Abstract：
:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological function of the central nervous system (CNS). In particular, glial cells undergo gliotransmission and regulate neuronal activity in tripartite synapses via ion channels (gap junction hemichannel, volume regulated anion channel, and bestrophin-1), receptors (for neurotransmitters and cytokines), or transporters (GLT-1, GLAST, and GATs) that are expressed on glial cell membranes. In this review, we propose that dysfunction in neuron-glia interactions may contribute to the pathogenesis of neurodevelopmental disorders. Understanding the mechanisms of neuron-glia interaction for synapse formation and maturation will contribute to the development of novel therapeutic targets of neurodevelopmental disorders.
journal_name
Cellsjournal_title
Cellsauthors
Kim YS,Choi J,Yoon BEdoi
10.3390/cells9102176subject
Has Abstractpub_date
2020-09-27 00:00:00issue
10issn
2073-4409pii
cells9102176journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:The blood-brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of ti...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040851
更新日期：2020-04-01 00:00:00
abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091039
更新日期：2019-09-05 00:00:00
abstract：:Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121483
更新日期：2019-11-21 00:00:00
abstract：:Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010025
更新日期：2019-01-07 00:00:00
abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050404
更新日期：2019-05-01 00:00:00
abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020247
更新日期：2014-04-04 00:00:00
abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030718
更新日期：2020-03-14 00:00:00
abstract：:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112528
更新日期：2020-11-23 00:00:00
abstract：:Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030592
更新日期：2020-03-02 00:00:00
abstract：:: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010114
更新日期：2020-01-02 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050488
更新日期：2019-05-22 00:00:00
abstract：:The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9041005
更新日期：2020-04-17 00:00:00
abstract：:During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020097
更新日期：2019-01-29 00:00:00
abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091927
更新日期：2020-08-20 00:00:00
abstract：:β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac fu...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010154
更新日期：2021-01-14 00:00:00
abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010085
更新日期：2021-01-07 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all synthesized as single-pass transmembrane proteins and bind polypeptide ligands, mainly growth factors. It has long been thought that...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020304
更新日期：2014-04-22 00:00:00
abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091087
更新日期：2019-09-14 00:00:00
abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050507
更新日期：2019-05-26 00:00:00
abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020288
更新日期：2014-04-09 00:00:00
abstract：:The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020500
更新日期：2020-02-22 00:00:00
abstract：:Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102185
更新日期：2020-09-28 00:00:00
abstract：:While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signali...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102236
更新日期：2020-10-03 00:00:00
abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010090
更新日期：2021-01-07 00:00:00
abstract：:Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8090993
更新日期：2019-08-28 00:00:00
abstract：:Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020386
更新日期：2014-05-06 00:00:00
abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9071694
更新日期：2020-07-15 00:00:00
abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122689
更新日期：2020-12-15 00:00:00
abstract：:Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/surv...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120263
更新日期：2018-12-11 00:00:00
abstract：:The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaini...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9071678
更新日期：2020-07-13 00:00:00
