GPCR-Hippo Signaling in Cancer.

abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...

journal_title：Cells

authors： Hu LL,Chang HM,Yi Y,Liu Y,Taylor EL,Zheng LP,Leung PCK

更新日期：2019-11-15 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00

abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...

journal_title：Cells

authors： Bolívar S,Navarro X,Udina E

更新日期：2020-09-20 00:00:00

abstract：:The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive (ER+) breast cancer (BC) patients. The aim of this study was to analyze if the biological aggressiveness, underlined in ER+ BC tumors with higher AR/ER ratio, co...

journal_title：Cells

authors： Rangel N,Rondon-Lagos M,Annaratone L,Aristizábal-Pachon AF,Cassoni P,Sapino A,Castellano I

更新日期：2020-04-24 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:Hepatic fibrosis is the consequence of an unresolved wound healing process in response to chronic liver injury and involves multiple cell types and molecular mechanisms. The hepatic endocannabinoid and apelin systems are two signalling pathways with a substantial role in the liver fibrosis pathophysiology-both are upr...

journal_title：Cells

authors： Melgar-Lesmes P,Perramon M,Jiménez W

更新日期：2019-10-24 00:00:00

abstract：:Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...

journal_title：Cells

authors： Berger S,Gureczny S,Reisinger SN,Horvath O,Pollak DD

更新日期：2019-09-01 00:00:00

abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...

journal_title：Cells

authors： Fischer I,Nickel AC,Qin N,Taban K,Pauck D,Steiger HJ,Kamp M,Muhammad S,Hänggi D,Fritsche E,Remke M,Kahlert UD

更新日期：2020-12-15 00:00:00

abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...

journal_title：Cells

authors： Wang Y,You ZH,Yang S,Li X,Jiang TH,Zhou X

更新日期：2019-02-03 00:00:00

abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...

journal_title：Cells

authors： Edin ML,Lih FB,Hammock BD,Thomson S,Zeldin DC,Bishop-Bailey D

更新日期：2020-04-29 00:00:00

abstract：:Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of pathology, and a spectrum of experimental models have been developed towa...

journal_title：Cells

authors： Montgomery ML,Fuller KK

更新日期：2020-07-16 00:00:00

abstract：:Although del Río-Hortega originally reported that leptomeningeal cells are the source of ramified microglia in the developing brain, recent views do not seem to pay much attention to this notion. In this study, in vitro experiments were conducted to determine whether leptomeninges generate ramified microglia. The lept...

journal_title：Cells

authors： Tanaka J,Takahashi H,Yano H,Nakanishi H

更新日期：2020-12-25 00:00:00

abstract：:Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits ...

journal_title：Cells

authors： Gleue L,Schupp J,Zimmer N,Becker E,Frey H,Tuettenberg A,Helm M

更新日期：2020-09-29 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

journal_title：Cells

authors： Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

更新日期：2020-05-08 00:00:00

abstract：:Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably by annexins (Anx) is critical for membrane repair. We applied me...

journal_title：Cells

authors： Croissant C,Gounou C,Bouvet F,Tan S,Bouter A

更新日期：2020-07-21 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

journal_title：Cells

authors： Rolot M,O'Sullivan TE

更新日期：2020-02-01 00:00:00

abstract：:The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...

journal_title：Cells

authors： Luteijn RD,Praest P,Thiele F,Sadasivam SM,Singethan K,Drijfhout JW,Bach C,de Boer SM,Lebbink RJ,Tao S,Helfer M,Bach NC,Protzer U,Costa AI,Killian JA,Drexler I,Wiertz EJHJ

更新日期：2020-08-29 00:00:00

abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...

journal_title：Cells

authors： Olea-Flores M,Zuñiga-Eulogio M,Tacuba-Saavedra A,Bueno-Salgado M,Sánchez-Carvajal A,Vargas-Santiago Y,Mendoza-Catalán MA,Pérez Salazar E,García-Hernández A,Padilla-Benavides T,Navarro-Tito N

更新日期：2019-09-24 00:00:00

abstract：:Actin remodeling is frequently regulated by antagonistic activities driving protrusion and contraction downstream of Rac and Rho small GTPases, respectively. WAVE regulatory complex (WRC), which primarily operates downstream of Rac, plays pivotal roles in neuronal morphogenesis. Recently, two independent studies descr...

journal_title：Cells

authors： Schaks M,Reinke M,Witke W,Rottner K

更新日期：2020-05-29 00:00:00

abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...

journal_title：Cells

authors： Mahli A,Seitz T,Freese K,Frank J,Weiskirchen R,Abdel-Tawab M,Behnam D,Hellerbrand C

更新日期：2019-04-17 00:00:00

abstract：:During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...

journal_title：Cells

authors： Lorén CE,Dahl CP,Do L,Almaas VM,Geiran OR,Mörner S,Hellman U

更新日期：2019-01-29 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...

journal_title：Cells

authors： Rutkowska E,Kwiecień I,Kulik K,Chełstowska B,Kłos K,Rzepecki P,Chciałowski A

更新日期：2021-01-06 00:00:00

abstract：:The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaini...

journal_title：Cells

authors： Rahman S,Canny MD,Buschmann TA,Latham MP

更新日期：2020-07-13 00:00:00

abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

journal_title：Cells

authors： Fields GB

更新日期：2019-08-27 00:00:00

abstract：:Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...

journal_title：Cells

authors： Gragnani L,Lorini S,Marri S,Zignego AL

更新日期：2020-12-24 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:The nuclear envelope (NE) consists of the inner and outer nuclear membranes (INM and ONM), and the nuclear pore complex (NPC), which penetrates the double membrane. ONM continues with the endoplasmic reticulum (ER). INM and NPC can interact with chromatin to regulate the genetic activities of the chromosome. Studies i...

journal_title：Cells

authors： Hirano Y,Asakawa H,Sakuno T,Haraguchi T,Hiraoka Y

更新日期：2020-08-16 00:00:00

abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

journal_title：Cells

authors： Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

更新日期：2019-12-28 00:00:00

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00