Abstract:
:The aim of this paper is to study the feasibility for determining the individual internal target volume (ITV) for hepatocellular carcinoma (HCC) using 3DCT associated with active breathing coordinator (ABC), comparing the ITVs defined by 3DCT associated with ABC and 4DCT. Thirteen patients with HCC after transarterial chemoembolization (TACE) treatment underwent 4DCT simulation and 3DCT simulation associated with ABC in free breathing (FB), end inspiration hold (EIH) and end expiration hold (EEH). The 4DCT images were sorted into 10 phases according to the respiratory cycle and labeled as CT(0), CT(10)...CT(90); and CT(MIP) (the maximum intensity projection image) was reconstructed. GTV(0), GTV(10)...GTV(90), GTV(MIP) on 4DCT, and the GTV(FB), GTV(EIH), GTV(EEH) on 3DCT were contoured. GTV(0,10...90), GTV(0) and GTV(50), GTV(EIH) and GTV(EEH) were merged into ITV(1), ITV(2) and ITV(3). The individual margins from GTV(FB) to ITV(1-3) were obtained and applied to ITV(FB) (labeled as ITV(FB-1), ITV(FB-2), ITV(FB-3)), respectively. All the target volumes were normalized by ITV(1). The volume of GTVs, ITVs and the margins were compared. There was no significant difference of diaphragm mobility between 4DCT and 3DCT (P > 0.05), nor significant difference among the volume of the GTVs. The three ITVs were larger than the GTV(MIP) (P < 0.05), but there was no significant difference among three ITVs. It's similar to the differences both in the margins of three dimensions from GTV(FB) to ITV(1-3) and in the volumes among ITV(FB-1), ITV(FB-2) and ITV(FB-3) (P > 0.05). This study shows that it's safe and feasible to determine the individual ITV for HCC using 3DCT associated with ABC in comparison with 4DCT.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Gong G,Yin Y,Xing L,Guo Y,Chen J,Liu T,Lu J,Ma C,Sun T,Bai T,Zhang G,Deng Wdoi
10.1177/153303461101000610subject
Has Abstractpub_date
2011-12-01 00:00:00pages
601-6issue
6eissn
1533-0346issn
1533-0338pii
c4318/Comparison-of-Internal-Target-Volumes-for-Hejournal_volume
10pub_type
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journal_title:Technology in cancer research & treatment
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abstract:BACKGROUND:The blue laser imaging is a kind of new endoscopic system, sending 2 different wavelengths of laser. RESULT:It can observed that the gastrointestinal mucosa shallow capillaries and mucosal surface microstructure are shown in bright and high resolution images, thus being helpful to the diagnosis of early dig...
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