protein was analyzed by UALCAN database, GEPIA database and the evaluation of disabled homolog 2-interacting protein effects on clinical prognosis. Prognostic factor analysis was used to identify the correlations between disabled homolog 2-interacting protein and cancer immune infiltration via the TIMER database. In addition, COXPRESdb database was used to analyze the enrichment of disabled homolog 2-interacting protein co-expression genes. RESULTS:Compared to the normal tissues, the messenger RNA expression levels of DAB2IP are higher in 8 while lower in 15 types of tumor tissues. Furthermore, disabled homolog 2-interacting protein has high expression in kidney chromophobe and low expression in both kidney renal clear cell carcinoma and kidney renal papillary cell carcinoma. The messenger RNA expression levels of disabled homolog 2-interacting protein decrease gradually due to the increasing tumor staging which positively correlates with disease-free survival and overall survival in both kidney renal clear cell carcinoma and kidney renal papillary cell carcinoma. The expression levels of disabled homolog 2-interacting protein also positively correlate with the tumor purity of kidney chromophobe, kidney renal clear cell carcinoma, and kidney renal papillary cell carcinoma samples. Besides, the expression of disabled homolog 2-interacting protein in renal cell carcinoma has negative correlation with the immune infiltration, and the immune infiltration of B cells and CD8+ T cells affects the prognosis of kidney renal papillary cell carcinoma. Enrichment analysis of disabled homolog 2-interacting protein co-expressed genes suggested that its biological role was mainly in regulating GTPase activity. CONCLUSIONS:These findings suggest that disabled homolog 2-interacting protein functions as a tumor suppressor in the progression of renal cell carcinoma, and the expression of disabled homolog 2-interacting protein is related to the immune infiltrating cells and affects the survival of renal cell carcinoma. Disabled homolog 2-interacting protein can be a novel clinical biomarker for patients with renal cell carcinoma, which also provides new insights for the future treatments of renal cell carcinoma.

authors

Cao H,Zhang J,Wang W

doi

10.1177/1533033820936682

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1533033820936682

eissn

1533-0346

issn

1533-0338

journal_volume

19

pub_type

杂志文章
  • Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.

    abstract::Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034617732426

    authors: Zhao S,Su G,Yang W,Yue P,Bai B,Lin Y,Zhang J,Ba Y,Luo Z,Liu X,Zhao L,Xie Y,Xu Y,Li S,Meng W,Xie X,Li X

    更新日期:2017-12-01 00:00:00

  • An Automated Preprocessing Method for Diffuse Optical Tomography to Improve Breast Cancer Diagnosis.

    abstract::The ultrasound-guided diffuse optical tomography is a noninvasive imaging technique for breast cancer diagnosis and treatment monitoring. The technique uses a handheld probe capable of providing measurements of multiple wavelengths in a few seconds. These measurements are used to estimate optical absorptions of lesion...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818802791

    authors: Althobaiti M,Vavadi H,Zhu Q

    更新日期:2018-01-01 00:00:00

  • Comparison of internal target volumes for hepatocellular carcinoma defined using 3DCT with active breathing coordinator and 4DCT.

    abstract::The aim of this paper is to study the feasibility for determining the individual internal target volume (ITV) for hepatocellular carcinoma (HCC) using 3DCT associated with active breathing coordinator (ABC), comparing the ITVs defined by 3DCT associated with ABC and 4DCT. Thirteen patients with HCC after transarterial...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303461101000610

    authors: Gong G,Yin Y,Xing L,Guo Y,Chen J,Liu T,Lu J,Ma C,Sun T,Bai T,Zhang G,Deng W

    更新日期:2011-12-01 00:00:00

  • Radiosurgery for glomus jugulare tumors.

    abstract::Results for treating glomus jugulare tumors with radiosurgery have been limited by short follow-up and small number of patients. We report our experience using LINAC or CyberKnife in 21 tumors with a median follow-up of 66 months (Mean follow-up of 60 months). In addition, we have a subset of eight patients that were ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460700600507

    authors: Lim M,Bower R,Nangiana JS,Adler JR,Chang SD

    更新日期:2007-10-01 00:00:00

  • Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis.

