Abstract：
:Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify the possible differentiation-related proteins which may be used for early diagnosis and more effective therapies. We compared poorly differentiated and well-differentiated hepatocellular carcinoma tissues by using 2-dimensional gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Among the 11 identified protein spots, 6 were found to be upregulated in poorly differentiated hepatocellular carcinoma tissues and 5 were correspondingly downregulated. Immunohistochemistry was performed on 106 hepatocellular carcinoma tissues to confirm the results of the proteomic analysis. By using bioinformatic tools GO and STRING, these proteins were found to be related to catalytic activity, binding, and antioxidant activity. In particular, our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein β-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Zhao S,Su G,Yang W,Yue P,Bai B,Lin Y,Zhang J,Ba Y,Luo Z,Liu X,Zhao L,Xie Y,Xu Y,Li S,Meng W,Xie X,Li Xdoi
10.1177/1533034617732426subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1092-1101issue
6eissn
1533-0346issn
1533-0338journal_volume
16pub_type
杂志文章abstract：:The purpose of the investigation was to assess positron emission tomography (PET), computed tomography (CT) and the image fusion of PET and CT (PET/CT) in the detection of metastases from gastrointestinal neuroendocrine tumors. In a prospective study, thirty-one patients were consecutively examined using a state-of-th...
journal_title：Technology in cancer research & treatment
pub_type： 临床试验,杂志文章
doi：10.1177/153303460700600309
更新日期：2007-06-01 00:00:00
abstract：:Gastric cancer is one of the most commonly occurring cancers worldwide. Investigation of long noncoding RNAs is of increasing interest, particularly in relation to their contribution to progression and prognosis of gastric cancers; however, insufficient studies been performed investigating the part of long noncoding R...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820930119
更新日期：2020-01-01 00:00:00
abstract：:Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the targ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700507
更新日期：2008-10-01 00:00:00
abstract：:Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA. Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fl...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034617753812
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer. METHODS:The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the U...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820934133
更新日期：2020-01-01 00:00:00
abstract：:This study aims to reduce the uncertainty about the photoneutron dose produced over a course of radiotherapy with high-energy photon beams and evaluate photoneutron contamination-based secondary malignancy risk for different treatment modalities. Dosimetric measurements were taken in Philips SL25/75, Elekta Synergy Pl...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615592106
更新日期：2016-08-01 00:00:00
abstract：:Microwave imaging for medical applications has been of interest for many years. Recently, microwave imaging for breast cancer detection has gained attention due to advances in imaging algorithms, microwave hardware and computational power. The breast is relatively translucent to microwaves, accessible for imaging, and...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460500400110
更新日期：2005-02-01 00:00:00
abstract：:Volumetric modulated arc therapy (VMAT) has been adopted by many clinics for its higher delivery efficiency compared to conventional intensity modulated radiotherapy techniques. Currently, the quality assurance (QA) has remained a challenge in that no identical tests are available for accelerators from different vendo...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034614500419
更新日期：2015-08-01 00:00:00
abstract：:The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two ye...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460600500307
更新日期：2006-06-01 00:00:00
abstract：:The accurate characterization and description of the vascular network of a cancer lesion is of paramount importance in clinical practice and cancer research in order to improve diagnostic accuracy or to assess the effectiveness of a treatment. The aim of this study was to show the effectiveness of liposomes as an ultr...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrtexpress.2013.600272
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Nonthermal irreversible electroporation is a minimally invasive surgery technology that employs high and brief electric fields to ablate undesirable tissues. Nonthermal irreversible electroporation can ablate only cells while preserving intact functional properties of the extracellular structures. Therefore,...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819876307
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Osteosarcoma is the most common primary tumor of bone, although some molecular markers have been identified, the detailed molecular mechanisms underlying osteosarcoma are currently not fully understood. In the present study, we attempted to identify the potential key genes and pathways in osteosarcoma usin...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820965605
更新日期：2020-01-01 00:00:00
abstract：:This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test an ANN model. Sensitivity analysis was then performed on the following operating conditions: ult...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460700600107
更新日期：2007-02-01 00:00:00
abstract：:Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrtexpress.2013.600253
更新日期：2014-12-01 00:00:00
