解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells10020244
更新日期:2021-01-27 00:00:00
abstract::Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10020233
更新日期:2021-01-25 00:00:00
abstract::Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10020215
更新日期:2021-01-22 00:00:00
abstract::HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010192
更新日期:2021-01-19 00:00:00
abstract::CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010181
更新日期:2021-01-18 00:00:00
abstract::Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor cells with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition and stemness potential, and this heterogeneity can hinder their characteriza...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010158
更新日期:2021-01-15 00:00:00
abstract::The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors targeting ALK rearrangements, but resistance inevitably emerges. Some of the mechanisms of resistance are sensitive to novel ALK inhibitors but af...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010168
更新日期:2021-01-15 00:00:00
abstract::β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac fu...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010154
更新日期:2021-01-14 00:00:00
abstract::Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in the excitation/inhibition balance (E/I ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010134
更新日期:2021-01-12 00:00:00
abstract::Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010144
更新日期:2021-01-12 00:00:00
abstract::Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010117
更新日期:2021-01-10 00:00:00
abstract::Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010101
更新日期:2021-01-08 00:00:00
abstract::Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010085
更新日期:2021-01-07 00:00:00
abstract::Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010090
更新日期:2021-01-07 00:00:00
abstract::Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010082
更新日期:2021-01-06 00:00:00
abstract::Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear. Low levels of ROS and enhanced antioxidant defenses are shown to contribute to increasing radioresistance. However, the role of Nrf2-Keap1-Bach1 signaling in the radio...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010083
更新日期:2021-01-06 00:00:00
abstract::Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010075
更新日期:2021-01-05 00:00:00
abstract::Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear functional domains. We performed limited proteolysis followed by ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010068
更新日期:2021-01-04 00:00:00
abstract::In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010063
更新日期:2021-01-03 00:00:00
abstract::Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010056
更新日期:2021-01-01 00:00:00
abstract::Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010048
更新日期:2020-12-31 00:00:00
abstract::Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010050
更新日期:2020-12-31 00:00:00
abstract::Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010052
更新日期:2020-12-31 00:00:00
abstract::The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010030
更新日期:2020-12-27 00:00:00
abstract::Although del Río-Hortega originally reported that leptomeningeal cells are the source of ramified microglia in the developing brain, recent views do not seem to pay much attention to this notion. In this study, in vitro experiments were conducted to determine whether leptomeninges generate ramified microglia. The lept...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010024
更新日期:2020-12-25 00:00:00
abstract::Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and dif...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010025
更新日期:2020-12-25 00:00:00
abstract::Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010016
更新日期:2020-12-24 00:00:00
abstract::Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010009
更新日期:2020-12-22 00:00:00
abstract::Mast cells are long-lived, granular, myeloid-derived leukocytes that have significant protective and repair functions in tissues. Mast cells sense disruptions in the local microenvironment and are first responders to physical, chemical and biological insults. When activated, mast cells release growth factors, protease...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122713
更新日期:2020-12-18 00:00:00
abstract::Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll-/-) exhibit elevated tissue levels of MAGs in association with res...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122705
更新日期:2020-12-17 00:00:00
abstract::In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122689
更新日期:2020-12-15 00:00:00
abstract::Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders are the leading causes of death and disability worldwide. Metabolic diseases cause vascular dysfunction and loss of capillaries termed capillary rarefaction. Interestingly, obesity seems to affect capillary beds in an organ-sp...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122683
更新日期:2020-12-14 00:00:00
abstract::Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122667
更新日期:2020-12-11 00:00:00
abstract::The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclear transport recepto...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122654
更新日期:2020-12-10 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122623
更新日期:2020-12-07 00:00:00
abstract::Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122616
更新日期:2020-12-05 00:00:00
abstract::Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122593
更新日期:2020-12-03 00:00:00
abstract::Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122579
更新日期:2020-12-02 00:00:00
abstract::The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122580
更新日期:2020-12-02 00:00:00
abstract::There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122581
更新日期:2020-12-02 00:00:00