    abstract::Growing evidence suggests that aberration of the DNA repair pathway significantly contributes to tumorigenesis. Single-nucleotide polymorphisms in DNA repair-related genes such as WRN have been implicated in cancer risk. However, the results of published studies remain inconclusive. Therefore, we performed a meta-anal...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,meta分析

    doi:10.1177/1533034614561359

    authors: Wang B,Li G,Sun F,Dong N,Sun Z,Jiang D

    更新日期:2016-02-01 00:00:00

  • Metal Artifact Reduction in Cone-Beam Computed Tomography for Head and Neck Radiotherapy.

    abstract:PURPOSE:To evaluate a method for reducing metal artifacts, arising from dental fillings, on cone-beam computed tomography images. MATERIALS AND METHODS:A projection interpolation algorithm is applied to cone-beam computed tomography images containing metal artifacts from dental fillings. This technique involves identi...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615618319

    authors: Korpics M,Johnson P,Patel R,Surucu M,Choi M,Emami B,Roeske JC

    更新日期:2016-12-01 00:00:00

  • A Study on Stereoscopic X-ray Imaging Data Set on the Accuracy of Real-Time Tumor Tracking in External Beam Radiotherapy.

    abstract::At external beam radiotherapy, stereoscopic X-ray imaging system is responsible as tumor motion information provider. This system takes X-ray images intermittently from tumor position (1) at pretreatment step to provide training data set for model construction and (2) during treatment to control the accuracy of correl...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034616638803

    authors: Esmaili Torshabi A,Ghorbanzadeh L

    更新日期:2017-04-01 00:00:00

  • Comparison of BOLD cerebrovascular reactivity mapping and DSC MR perfusion imaging for prediction of neurovascular uncoupling potential in brain tumors.

    abstract::The coupling mechanism between neuronal firing and cerebrovascular dilatation can be significantly compromised in cerebral diseases, making it difficult to identify eloquent cortical areas near or within resectable lesions by using Blood Oxygen Level Dependent (BOLD) fMRI. Several metabolic and vascular factors have ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500284

    authors: Pillai JJ,Zacà D

    更新日期:2012-08-01 00:00:00

  • Models of light propagation in human tissue applied to cancer diagnostics.

    abstract::Optical methods such as reflectance and fluorescence spectroscopy are being investigated for their potential to aid cancer detection in a quantitative, minimally invasive manner. Mathematical models of reflectance and fluorescence provide an important link between measured optical data and biomedically-relevant tissue...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.7785/tcrt.2012.500187

    authors: Wilson RH,Mycek MA

    更新日期:2011-04-01 00:00:00

  • miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway.

    abstract:BACKGROUND:The incidence of nasopharyngeal carcinoma is increasing gradually, but the pathogenesis is not completely clear. MicroRNA, a highly conserved endogenous noncoding small molecule RNA, plays an essential role in the regulation of gene expression and is a hotspot in cancer research worldwide. OBJECTIVES:Althou...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819892251

    authors: Xuefang Z,Ruinian Z,Liji J,Chun Z,Qiaolan Z,Jun J,Yuming C,Junrong H

    更新日期:2020-01-01 00:00:00

  • Scanning time-domain optical mammography: detection and characterization of breast tumors in vivo.

    abstract::Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460500400503

    authors: Rinneberg H,Grosenick D,Moesta KT,Mucke J,Gebauer B,Stroszczynski C,Wabnitz H,Moeller M,Wassermann B,Schlag PM

    更新日期:2005-10-01 00:00:00

  • Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma.

    abstract:OBJECTIVE:Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may contribute to progress and metastasis of the cancers. The current ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820909911

    authors: Yu Y,Lin ZX,Li HW,Luo HQ,Yang DH,Zhou HC,Jiang DX,Zhan DC,Yang L,Liang XY,Yu ZH,Chen ZH

    更新日期:2020-01-01 00:00:00

  • Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.

    abstract:INTRODUCTION:Osteosarcoma is the most common primary tumor of bone, although some molecular markers have been identified, the detailed molecular mechanisms underlying osteosarcoma are currently not fully understood. In the present study, we attempted to identify the potential key genes and pathways in osteosarcoma usin...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820965605

    authors: Li Q,Liang J,Chen B

    更新日期:2020-01-01 00:00:00

  • Automatic Planning for Nasopharyngeal Carcinoma Based on Progressive Optimization in RayStation Treatment Planning System.

