Abstract：
:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyglutamine (polyQ) repeat at HTT's N-terminus. Neuronal pathology in HD is largely due to the toxic gain-of-function by mHTT and its proteolytic products, which forms both nuclear and cytoplasmic aggregates that perturb nuclear gene transcription, RNA splicing and transport as well cellular membrane dynamics. The neuropathological effects of mHTT have been conventionally thought to be cell-autonomous in nature. Recent findings have, however, indicated that mHTT could be secreted by neurons, or transmitted from one neuronal cell to another via different modes of unconventional secretion, as well as via tunneling nanotubes (TNTs). These modes of transmission allow the intercellular spread of mHTT and its aggregates, thus plausibly promoting neuropathology within proximal neuronal populations and between neurons that are connected within neural circuits. Here, the various possible modes for mHTT's neuronal cell exit and intercellular transmission are discussed.
journal_name
Cellsjournal_title
Cellsauthors
Tang BLdoi
10.3390/cells7060059subject
Has Abstractpub_date
2018-06-14 00:00:00issue
6issn
2073-4409pii
cells7060059journal_volume
7pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:The blood-brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of ti...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040851
更新日期：2020-04-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060604
更新日期：2019-06-17 00:00:00
abstract：:Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a ma...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010128
更新日期：2020-01-06 00:00:00
abstract：:Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061473
更新日期：2020-06-16 00:00:00
abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010221
更新日期：2020-01-15 00:00:00
abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060618
更新日期：2019-06-20 00:00:00
abstract：:The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7070064
更新日期：2018-06-21 00:00:00
abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121627
更新日期：2019-12-12 00:00:00
abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020247
更新日期：2014-04-04 00:00:00
abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101133
更新日期：2019-09-24 00:00:00
abstract：:In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010063
更新日期：2021-01-03 00:00:00
abstract：:Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051102
更新日期：2020-04-29 00:00:00
abstract：:Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010016
更新日期：2020-12-24 00:00:00
abstract：:The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate b...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells5040042
更新日期：2016-11-24 00:00:00
abstract：:The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for bo...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102144
更新日期：2020-09-23 00:00:00
abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102173
更新日期：2020-09-26 00:00:00
abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081847
更新日期：2020-08-06 00:00:00
abstract：:Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081831
更新日期：2020-08-04 00:00:00
abstract：:Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9041010
更新日期：2020-04-18 00:00:00
abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9071694
更新日期：2020-07-15 00:00:00
abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092069
更新日期：2020-09-10 00:00:00
abstract：:Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and dif...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010025
更新日期：2020-12-25 00:00:00
abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050507
更新日期：2019-05-26 00:00:00
abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060625
更新日期：2019-06-21 00:00:00
abstract：:In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated a...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071581
更新日期：2020-06-29 00:00:00
abstract：:Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061422
更新日期：2020-06-08 00:00:00
abstract：:Parkinson's Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. Th...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8030222
更新日期：2019-03-07 00:00:00
abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020271
更新日期：2020-01-22 00:00:00
abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121476
更新日期：2019-11-21 00:00:00
abstract：:The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1040774
更新日期：2012-10-15 00:00:00
