Abstract：
:The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate basic ovarian functions (proliferation, apoptosis, secretory activity of ovarian cells, their response to upstream hormonal regulators, ovarian folliculo- and oogenesis, and fecundity). SIRTs and SIRTs-related signaling molecules and drugs regulating mTOR can be used for characterization, prediction, and regulation of ovarian functions, as well as for diagnostics and treatment of ovarian disorders.
journal_name
Cellsjournal_title
Cellsauthors
Sirotkin AVdoi
10.3390/cells5040042subject
Has Abstractpub_date
2016-11-24 00:00:00issue
4issn
2073-4409pii
cells5040042journal_volume
5pub_type
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