Abstract：
:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninvasive biomarkers to improve early detection of this tumor. Liquid biopsy has emerged as a valuable tool in medical oncology which provides new horizons for improving clinical decision making. Notably, cell-free microRNAs (miRNAs), a class of short non-coding RNAs, are emerging as novel noninvasive cancer biomarkers. Here, we provide an overview of the potential clinical application of cell-free miRNAs as diagnostic, prognostic, and therapeutic biomarkers in oral cancer.
journal_name
Cellsjournal_title
Cellsauthors
Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MMdoi
10.3390/cells8121653subject
Has Abstractpub_date
2019-12-17 00:00:00issue
12issn
2073-4409pii
cells8121653journal_volume
8pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:For years, moderate hypothermia (32 °C) has been proposed as an unorthodox therapy for liver injuries, with proven hepatoprotective potential. Yet, limited mechanistic understanding has largely denied its acceptance over conventional pharmaceuticals for hepatoprotection. Today, facing a high prevalence of acetaminophe...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112354
更新日期：2020-10-26 00:00:00
abstract：:The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in C. elegans and mammalian cells. Since earlier research implicated H3K79me in pre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081846
更新日期：2020-08-06 00:00:00
abstract：:Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122579
更新日期：2020-12-02 00:00:00
abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080812
更新日期：2019-08-02 00:00:00
abstract：:Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070714
更新日期：2019-07-13 00:00:00
abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020379
更新日期：2020-02-06 00:00:00
abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050496
更新日期：2019-05-23 00:00:00
abstract：:Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction. The fact that INSR and IGF1R can function as transcription factors, capable of ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121499
更新日期：2019-11-23 00:00:00
abstract：:The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112475
更新日期：2020-11-13 00:00:00
abstract：:Hepatic fibrosis is the consequence of an unresolved wound healing process in response to chronic liver injury and involves multiple cell types and molecular mechanisms. The hepatic endocannabinoid and apelin systems are two signalling pathways with a substantial role in the liver fibrosis pathophysiology-both are upr...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8111311
更新日期：2019-10-24 00:00:00
abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030701
更新日期：2020-03-12 00:00:00
abstract：:Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030784
更新日期：2020-03-24 00:00:00
abstract：:The present Special Issue on "Cells in Cardiovascular Disease" wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory system [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9102192
更新日期：2020-09-29 00:00:00
abstract：:Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority. Still, our understanding of how disseminated cancer cells survive in the foreign metastatic environment, and eventually cause met...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010250
更新日期：2020-01-19 00:00:00
abstract：:Intestinal dysbiosis has recently become known as an important driver of gastrointestinal and liver disease. It remains poorly understood, however, how gastrointestinal microbes bypass the intestinal mucosa and enter systemic circulation to enact an inflammatory immune response. In the context of chronic liver disease...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8111324
更新日期：2019-10-27 00:00:00
abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060604
更新日期：2019-06-17 00:00:00
abstract：:Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030780
更新日期：2020-03-23 00:00:00
abstract：:Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010052
更新日期：2020-12-31 00:00:00
abstract：:The Hippo pathway is a cellular signalling network, which plays major roles in organ homeostasis and development[...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells8101179
更新日期：2019-09-30 00:00:00
abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121598
更新日期：2019-12-09 00:00:00
abstract：:Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060601
更新日期：2019-06-17 00:00:00
abstract：:Non-human primates (NHP) are important surrogate models for late preclinical development of advanced therapy medicinal products (ATMPs), including induced pluripotent stem cell (iPSC)-based therapies, which are also under development for heart failure repair. For effective heart repair by remuscularization, large numb...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061349
更新日期：2020-05-29 00:00:00
abstract：:Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020113
更新日期：2019-02-01 00:00:00
abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060543
更新日期：2019-06-05 00:00:00
abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110218
更新日期：2018-11-20 00:00:00
abstract：:Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in order to stimulate cel...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010171
更新日期：2020-01-09 00:00:00
abstract：:Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091068
更新日期：2019-09-11 00:00:00
abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091927
更新日期：2020-08-20 00:00:00
abstract：:NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood. We performed quantitative PCR (QPCR) arrays and bioinformatic analys...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020131
更新日期：2019-02-07 00:00:00
abstract：:Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020470
更新日期：2020-02-18 00:00:00
