Abstract:
:Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have been implicated in disease development and neuropathology, such as maternal immune infection, obstetric complications, childhood trauma and cannabis exposure. It is postulated that epigenetic factors, as well as regulatory non-coding RNAs, mediate the effects of these environmental stressors. In this review, we explore the most well-known epigenetic marks, including DNA methylation and histone modification, along with emerging RNA mediators of epigenomic state, including miRNAs and lncRNAs, and discuss their collective potential for involvement in the pathophysiology of schizophrenia implicated through the postmortem analysis of brain tissue. Given that peripheral tissues, such as blood, saliva, and olfactory epithelium have the same genetic composition and are exposed to many of the same environmental exposures, we also examine some studies supporting the application of peripheral tissues for epigenomic biomarker discovery in schizophrenia. Finally, we provide some perspective on how these biomarkers may be utilized to capture a signature of past events that informs future treatment.
journal_name
Cellsjournal_title
Cellsauthors
Khavari B,Cairns MJdoi
10.3390/cells9081837subject
Has Abstractpub_date
2020-08-05 00:00:00issue
8issn
2073-4409pii
cells9081837journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract::The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020278
更新日期:2020-01-23 00:00:00
abstract::Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells4030452
更新日期:2015-08-28 00:00:00
abstract::MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and n...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071574
更新日期:2020-06-28 00:00:00
abstract::The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112475
更新日期:2020-11-13 00:00:00
abstract::Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050507
更新日期:2019-05-26 00:00:00
abstract::Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061483
更新日期:2020-06-18 00:00:00
abstract::The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071697
更新日期:2020-07-15 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:Cells
pub_type: 已发布勘误
doi:10.3390/cells9102165
更新日期:2020-09-24 00:00:00
abstract::The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051076
更新日期:2020-04-26 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030704
更新日期:2020-03-13 00:00:00
abstract::CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010181
更新日期:2021-01-18 00:00:00
abstract::The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080920
更新日期:2019-08-17 00:00:00
abstract::Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic in...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061340
更新日期:2020-05-27 00:00:00
abstract::Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7100171
更新日期:2018-10-15 00:00:00
abstract::Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081831
更新日期:2020-08-04 00:00:00
abstract::Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121644
更新日期:2019-12-15 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases with an increasing prevalence due to rising rates of obesity, metabolic syndrome and type II diabetes. Untreated NAFLD may progress to steatohepatitis (NASH) and ultimately liver cirrhosis. NAFLD is characterized by lipid accumulatio...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061346
更新日期:2020-05-28 00:00:00
abstract::The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells1040774
更新日期:2012-10-15 00:00:00
abstract::The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spati...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020274
更新日期:2020-01-22 00:00:00
abstract::Alcoholic fatty liver disease (AFLD) is characterized by an abnormal accumulation of lipid droplets (LDs) in the liver. Here, we explore the composition of hepatic LDs in a rat model of AFLD. Five to seven weeks of alcohol consumption led to significant increases in hepatic triglyceride mass, along with increases in L...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7120230
更新日期:2018-11-24 00:00:00
abstract::Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020508
更新日期:2020-02-24 00:00:00
abstract::Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9041010
更新日期:2020-04-18 00:00:00
abstract::To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9092074
更新日期:2020-09-11 00:00:00
abstract::Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010144
更新日期:2021-01-12 00:00:00
abstract::Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs f...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020352
更新日期:2020-02-03 00:00:00
abstract::: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010114
更新日期:2020-01-02 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050488
更新日期:2019-05-22 00:00:00
abstract::In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8090954
更新日期:2019-08-22 00:00:00
abstract::The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051296
更新日期:2020-05-22 00:00:00
abstract::Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dy...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112348
更新日期:2020-10-23 00:00:00