abstract：:Intraoperative MRI (iMRI) is used in glioma surgery mainly to determine the extent of resection, allowing surgeons to immediately continue resection in case of residual tumor tissue. The aim of this study is to report on the influence of the use of iMRI on the extent of resection and survival of patients with glioblas...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900404
更新日期：2010-08-01 00:00:00
abstract：:We retrospectively reviewed factors that affected overall survival for patients with gynecological cancers that had metastasized to the brain. Between January 1985 to November 1999, we treated 25 patients with brain metastases from gynecological malignancies (cervix n=6, endometrium n=10, and ovary n=9). Various patie...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460200100412
更新日期：2002-08-01 00:00:00
abstract：:Despite remarkable progress in diagnosis and treatment, malignant glioma, a highly lethal cancer of the central nervous system, remains incurable. Although glioma stem-like cells (GSCs) represent a relatively small fraction of the cells in malignant glioma, they can proliferate and self renew extensively, being crucia...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500277
更新日期：2012-12-01 00:00:00
abstract：:A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. S...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400304
更新日期：2005-06-01 00:00:00
abstract：:To describe the technological background, the accuracy, and clinical feasibility for single session lung radiosurgery using a real-time robotic system with respiratory tracking. The latest version of image-guided real-time respiratory tracking software (Synchrony, Accuray Incorporated, Sunnyvale, CA) was applied and i...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460700600409
更新日期：2007-08-01 00:00:00
abstract：:Breast cancer remains one of the leading causes of cancer-associated death in women. MiR-27a is highly expressed in breast cancer tissue. However, the underlying mechanisms that promote breast cancer progression are unknown. In this study, we investigated the regulatory mechanisms of miR-27a and its target glycogen Sy...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820965576
更新日期：2020-01-01 00:00:00
abstract：:The coupling mechanism between neuronal firing and cerebrovascular dilatation can be significantly compromised in cerebral diseases, making it difficult to identify eloquent cortical areas near or within resectable lesions by using Blood Oxygen Level Dependent (BOLD) fMRI. Several metabolic and vascular factors have ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500284
更新日期：2012-08-01 00:00:00
abstract：:Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking. Here, with th...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819869949
更新日期：2019-01-01 00:00:00
abstract：:The purpose of this work is to estimate the degree of uncertainty inherent to a given four dimensional computed tomography (4D-CT) imaging modality and to test for interaction of the investigated factors (i.e., object displacement, velocity, and the period of motion) when determining the object motion coordinates, mot...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900309
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:Neoadjuvant chemoradiotherapy (nCRT) followed by operation has become the standard treatment for locally advanced rectal cancer (LARC). However, considering the possible toxicity and complications of radiochemotherapy, nCRT is seldom used for the elderly. The purpose of this study was to assess the safety ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820970339
更新日期：2020-01-01 00:00:00
abstract：:We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615626011
更新日期：2017-02-01 00:00:00
abstract：:Radiotherapy is frequently indicated to treat cerebral gliomas. Accurate response evaluation after radiotherapy is essential to determine the efficacy of treatment. We retrospectively analyzed the volumetric tumor response after simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in patients with...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500233
更新日期：2012-02-01 00:00:00
abstract：:This review addresses the epidemiology, historical reports, current issues, data and controversies involved in the management of brain metastases. The literature regarding surgery, whole brain radiation therapy, stereotactic radiosurgery or some combination of those treatments is discussed as well as issues of cost-ef...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460300200205
更新日期：2003-04-01 00:00:00
abstract：:The inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors. ING4 as a novel member of ING family has potential tumor-suppressive effects via multiple pathways. However, the therapeutic effect of adenovirus-mediated ING4 (Ad-ING4) gene transfer in human osteosarcoma is still unknown....
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500424
更新日期：2015-10-01 00:00:00
abstract：:Epithelial ovarian cancer has the highest mortality rate among the gynecologic cancers and spreads beyond the ovary in 90% of the women diagnosed with ovarian cancer. Detection before the disease has spread beyond the ovary would significantly improve the survival from ovarian cancer, which is currently only 30% over ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460400300612
更新日期：2004-12-01 00:00:00
abstract：:Optical methods such as reflectance and fluorescence spectroscopy are being investigated for their potential to aid cancer detection in a quantitative, minimally invasive manner. Mathematical models of reflectance and fluorescence provide an important link between measured optical data and biomedically-relevant tissue...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.7785/tcrt.2012.500187
更新日期：2011-04-01 00:00:00
