Usefulness of the New Hematological Parameter: Reactive Lymphocytes RE-LYMP with Flow Cytometry Markers of Inflammation in COVID-19.

abstract：:The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...

journal_title：Cells

authors： Sgarbi G,Gorini G,Liuzzi F,Solaini G,Baracca A

更新日期：2018-06-21 00:00:00

abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...

journal_title：Cells

authors： Tasca F,Wang Q,Gonçalves MAFV

更新日期：2020-04-13 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...

journal_title：Cells

authors： Chen X,Egly C,Riley AM,Li W,Tewson P,Hughes TE,Quinn AM,Obukhov AG

更新日期：2014-04-04 00:00:00

abstract：:Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate...

journal_title：Cells

authors： Drechsler Y,Vasconcelos EJR,Griggs LM,Diniz PPPV,Collisson E

更新日期：2020-06-09 00:00:00

abstract：:EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...

journal_title：Cells

authors： Zanetti-Domingues LC,Bonner SE,Martin-Fernandez ML,Huber V

更新日期：2020-11-19 00:00:00

abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...

journal_title：Cells

authors： Kaluzki I,Hailemariam-Jahn T,Doll M,Kaufmann R,Balermpas P,Zöller N,Kippenberger S,Meissner M

更新日期：2019-10-28 00:00:00

abstract：:The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes reportedly share with circular RNAs (circRNAs). Interestingly, some ...

journal_title：Cells

authors： Mfossa ACM,Thekkekara Puthenparampil H,Inalegwu A,Coolkens A,Baatout S,Benotmane MA,Huylebroeck D,Quintens R

更新日期：2019-07-26 00:00:00

abstract：:The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

journal_title：Cells

authors： White S,Lin L,Hu K

更新日期：2020-05-29 00:00:00

abstract：:Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...

journal_title：Cells

authors： Ryskamp DA,Redmon S,Jo AO,Križaj D

更新日期：2014-09-12 00:00:00

abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...

journal_title：Cells

authors： Cappellano G,Raineri D,Rolla R,Giordano M,Puricelli C,Vilardo B,Manfredi M,Cantaluppi V,Sainaghi PP,Castello L,De Vita N,Scotti L,Vaschetto R,Dianzani U,Chiocchetti A

更新日期：2021-01-07 00:00:00

abstract：:CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals. To investigate the function of circ-FoxO3 in mouse myoblast cells' (C2C12) differentiation and proliferation, we used RT-qPCR to detect the expressi...

journal_title：Cells

authors： Li X,Li C,Liu Z,Ni W,Yao R,Xu Y,Quan R,Zhang M,Li H,Liu L,Hu S

更新日期：2019-06-19 00:00:00

abstract：:The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...

journal_title：Cells

authors： Baranov MV,Bianchi F,van den Bogaart G

更新日期：2020-12-27 00:00:00

abstract：:Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation, adhesion, morphology, exocytosis, and gene expression. As a result,...

journal_title：Cells

authors： Beck EM,Parnell E,Cowley A,Porter A,Gillespie J,Robinson J,Robinson L,Pannifer AD,Hamon V,Jones P,Morrison A,McElroy S,Timmerman M,Rutjes H,Mahajan P,Wiejak J,Luchowska-Stańska U,Morgan D,Barker G,Rehmann H,Yarwoo

更新日期：2019-11-12 00:00:00

abstract：:Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...

journal_title：Cells

authors： Romaniello R,Zucca C,Arrigoni F,Bonanni P,Panzeri E,Bassi MT,Borgatti R

更新日期：2019-07-02 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...

journal_title：Cells

authors： Stochaj U,Weber SC

更新日期：2020-02-25 00:00:00

abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...

journal_title：Cells

authors： Ferko M,Andelová N,Szeiffová Bačová B,Jašová M

更新日期：2019-11-17 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...

journal_title：Cells

authors： Edin ML,Lih FB,Hammock BD,Thomson S,Zeldin DC,Bishop-Bailey D

更新日期：2020-04-29 00:00:00

abstract：:Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this home...

journal_title：Cells

authors： Marino Gammazza A,Macaluso F,Di Felice V,Cappello F,Barone R

更新日期：2018-11-22 00:00:00

abstract：:Skin models with efficient skin barrier function are required for percutaneous absorption studies. The contribution of media supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) to the development of the skin barrier function of in vitro skin models remains incompletely understood. To investigate wheth...

journal_title：Cells

authors： Simard M,Julien P,Fradette J,Pouliot R

更新日期：2019-09-25 00:00:00

abstract：:Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on the effect of calcit...

journal_title：Cells

authors： Gkotinakou IM,Kechagia E,Pazaitou-Panayiotou K,Mylonis I,Liakos P,Tsakalof A

更新日期：2020-11-09 00:00:00

abstract：:Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...

journal_title：Cells

authors： Heeke S,Mograbi B,Alix-Panabières C,Hofman P

更新日期：2019-07-13 00:00:00

abstract：:Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12-15 months has remained stagnant, in spite of treatment strategies, making GBMs a tremendous challenge clinically. This is at least in part due to the complex interaction of...

journal_title：Cells

authors： Thompson EG,Sontheimer H

更新日期：2019-10-05 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:The authors wish to make the following corrections to this paper [...]. ...

journal_title：Cells

authors： Nemade H,Acharya A,Chaudhari U,Nembo E,Nguemo F,Riet N,Abken H,Hescheler J,Papadopoulos S,Sachinidis A

更新日期：2020-09-24 00:00:00

abstract：:Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by active calcification of the leaflets of the aortic valve. How innate immune cells are involved in disease pathogenesis is not clear. In this study we investigate the role of the pattern recognition receptor Toll-like receptor 7 (TLR...

journal_title：Cells

authors： Karadimou G,Plunde O,Pawelzik SC,Carracedo M,Eriksson P,Franco-Cereceda A,Paulsson-Berne G,Bäck M

更新日期：2020-07-16 00:00:00

abstract：:Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles. Centrosomes serve as major microtubule- and actin cytoskeleton-organizing centers and are involved in a variety of intracellular pr...

journal_title：Cells

authors： Joukov V,De Nicolo A

更新日期：2019-07-10 00:00:00

abstract：:During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...

journal_title：Cells

authors： Plesner T,van de Donk N,Richardson PG

更新日期：2020-02-06 00:00:00