Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...

journal_title：Cells

authors： Largeot A,Pagano G,Gonder S,Moussay E,Paggetti J

更新日期：2019-05-13 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

journal_title：Cells

authors： Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

更新日期：2020-02-04 00:00:00

abstract：:Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...

journal_title：Cells

authors： Gundamaraju R,Vemuri R,Chong WC,Myers S,Norouzi S,Shastri MD,Eri R

更新日期：2018-10-15 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in the excitation/inhibition balance (E/I ...

journal_title：Cells

authors： Dooves S,van Velthoven AJH,Suciati LG,Heine VM

更新日期：2021-01-12 00:00:00

abstract：:Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple sclerosis (MS), the most common inflammatory autoimmune disease of the CNS, leads to the destruction of myelin sheaths and the myelin-producing ol...

journal_title：Cells

authors： Gruchot J,Weyers V,Göttle P,Förster M,Hartung HP,Küry P,Kremer D

更新日期：2019-08-03 00:00:00

abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

journal_title：Cells

authors： Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

更新日期：2020-09-03 00:00:00

abstract：:Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...

journal_title：Cells

authors： Raasakka A,Kursula P

更新日期：2020-02-18 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...

journal_title：Cells

authors： Saccenti L,Hagiwara A,Andica C,Yokoyama K,Fujita S,Kato S,Maekawa T,Kamagata K,Le Berre A,Hori M,Wada A,Tateishi U,Hattori N,Aoki S

更新日期：2020-02-08 00:00:00

abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...

journal_title：Cells

authors： Khan S,Ricciardelli C,Yool AJ

更新日期：2021-01-22 00:00:00

abstract：:Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...

journal_title：Cells

authors： Cells Editorial Office

更新日期：2021-01-27 00:00:00

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivator...

journal_title：Cells

authors： Mittermeier C,Konopa A,Muehlich S

更新日期：2020-11-25 00:00:00

abstract：:Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...

journal_title：Cells

authors： Hannachi N,Lepidi H,Fontanini A,Takakura T,Bou-Khalil J,Gouriet F,Habib G,Raoult D,Camoin-Jau L,Baudoin JP

更新日期：2020-08-13 00:00:00

abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...

journal_title：Cells

authors： Kim YS,Choi J,Yoon BE

更新日期：2020-09-27 00:00:00

abstract：:Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes ...

journal_title：Cells

authors： Happé C,Kurakula K,Sun XQ,da Silva Goncalves Bos D,Rol N,Guignabert C,Tu L,Schalij I,Wiesmeijer KC,Tura-Ceide O,Vonk Noordegraaf A,de Man FS,Bogaard HJ,Goumans MJ

更新日期：2020-06-08 00:00:00

abstract：:Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...

journal_title：Cells

authors： Sousa L,Pankonien I,Clarke LA,Silva I,Kunzelmann K,Amaral MD

更新日期：2020-07-02 00:00:00

abstract：:In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there has been a great deal of progress in the implementation of EpCAM-based CTC detection technol...

journal_title：Cells

authors： Eslami-S Z,Cortés-Hernández LE,Alix-Panabières C

更新日期：2020-08-05 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...

journal_title：Cells

authors： Rutkowska E,Kwiecień I,Kulik K,Chełstowska B,Kłos K,Rzepecki P,Chciałowski A

更新日期：2021-01-06 00:00:00

abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...

journal_title：Cells

authors： Papiewska-Pająk I,Krzyżanowski D,Katela M,Rivet R,Michlewska S,Przygodzka P,Kowalska MA,Brézillon S

更新日期：2020-06-30 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have ...

journal_title：Cells

authors： Khavari B,Cairns MJ

更新日期：2020-08-05 00:00:00

abstract：:Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...

journal_title：Cells

authors： Štok U,Blokar E,Lenassi M,Holcar M,Frank-Bertoncelj M,Erman A,Resnik N,Sodin-Šemrl S,Čučnik S,Pirkmajer KP,Ambrožič A,Žigon P

更新日期：2020-05-13 00:00:00

abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...

journal_title：Cells

authors： Song W,Wang F,Chen L,Ma R,Zuo X,Cao A,Xie S,Chen X,Jin X,Li H

更新日期：2019-09-05 00:00:00

abstract：:Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...

journal_title：Cells

authors： Wang Q,Zhu Y,Zou X,Li F,Zhang J,Kang Z,Li X,Yin C,Lin Y

更新日期：2020-04-09 00:00:00

abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...

journal_title：Cells

authors： Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

更新日期：2020-04-04 00:00:00