    abstract:OBJECTIVE:To evaluate and quantify the planning performance of automatic planning (AP) with manual planning (MP) for nasopharyngeal carcinoma in the RayStation treatment planning system (TPS). METHODS:A progressive and effective design method for AP of nasopharyngeal carcinoma was realized through automated scripts in...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820915710

    authors: Yang Y,Shao K,Zhang J,Chen M,Chen Y,Shan G

    更新日期:2020-01-01 00:00:00

  • A review of stereotactic radiosurgery in the management of brain metastases.

    abstract::This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460300200205

    authors: Sperduto PW

    更新日期:2003-04-01 00:00:00

  • Mechanism of MicroRNA-708 Targeting BAMBI in Cell Proliferation, Migration, and Apoptosis in Mice With Melanoma via the Wnt and TGF-β Signaling Pathways.

    abstract:OBJECTIVE:The aim of this study was to evaluate the mechanisms involved with miRNA-708 and its targeting of bone morphogenetic protein and activin membrane-bound inhibitor in cell proliferation, migration, and apoptosis in mice with melanoma via the Wnt and transforming growth factor β signaling pathways. METHODS:Sixt...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034618756784

    authors: Lu HJ,Yan J,Jin PY,Zheng GH,Zhang HL,Bai M,Wu DM,Lu J,Zheng YL

    更新日期:2018-01-01 00:00:00

  • Linear Accelerator-Based Radiotherapy Simulation Using On-Board Kilovoltage Cone-Beam Computed Tomography for 3-Dimensional Volumetric Planning and Rapid Treatment in the Palliative Setting.

    abstract:BACKGROUND:Palliation of advanced disease using radiotherapy can create difficult clinical situations where standard computed tomography simulation and immobilization techniques are not feasible. We developed a linear accelerator-based radiotherapy simulation technique using nonstandard patient positioning for head and...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819865623

    authors: Dyer BA,Nair CK,Deardorff CE,Wright CL,Perks JR,Rao SS

    更新日期:2019-01-01 00:00:00

  • Associations Between Apparent Diffusion Coefficient Value With Pathological Type, Histologic Grade, and Presence of Lymph Node Metastases of Esophageal Carcinoma.

    abstract:OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819892254

    authors: Wang Y,Bai G,Guo L,Chen W

    更新日期:2019-01-01 00:00:00

  • The performance of 17-gauge cryoprobes in vitro.

    abstract::In cryosurgery it is crucial that the performance of cryoprobes is predictable and constant. In this study we tested the intra- and interneedle variation between 17-gauge cryoprobes in two homogeneous mediums. Also, a multiprobe setup was tested. Cryoprobe performance was defined as the time it takes one cryoprobe to ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460800700406

    authors: Beemster PW,Lagerveld BW,Witte LP,de la Rosette JJ,Pes MP,Wijkstra H

    更新日期:2008-08-01 00:00:00

  • High dose rate brachytherapy: its clinical applications and treatment guidelines.

    abstract::Brachytherapy has the advantage of delivering a high dose to the tumor while sparing the surrounding normal tissues. With proper case selection and delivery technique, high-dose-rate (HDR) brachytherapy has great promise, because it eliminates radiation exposure, allows short treatment times, and can be performed on a...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460400300305

    authors: Nag S

    更新日期:2004-06-01 00:00:00

  • Anti-HER3 Monoclonal Antibody Inhibits Acquired Trastuzumab-Resistant Gynecologic Cancers.

    abstract:BACKGROUND:Antibody resistance, both de novo and acquired, is usually related to high risk of recurrence and lower survival rate in gynecologic cancers. Prevention or reversal of the resistance often yields beneficial clinical results. It was reported that anti-human epidermal growth factor receptor 3 monoclonal antibo...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615588422

    authors: Li X,Duan Y,Qiao C,Zhou T,Yu M,Geng J,Feng J,Shen B,Lv M,Li Y

    更新日期:2016-08-01 00:00:00

  • Novel advances in drug delivery to brain cancer.

