Abstract：
:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeostasis. Stefin B-deficient mice were found more sensitive to lipopolysaccharide (LPS)-induced sepsis as a consequence of increased expression of caspase-11 and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing (NLRP nflammasome activation and higher levels of mitochondrial reactive oxygen species (ROS). In the present study, we investigated if LPS-triggered oxidative stress affected the protein levels and redox status of redox sensitive proteins-thioredoxin, peroxiredoxins, and superoxide dismutases in macrophages and spleens of LPS-injected mice. LPS challenge was found to result in a marked elevation in mitochondrial peroxiredoxin 3 (Prx3), sulfiredoxin, and superoxide dismutase 2 (Sod2) in stefin B-deficient macrophages and spleens. We determined that sulfiredoxin is targeted to mitochondria after LPS challenge. In conclusion, the upregulation of mitochondrial redox-sensitive proteins Prx3 and Sod2 in stefin B-deficient cells implies a protective role of stefin B in mitochondrial function.
journal_name
Cellsjournal_title
Cellsauthors
Trstenjak Prebanda M,Završnik J,Turk B,Kopitar Jerala Ndoi
10.3390/cells8121476subject
Has Abstractpub_date
2019-11-21 00:00:00issue
12issn
2073-4409pii
cells8121476journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA signature in HNSCC, both strands of the miR-99a-duplex (miR-99a-5p: the guide strand, and miR-99a-3p: the passen...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121535
更新日期：2019-11-28 00:00:00
abstract：:The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aqu...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091094
更新日期：2019-09-17 00:00:00
abstract：:The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9041005
更新日期：2020-04-17 00:00:00
abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091927
更新日期：2020-08-20 00:00:00
abstract：:Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate wit...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010173
更新日期：2020-01-10 00:00:00
abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040808
更新日期：2020-03-27 00:00:00
abstract：:The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010030
更新日期：2020-12-27 00:00:00
abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8020141
更新日期：2019-02-10 00:00:00
abstract：:Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they fa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091012
更新日期：2019-08-30 00:00:00
abstract：:The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092128
更新日期：2020-09-19 00:00:00
abstract：:The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids, are acknowledged to be a better model of the in viv...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030703
更新日期：2020-03-13 00:00:00
abstract：:Retinal neurons, particularly retinal ganglion cells (RGCs), are susceptible to the degenerative damage caused by different inherited conditions and environmental insults, leading to irreversible vision loss and, ultimately, blindness. Numerous strategies are being tested in different models of degeneration to restore...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081759
更新日期：2020-07-22 00:00:00
abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030537
更新日期：2020-02-26 00:00:00
abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051076
更新日期：2020-04-26 00:00:00
abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040984
更新日期：2020-04-16 00:00:00
abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010221
更新日期：2020-01-15 00:00:00
abstract：:The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro model. To directly assess the ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010045
更新日期：2019-01-12 00:00:00
abstract：:Breast cancer-related mortality remains high worldwide, despite tremendous advances in diagnostics and therapeutics; hence, the quest for better strategies for disease management, as well as the identification of modifiable risk factors, continues. With recent leaps in genomic technologies, microbiota have emerged as ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051091
更新日期：2020-04-28 00:00:00
abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051096
更新日期：2020-04-29 00:00:00
abstract：:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081785
更新日期：2020-07-27 00:00:00
abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010009
更新日期：2020-12-22 00:00:00
abstract：:The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080920
更新日期：2019-08-17 00:00:00
abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020247
更新日期：2014-04-04 00:00:00
abstract：:Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121483
更新日期：2019-11-21 00:00:00
abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020271
更新日期：2020-01-22 00:00:00
abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020337
更新日期：2020-02-01 00:00:00
abstract：:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121653
更新日期：2019-12-17 00:00:00
abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9092121
更新日期：2020-09-18 00:00:00
abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081815
更新日期：2020-07-31 00:00:00
abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080812
更新日期：2019-08-02 00:00:00
