Abstract：
:Glypican-3 has been reported to be one of the most promising serum markers for hepatocellular carcinoma. This study aimed to assess the clinical utility of serum glypican 3 for the diagnosis of hepatocellular carcinoma. We recruited consecutive patients on a large scale, 283 with hepatocellular carcinoma, 445 with chronic hepatic diseases, and 162 normal controls, to assess the diagnostic accuracy of serum glypican 3 for hepatocellular carcinoma by enzyme-linked immunosorbent assay. In addition, we further analyzed the relationship between the serum levels of α-fetoprotein and glypican-3 in patients with hepatocellular carcinoma. The results indicated that serum glypican 3 was elevated in patients with hepatocellular carcinoma (0 ng/mL, range = 0-14.0 ng/mL, P = .033) and liver cirrhosis (0 ng/mL, range = 0-12.5 ng/mL, P = .001) compared to the levels in normal control (0 ng/mL, range = 0-4.3 ng/mL), but there was no difference between hepatocellular carcinoma and liver cirrhosis (P = .097). The area under the curve of the receiver-operating characteristics curve for hepatocellular carcinoma versus all controls was 0.519, with a sensitivity of 39.9%, a specificity of 60.6%, and an optimal cutoff value of 0.002 ng/mL. The positive and negative predictive values were 32.0% and 68.3%, respectively. No significant correlation in serum levels was observed between glypican 3 and α-fetoprotein (P > .05). The diagnostic sensitivity for hepatocellular carcinoma increased to 72.8% (206 of the 283) when glypican 3 was combined with α-fetoprotein. Glypican 3 was not a promising serum maker for the diagnosis of hepatocellular carcinoma alone, but it could be complementary to α-fetoprotein and elevate the sensitivity of hepatocellular carcinoma diagnosis.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Jia X,Gao Y,Zhai D,Liu J,Cai J,Wang Y,Jing L,Du Zdoi
10.1177/1533034615605248subject
Has Abstractpub_date
2016-12-01 00:00:00pages
780-786issue
6eissn
1533-0346issn
1533-0338pii
1533034615605248journal_volume
15pub_type
杂志文章abstract：:The role of salvage cryoablation of the prostate for patients with clinically localized prostate cancer that have failed radiotherapy to the prostate is reviewed with reference to alternatives including salvage radical prostatectomy and brachytherapy. The diagnosis and work-up of local recurrence/persistence of cancer...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460500400210
更新日期：2005-04-01 00:00:00
abstract：:We attempted to characterize the cellular autofluorescence phenomenon of living HL-60 cells and to appraise its modifications under oxidative stress conditions induced by 1 alpha,25(OH)(2)D(3) (VD(3)) and its analog EB1089. Autofluorescence emission spectra of human promyelocytic HL-60 leukemic cells were monitored us...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460400300409
更新日期：2004-08-01 00:00:00
abstract：:One of the most lethal carcinomas is pancreatic cancer. As standard treatment using chemotherapy and radiation has shown limited success, thermal regimens (cryotherapy or heat ablation) are emerging as viable alternatives. Although promising, our understanding of pancreatic cancer response to thermal ablation remains ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616655658
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the efficacy and toxicity of robotic CyberKnife (Accuray Incorporated, Sunnyvale, California)-based stereotactic body radiation therapy (SBRT) in patients with recurrent or metastatic abdominopelvic tumors. METHODS AND MATERIALS:A total of 69 patients treated between Ma...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615571353
更新日期：2016-02-01 00:00:00
abstract：:Intraoperative magnetic resonance imaging has been applied to a number of neurosurgical disease processes since the late 1990's. The ability to visualize the operative site in near-real time has added a significant degree of safety to the treatment of lesions such as a cystic craniopharyngioma which can be located in ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460300200103
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Disabled homolog 2-interacting protein is a new member of the Ras GTPase superfamily involved in the regulation of cell proliferation, apoptosis, and metastasis. However, the expression of disabled homolog 2-interacting protein in renal cell carcinoma, its correlation with cancer prognosis, and tumor infiltr...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820936682
更新日期：2020-01-01 00:00:00
abstract：:This study was performed to observe the effect of the combination of nimotuzumab with radiation or gemcitabine-based chemoradiation on antipancreatic cancer cell therapy. Pancreatic cancer cells (PANC-1) were treated with nimotuzumab alone or combined with radiation (2, 4, or 8 Gy), which was either with or without ge...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615585209
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Gene expression profiles from early-onset breast cancer and normal tissues were analyzed to explore the genes and prognostic factors associated with breast cancer. METHODS:GSE109169 and GSE89116 were obtained from the database of Gene Expression Omnibus. We firstly screened the differentially expressed gene...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819893670
更新日期：2020-01-01 00:00:00
abstract：:Endoscopic endonasal surgery (EES) has been shown to be a feasible approach to cranial base tumors while reducing post-operative morbidity. Using the endoscopic endonasal approach alone or in combination with open approaches may provide advantages over conventional approaches. However, the balance between maximal rese...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900507
更新日期：2010-10-01 00:00:00
abstract：:We describe the first histopathologic analysis of prostatic tissue following hypofractionated robotic radiation therapy. A 66 year-old man presented with stage II, low risk adenocarcinoma of the prostate and underwent elective conformal hypofractionated radiation therapy. His pretreatment evaluation revealed T1c adeno...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900606
更新日期：2010-12-01 00:00:00
abstract：AIM:To explore the relationship of clinicopathological features and the proteins of C-met expression in the prognosis of cholangiocarcinoma. METHODS:Clinical data and the completed follow-up information of patients with cholangiocarcinoma who underwent cholangiocarcinoma operation from January 2004 to December 2010 we...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615578959