    abstract::The therapy of brain tumors has been limited by a lack of effective methods of drug delivery to the brain. Systemic administration is often associated with toxic side effects and ultimately fails to achieve therapeutic concentrations within a tumor. An attractive strategy that has gained importance in brain tumor ther...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460500400409

    authors: Lesniak MS

    更新日期:2005-08-01 00:00:00

  • Modeling intracranial second tumor risk and estimates of clinical toxicity with various radiation therapy techniques for patients with pituitary adenoma.

    abstract::This study was designed to estimate the risk of radiation-associated tumors and clinical toxicity in the brain following fractionated radiation treatment of pituitary adenoma. A standard case of a patient with a pituitary adenoma was planned using 8 different dosimetric techniques. Total dose was 50.4 Gy (GyE) at dail...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500199

    authors: Winkfield KM,Niemierko A,Bussiere MR,Crowley EM,Napolitano BN,Beaudette KP,Loeffler JS,Shih HA

    更新日期:2011-06-01 00:00:00

  • Investigating the Stability of eLiposomes at Elevated Temperatures.

    abstract::eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor tissue. The purpose of this research is to show that eLiposomes synthesized using perfluoropenta...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034614551480

    authors: Husseini GA,Pitt WG,Javadi M

    更新日期:2015-08-01 00:00:00

  • Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current Trends and Controversies.

    abstract::Hepatocellular carcinoma is the fourth leading cause of cancer-related death worldwide. Depending on the extent of disease and competing comorbidities for mortality, multiple liver-directed therapy options exist for the treatment of hepatocellular carcinoma. Advancements in radiation oncology have led to the emergence...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/1533033818790217

    authors: Schaub SK,Hartvigson PE,Lock MI,Høyer M,Brunner TB,Cardenes HR,Dawson LA,Kim EY,Mayr NA,Lo SS,Apisarnthanarax S

    更新日期:2018-01-01 00:00:00

  • LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis.

    abstract:OBJECTIVE:Osteosarcoma is a common malignant bone tumor that is frequently found in the long bones of children and adolescents. The aim of this study is to examine long noncoding RNA-steroid receptor RNA activator 1 expression in osteosarcoma to explore the biological function of long noncoding RNA steroid receptor RNA...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819841438

    authors: Guo W,Jiang H,Li H,Li F,Yu Q,Liu Y,Jiang W,Zhang M

    更新日期:2019-01-01 00:00:00

  • Perineural invasion of squamous cell carcinoma of the lip with occult involvement of the infra-orbital nerve detected by PET-CT and treated with MRI-based IMRT: a case report.

    abstract::A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. S...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460500400304

    authors: Bhatnagar AK,Heron DE,Schaitkin B

    更新日期:2005-06-01 00:00:00

  • Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.

    abstract:OBJECTIVES:To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy. METHODS:Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was perfor...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615608739

    authors: Wimmer T,Srimathveeravalli G,Silk M,Monette S,Gutta N,Maybody M,Erinjery JP,Coleman JA,Solomon SB,Sofocleous CT

    更新日期:2016-12-01 00:00:00

  • Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma.

    abstract::Complement 3a (C3a) and complement 5a (C5a), small cleavage fragments generated by complement activation, has been previously shown to be obviously up-regulated in highly metastatic hepatocellular carcinoma (HCC) cells. However, their functional roles in HCC cells remains unclear. Here, we investigated the biological ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820970668

    authors: Chen B,Zhou W,Tang C,Wang G,Yuan P,Zhang Y,Bhushan SC,Ma J,Leng J

    更新日期:2020-01-01 00:00:00

  • Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.

    abstract::Lung cancer remains one of the most common cancer-related deaths worldwide. The cigarette smoking is a risk factor for lung cancer development. Interestingly, the cystic fibrosis transmembrane conductance regulator encoded by CFTR gene, an ATP-binding cassette transporter-class ion channel that conducts chloride and b...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818809984

    authors: Li H,Ma N,Wang J,Wang Y,Yuan C,Wu J,Luo M,Yang J,Chen J,Shi J,Liu X

    更新日期:2018-01-01 00:00:00