Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma.

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：:Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...

journal_title：Cells

authors： Calistri A,Munegato D,Carli I,Parolin C,Palù G

更新日期：2014-05-06 00:00:00

abstract：:Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein ...

journal_title：Cells

authors： Gallego P,Castejón-Vega B,Del Campo JA,Cordero MD

更新日期：2020-09-23 00:00:00

abstract：:Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...

journal_title：Cells

authors： Saccenti L,Hagiwara A,Andica C,Yokoyama K,Fujita S,Kato S,Maekawa T,Kamagata K,Le Berre A,Hori M,Wada A,Tateishi U,Hattori N,Aoki S

更新日期：2020-02-08 00:00:00

abstract：:TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia. Here we investigated the role of TonEBP in acute kidney injury (AKI) using a line of TonEBP haplo-deficient mice s...

journal_title：Cells

authors： Yoo EJ,Lim SW,Kang HJ,Park H,Yoon S,Nam D,Sanada S,Kwon MJ,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2019-10-20 00:00:00

abstract：:Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...

journal_title：Cells

authors： Sabir N,Hussain T,Liao Y,Wang J,Song Y,Shahid M,Cheng G,Mangi MH,Yao J,Yang L,Zhao D,Zhou X

更新日期：2019-05-05 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...

journal_title：Cells

authors： Zaiou M

更新日期：2020-06-16 00:00:00

abstract：:Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic strategies has been constant. In this context, some cellular (enh...

journal_title：Cells

authors： Campos-Contreras ADR,Díaz-Muñoz M,Vázquez-Cuevas FG

更新日期：2020-07-03 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual...

journal_title：Cells

authors： Bylino OV,Ibragimov AN,Shidlovskii YV

更新日期：2020-07-12 00:00:00

abstract：:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...

journal_title：Cells

authors： Tang BL

更新日期：2018-06-14 00:00:00

abstract：:Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly underst...

journal_title：Cells

authors： Daignan-Fornier B,Pinson B

更新日期：2019-01-17 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

journal_title：Cells

authors： Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

更新日期：2019-06-30 00:00:00

abstract：:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...

journal_title：Cells

authors： Laganà M,Schlecht-Louf G,Bachelerie F

更新日期：2021-01-05 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...

journal_title：Cells

authors： Holmberg Olausson K,Nistér M,Lindström MS

更新日期：2012-10-15 00:00:00

abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...

journal_title：Cells

authors： Carotenuto P,Pecoraro A,Palma G,Russo G,Russo A

更新日期：2019-09-16 00:00:00

abstract：:Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a ma...

journal_title：Cells

authors： Negreiros-Lima GL,Lima KM,Moreira IZ,Jardim BLO,Vago JP,Galvão I,Teixeira LCR,Pinho V,Teixeira MM,Sugimoto MA,Sousa LP

更新日期：2020-01-06 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...

journal_title：Cells

authors： Lee Y,Kim SJ,Choo J,Heo G,Yoo JW,Jung Y,Rhee SH,Im E

更新日期：2020-06-01 00:00:00

abstract：:Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...

journal_title：Cells

authors： Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

更新日期：2020-12-03 00:00:00

abstract：:Although del Río-Hortega originally reported that leptomeningeal cells are the source of ramified microglia in the developing brain, recent views do not seem to pay much attention to this notion. In this study, in vitro experiments were conducted to determine whether leptomeninges generate ramified microglia. The lept...

journal_title：Cells

authors： Tanaka J,Takahashi H,Yano H,Nakanishi H

更新日期：2020-12-25 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...

journal_title：Cells

authors： Vaeteewoottacharn K,Pairojkul C,Kariya R,Muisuk K,Imtawil K,Chamgramol Y,Bhudhisawasdi V,Khuntikeo N,Pugkhem A,Saeseow OT,Silsirivanit A,Wongkham C,Wongkham S,Okada S

更新日期：2019-05-23 00:00:00

abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...

journal_title：Cells

authors： Berthelet J,Dubrez L

更新日期：2013-03-14 00:00:00

abstract：:Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...

journal_title：Cells

authors： Cells Editorial Office

更新日期：2021-01-27 00:00:00

abstract：:Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bac...

journal_title：Cells

authors： Zhou X,Yang G,Guan F

更新日期：2020-01-22 00:00:00

abstract：:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...

journal_title：Cells

authors： Huda N,Xu Y,Bates AM,Rankin DA,Kannan N,Gilley D

更新日期：2019-05-04 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

journal_title：Cells

authors： Rolot M,O'Sullivan TE

更新日期：2020-02-01 00:00:00