Abstract：
:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another different differentiated cell state avoids the disadvantages of fully reprogramming cells to induced pluripotent stem cells (iPSCs) in terms of faster reprogramming of the needed cells. Trans-differentiation also reduces the risk of tumor formation by avoiding the iPSC state. OSKM factors (Oct4, Sox2, Klf4, and cMyc) accompanied by the JAK-STAT pathway inhibition, followed by the introduction of specific differentiation factors, directly reprogrammed mouse embryonic fibroblasts to chondroblasts. Our results showed the absence of intermediate induced pluripotent stem cell formation. The resulting aggregates showed clear hyaline and hypertrophic cartilage. Tumor formation was absent in sub-cutaneous capsules transplanted in SCID mice.
journal_name
Cellsjournal_title
Cellsauthors
Cota P,Helmi SA,Hsu C,Rancourt DEdoi
10.3390/cells9010191subject
Has Abstractpub_date
2020-01-11 00:00:00issue
1issn
2073-4409pii
cells9010191journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract：:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7030020
更新日期：2018-03-10 00:00:00
abstract：:YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic lupus erythematosus and Sjögren's syndrome. Deregulation of YRNAs...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051281
更新日期：2020-05-21 00:00:00
abstract：:The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010030
更新日期：2020-12-27 00:00:00
abstract：:Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its recepto...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8101123
更新日期：2019-09-21 00:00:00
abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080785
更新日期：2019-07-28 00:00:00
abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092069
更新日期：2020-09-10 00:00:00
abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8040359
更新日期：2019-04-17 00:00:00
abstract：:Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of pathology, and a spectrum of experimental models have been developed towa...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9071713
更新日期：2020-07-16 00:00:00
abstract：:The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050426
更新日期：2019-05-08 00:00:00
abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010090
更新日期：2021-01-07 00:00:00
abstract：:There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122581
更新日期：2020-12-02 00:00:00
abstract：:White adipose tissue (WAT) lipolysis contributes to energy balance during fasting. Lipolysis can proceed by the sequential hydrolysis of triglycerides (TGs) by adipose triglyceride lipase (ATGL), then of diacylglycerols (DGs) by hormone-sensitive lipase (HSL). We showed that the combined genetic deficiency of ATGL and...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050395
更新日期：2019-04-29 00:00:00
abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8090954
更新日期：2019-08-22 00:00:00
abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060053
更新日期：2018-06-02 00:00:00
abstract：:One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7080107
更新日期：2018-08-14 00:00:00
abstract：:Skin models with efficient skin barrier function are required for percutaneous absorption studies. The contribution of media supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) to the development of the skin barrier function of in vitro skin models remains incompletely understood. To investigate wheth...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101142
更新日期：2019-09-25 00:00:00
abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010039
更新日期：2019-12-21 00:00:00
abstract：:As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops. However, antibodies and their derivatives remain the gold standard for the design of new therapeutics. In response, clinical-stage therapeutic proteins ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030610
更新日期：2020-03-04 00:00:00
abstract：:The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112475
更新日期：2020-11-13 00:00:00
abstract：:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structura...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092006
更新日期：2020-09-01 00:00:00
abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010079
更新日期：2019-12-28 00:00:00
abstract：:The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102298
更新日期：2020-10-15 00:00:00
abstract：:Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple sclerosis (MS), the most common inflammatory autoimmune disease of the CNS, leads to the destruction of myelin sheaths and the myelin-producing ol...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080825
更新日期：2019-08-03 00:00:00
abstract：:The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101287
更新日期：2019-10-21 00:00:00
abstract：:The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors targeting ALK rearrangements, but resistance inevitably emerges. Some of the mechanisms of resistance are sensitive to novel ALK inhibitors but af...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010168
更新日期：2021-01-15 00:00:00
abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020449
更新日期：2020-02-15 00:00:00
abstract：:Cell extrusion is a striking morphological event found in epithelia and endothelia. It is distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in either apical or basal directions; and loss of mechanochemical homogeneity within monolayers, as cells that are fated to be extrud...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061416
更新日期：2020-06-07 00:00:00
abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040887
更新日期：2020-04-04 00:00:00
abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020367
更新日期：2020-02-05 00:00:00
abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112371
更新日期：2020-10-29 00:00:00
