Glypican-1 Level Is Elevated in Extracellular Vesicles Released from MC38 Colon Adenocarcinoma Cells Overexpressing Snail.

abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...

journal_title：Cells

authors： Kolb K,Hellinger J,Kansy M,Wegwitz F,Bauerschmitz G,Emons G,Gründker C

更新日期：2020-12-05 00:00:00

abstract：:Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...

journal_title：Cells

authors： Huang Y,Yi X,Kang C,Wu C

更新日期：2019-10-16 00:00:00

abstract：:DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprin...

journal_title：Cells

authors： Borchiellini M,Ummarino S,Di Ruscio A

更新日期：2019-10-12 00:00:00

abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...

journal_title：Cells

authors： Umair M,Alfadhel M

更新日期：2019-12-09 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...

journal_title：Cells

authors： Sioud F,Amor S,Toumia IB,Lahmar A,Aires V,Chekir-Ghedira L,Delmas D

更新日期：2020-02-04 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative and inflammatory joint disorder with cartilage loss. Dental pulp stem cells (DPSCs) can undergo chondrogenic differentiation and secrete growth factors associated with tissue repair and immunomodulation. Leukocyte- and platelet-rich fibrin (L-PRF) emerges in regenerative medicine ...

journal_title：Cells

authors： Lo Monaco M,Gervois P,Beaumont J,Clegg P,Bronckaers A,Vandeweerd JM,Lambrichts I

更新日期：2020-04-15 00:00:00

abstract：:Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...

journal_title：Cells

authors： Ryskamp DA,Redmon S,Jo AO,Križaj D

更新日期：2014-09-12 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...

journal_title：Cells

authors： Zonta F,Borgo C,Quezada Meza CP,Masgras I,Rasola A,Salvi M,Pinna LA,Ruzzene M

更新日期：2021-01-18 00:00:00

abstract：:Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders are the leading causes of death and disability worldwide. Metabolic diseases cause vascular dysfunction and loss of capillaries termed capillary rarefaction. Interestingly, obesity seems to affect capillary beds in an organ-sp...

journal_title：Cells

authors： Paavonsalo S,Hariharan S,Lackman MH,Karaman S

更新日期：2020-12-14 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...

journal_title：Cells

authors： Erkilic N,Gatinois V,Torriano S,Bouret P,Sanjurjo-Soriano C,Luca V,Damodar K,Cereso N,Puechberty J,Sanchez-Alcudia R,Hamel CP,Ayuso C,Meunier I,Pellestor F,Kalatzis V

更新日期：2019-09-11 00:00:00

abstract：:Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstr...

journal_title：Cells

authors： Sarowar T,Grabrucker AM

更新日期：2020-08-26 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...

journal_title：Cells

authors： Nally FK,De Santi C,McCoy CE

更新日期：2019-06-05 00:00:00

abstract：:The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key proteins that generate (beta-secretase 1...

journal_title：Cells

authors： Buniatian GH,Weiskirchen R,Weiss TS,Schwinghammer U,Fritz M,Seferyan T,Proksch B,Glaser M,Lourhmati A,Buadze M,Borkham-Kamphorst E,Gaunitz F,Gleiter CH,Lang T,Schaeffeler E,Tremmel R,Cynis H,Frey WH 2nd,Gebhardt R,F

更新日期：2020-02-17 00:00:00

abstract：:Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

journal_title：Cells

authors： Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

更新日期：2020-02-24 00:00:00

abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...

journal_title：Cells

authors： Ji W,Rivero F

更新日期：2016-06-14 00:00:00

abstract：:Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its recepto...

journal_title：Cells

authors： Tang ZR,Zhang R,Lian ZX,Deng SL,Yu K

更新日期：2019-09-21 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where...

journal_title：Cells

authors： Xian J,Owusu Obeng E,Ratti S,Rusciano I,Marvi MV,Fazio A,De Stefano A,Mongiorgi S,Cappellini A,Ramazzotti G,Manzoli L,Cocco L,Follo MY

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. METHODS:This research was per...

journal_title：Cells

authors： Maués JHDS,Aquino Moreira-Nunes CF,Rodriguez Burbano RM

更新日期：2019-10-15 00:00:00

abstract：:A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...

journal_title：Cells

authors： Tröger J,Hoischen C,Perner B,Monajembashi S,Barbotin A,Löschberger A,Eggeling C,Kessels MM,Qualmann B,Hemmerich P

更新日期：2020-06-01 00:00:00

abstract：:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...

journal_title：Cells

authors： Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MM

更新日期：2019-12-17 00:00:00

abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

journal_title：Cells

authors： Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

更新日期：2019-12-28 00:00:00

abstract：:Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...

journal_title：Cells

authors： Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

更新日期：2020-12-03 00:00:00

abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...

journal_title：Cells

authors： Chiaradonna F,Ricciardiello F,Palorini R

更新日期：2018-06-02 00:00:00

abstract：:TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia. Here we investigated the role of TonEBP in acute kidney injury (AKI) using a line of TonEBP haplo-deficient mice s...

journal_title：Cells

authors： Yoo EJ,Lim SW,Kang HJ,Park H,Yoon S,Nam D,Sanada S,Kwon MJ,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2019-10-20 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00