MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks-A Review.

abstract：:Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...

journal_title：Cells

authors： Berger S,Gureczny S,Reisinger SN,Horvath O,Pollak DD

更新日期：2019-09-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...

journal_title：Cells

authors： Gowkielewicz M,Lipka A,Majewska M,Piotrowska A,Szadurska-Noga M,Nowakowski JJ,Wiszpolska M,Dzięgiel P,Wasniewski T,Majewski MK,Jozwik M

更新日期：2020-10-17 00:00:00

abstract：:In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...

journal_title：Cells

authors： Avalos-de León CG,Jiménez-Castro MB,Cornide-Petronio ME,Casillas-Ramírez A,Peralta C

更新日期：2019-12-09 00:00:00

abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...

journal_title：Cells

authors： Laferrière F,He X,Zinghirino F,Doudnikoff E,Faggiani E,Meissner WG,Bezard E,De Giorgi F,Ichas F

更新日期：2020-10-29 00:00:00

abstract：:Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles. Centrosomes serve as major microtubule- and actin cytoskeleton-organizing centers and are involved in a variety of intracellular pr...

journal_title：Cells

authors： Joukov V,De Nicolo A

更新日期：2019-07-10 00:00:00

abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...

journal_title：Cells

authors： Ferko M,Andelová N,Szeiffová Bačová B,Jašová M

更新日期：2019-11-17 00:00:00

abstract：:Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade ...

journal_title：Cells

authors： Choi Y,Heo SC,Kim YN,Joo JY,Hwang JJ,Bae MK,Kim HJ

更新日期：2020-12-31 00:00:00

abstract：:Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dy...

journal_title：Cells

authors： Peta C,Tsirimonaki E,Samouil D,Georgiadou K,Mangoura D

更新日期：2020-10-23 00:00:00

abstract：:During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...

journal_title：Cells

authors： Lorén CE,Dahl CP,Do L,Almaas VM,Geiran OR,Mörner S,Hellman U

更新日期：2019-01-29 00:00:00

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:Myelination of neuronal axons is essential for proper brain functioning and requires mature myelinating oligodendrocytes (myOLs). The human OL cell lines HOG and MO3.13 have been widely used as in vitro models to study OL (dys) functioning. Here we applied a number of protocols aimed at differentiating HOG and MO3.13 ...

journal_title：Cells

authors： De Kleijn KMA,Zuure WA,Peijnenborg J,Heuvelmans JM,Martens GJM

更新日期：2019-09-17 00:00:00

abstract：:Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...

journal_title：Cells

authors： Ryskamp DA,Redmon S,Jo AO,Križaj D

更新日期：2014-09-12 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...

journal_title：Cells

authors： Lee Y,Kim SJ,Choo J,Heo G,Yoo JW,Jung Y,Rhee SH,Im E

更新日期：2020-06-01 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...

journal_title：Cells

authors： Vital SA,Senchenkova EY,Ansari J,Gavins FNE

更新日期：2020-11-13 00:00:00

abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...

journal_title：Cells

authors： Palmerini E,Setola E,Grignani G,D'Ambrosio L,Comandone A,Righi A,Longhi A,Cesari M,Paioli A,Hakim R,Pierini M,Marchesi E,Vanel D,Pignochino Y,Donati DM,Picci P,Ferrari S

更新日期：2020-10-31 00:00:00

abstract：:The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

journal_title：Cells

authors： White S,Lin L,Hu K

更新日期：2020-05-29 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...

journal_title：Cells

authors： Howe HS,Leung BPL

更新日期：2019-12-27 00:00:00

abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...

journal_title：Cells

authors： Paolillo M,Colombo R,Serra M,Belvisi L,Papetti A,Ciusani E,Comincini S,Schinelli S

更新日期：2019-11-13 00:00:00

abstract：:Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this home...

journal_title：Cells

authors： Marino Gammazza A,Macaluso F,Di Felice V,Cappello F,Barone R

更新日期：2018-11-22 00:00:00

abstract：:Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a, TAC5-c, ...

journal_title：Cells

authors： Patra MC,Achek A,Kim GY,Panneerselvam S,Shin HJ,Baek WY,Lee WH,Sung J,Jeong U,Cho EY,Kim W,Kim E,Suh CH,Choi S

更新日期：2020-07-09 00:00:00

abstract：:In response to inflammatory stimuli, immune cells reconfigure their metabolism and bioenergetics to generate energy and substrates for cell survival and to launch immune effector functions. As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and ...

journal_title：Cells

authors： Meyers AK,Zhu X

更新日期：2020-07-30 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...

journal_title：Cells

authors： Bonafede R,Brandi J,Manfredi M,Scambi I,Schiaffino L,Merigo F,Turano E,Bonetti B,Marengo E,Cecconi D,Mariotti R

更新日期：2019-09-14 00:00:00

abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...

journal_title：Cells

authors： Rinkenbaugh AL,Baldwin AS

更新日期：2016-04-06 00:00:00