更新日期：2016-04-01 00:00:00
abstract：:Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460500400503
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:The main objective in studying large-scale cancer omics is to identify molecular mechanisms of cancer and discover novel biomedical targets. This work not only discovers the cancer subtypes in genome scale data by using clustering and classification but also measures their accuracy. METHODS:Initially, candid...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818790509
更新日期：2018-01-01 00:00:00
abstract：:Spinal metastases are a common manifestation of malignant tumors that can cause severe pain, spinal cord compression, pathological fractures, and hypercalcemia, and these clinical manifestations will ultimately reduce the health-related quality of life and even shorten life expectancy in patient with cancer. Effective...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820945798
更新日期：2020-01-01 00:00:00
abstract：:Circular RNAs are a recently discovered subclass of endogenous noncoding RNAs that have been confirmed to play an important role in various pathophysiological processes. However, the underlying function of circular RNAs in osteosarcoma still remains unclear. We aimed to comprehend the function of circ_0032462 in osteo...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820943217
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:A meta-analysis was conducted to evaluate the diagnostic performance of contrast-enhanced ultrasonography using the contrast agent SonoVue to differentiate benign from malignant breast lesions. METHOD:A comprehensive search of the literature was performed using the Embase, PubMed, and Web of Science databases ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820971583
更新日期：2020-01-01 00:00:00
abstract：:Planning robotic radiosurgery treatments for multiple (n > 3) metastatic brain lesions is challenging due to the need of satisfying a large number of dose-volume constraints and the requirement of prescribing different dose levels to individual targets. In this study, we developed a sequential two-step optimization te...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500210
更新日期：2011-08-01 00:00:00
abstract：:This study aims to reduce the uncertainty about the photoneutron dose produced over a course of radiotherapy with high-energy photon beams and evaluate photoneutron contamination-based secondary malignancy risk for different treatment modalities. Dosimetric measurements were taken in Philips SL25/75, Elekta Synergy Pl...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615592106
更新日期：2016-08-01 00:00:00
abstract：:Intensity-modulated radiation therapy (IMRT) has gained rapid and wide-spread acceptance in the radiation oncology community for its ability to create dose distributions that conform to the convoluted shapes of many tumors. It is a complicated treatment technique, for which quality assurance procedures are correspondi...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460600500504
更新日期：2006-10-01 00:00:00
abstract：:The therapeutic utility of the anthracycline antibiotic doxorubicin is limited due to its cardiotoxicity. Our aim was to investigate the efficacy of fullerenol C(60)(OH)(24) in preventing single, high-dose doxorubicin-induced cardiotoxicity in rats with malignant neoplasm. Experiment was performed on adult female Spra...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700102
更新日期：2008-02-01 00:00:00
abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics of the disease. Standard uptake value (SUV) of [(18)F] Fluorodeoxyglucose (FDG) evaluated by phot...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500245
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819892254
更新日期：2019-01-01 00:00:00
abstract：:Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomic...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/1533033818782788
更新日期：2018-01-01 00:00:00
abstract：:Helical tomotherapy is a form of image-guided intensity-modulated radiotherapy that introduces the ring gantry concept into radiation oncology. The system is a combination of a therapeutic linear accelerator and a megavoltage CT-scanner. This work describes the clinical experience with megavoltage CT with 456 patients...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460900800504
更新日期：2009-10-01 00:00:00
abstract：:Non-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500181
更新日期：2011-02-01 00:00:00
abstract：:The efficacy of photodynamic therapy for the treatment of a large number of skin diseases, in particular non-malignant skin cancer, has been reported by a number of studies. It has been demonstrated to be particularly beneficial for large or multiple lesions, especially where good cosmesis is required. However for PDT...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460300200402
更新日期：2003-08-01 00:00:00
abstract：:The purpose of this research is to establish a process of irradiating mice using the Gamma Knife as a versatile system for small animal irradiation and to validate accurate intracranial and extracranial dose delivery using this system. A stereotactic immobilization device was developed for small animals for the Gamma ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034616658394
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Our objective is to explore the accuracy of magnetic resonance imaging in determining the preoperative T and N staging, pathological stage, and the length of esophageal tumor in patients with esophageal cancer. METHODS:This retrospective analysis included 57 patients admitted to the Department of Thoracic S...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819876263
更新日期：2019-01-01 00:00:00
abstract：:The integrated use of optical technologies for patient monitoring is addressed in the framework of time-resolved treatment delivery for scanned ion beam therapy. A software application has been designed to provide the therapy control system (TCS) with a continuous geometrical feedback by processing the external surrog...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrtexpress.2013.600275
更新日期：2014-12-01 00:00:00
abstract：:The purpose of this work is to estimate the degree of uncertainty inherent to a given four dimensional computed tomography (4D-CT) imaging modality and to test for interaction of the investigated factors (i.e., object displacement, velocity, and the period of motion) when determining the object motion coordinates, mot...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303461000900309
更新日期：2010-06-01 00:00:00
