Abstract：
:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activating signals become dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease. In this review, we summarize studies that support evidence for the ability of ILCs to influence tissue and systemic metabolism, as well as how ILCs can be regulated by environmental changes in systemic host metabolism. We also highlight studies demonstrating how ILC- intrinsic metabolism influences their activation, proliferation, and homeostasis. Finally, this review discusses the challenges and open questions in the rapidly expanding field of ILCs and immunometabolism.
journal_name
Cellsjournal_title
Cellsauthors
Rolot M,O'Sullivan TEdoi
10.3390/cells9020334subject
Has Abstractpub_date
2020-02-01 00:00:00issue
2issn
2073-4409pii
cells9020334journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091040
更新日期：2019-09-06 00:00:00
abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122580
更新日期：2020-12-02 00:00:00
abstract：:There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121605
更新日期：2019-12-11 00:00:00
abstract：:The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV patients live longer. Deposition of beta-amyloid (Aβ), a hallmark of Alzheimer's disease (AD), has been observed in subjects with HIV-associat...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8090968
更新日期：2019-08-24 00:00:00
abstract：:HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080849
更新日期：2019-08-07 00:00:00
abstract：:Parkinson's Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. Th...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8030222
更新日期：2019-03-07 00:00:00
abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092028
更新日期：2020-09-03 00:00:00
abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7120276
更新日期：2018-12-19 00:00:00
abstract：:Microalgae have emerged as a promising platform for production of carbon- and energy- rich molecules, notably starch and oil. Establishing an economically viable algal biotechnology sector requires a holistic understanding of algal photosynthesis, physiology, cell cycle and metabolism. Starch/oil productivity is a com...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8101154
更新日期：2019-09-26 00:00:00
abstract：:Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080808
更新日期：2019-08-01 00:00:00
abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080888
更新日期：2019-08-13 00:00:00
abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060062
更新日期：2018-06-15 00:00:00
abstract：:Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple sclerosis (MS), the most common inflammatory autoimmune disease of the CNS, leads to the destruction of myelin sheaths and the myelin-producing ol...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080825
更新日期：2019-08-03 00:00:00
abstract：:Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081833
更新日期：2020-08-04 00:00:00
abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030701
更新日期：2020-03-12 00:00:00
abstract：:The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010030
更新日期：2020-12-27 00:00:00
abstract：:Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020151
更新日期：2019-02-11 00:00:00
abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8040351
更新日期：2019-04-12 00:00:00
abstract：:Osteoarthritis (OA) is a degenerative and inflammatory joint disorder with cartilage loss. Dental pulp stem cells (DPSCs) can undergo chondrogenic differentiation and secrete growth factors associated with tissue repair and immunomodulation. Leukocyte- and platelet-rich fibrin (L-PRF) emerges in regenerative medicine ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040980
更新日期：2020-04-15 00:00:00
abstract：:Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8090993
更新日期：2019-08-28 00:00:00
abstract：:The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030602
更新日期：2020-03-03 00:00:00
abstract：:The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051296
更新日期：2020-05-22 00:00:00
abstract：:Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune condition in which ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091044
更新日期：2019-09-06 00:00:00
abstract：:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9041043
更新日期：2020-04-22 00:00:00
abstract：:Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111469
更新日期：2019-11-19 00:00:00
abstract：:The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis. We report here on its involvement in cellular reprogramming from fibroblasts to induced pluripotent stem cells, ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060529
更新日期：2019-06-02 00:00:00
abstract：:For years, moderate hypothermia (32 °C) has been proposed as an unorthodox therapy for liver injuries, with proven hepatoprotective potential. Yet, limited mechanistic understanding has largely denied its acceptance over conventional pharmaceuticals for hepatoprotection. Today, facing a high prevalence of acetaminophe...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112354
更新日期：2020-10-26 00:00:00
abstract：:The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated sele...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112416
更新日期：2020-11-04 00:00:00
abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010181
更新日期：2021-01-18 00:00:00
abstract：:Single nucleotide polymorphisms (SNPs) in or near the IL2RA gene, that encodes the interleukin-2 (IL-2) receptor α (CD25), are associated with increased risk of immune-mediated diseases including multiple sclerosis (MS). We investigated how the MS-associated IL2RA SNPs rs2104286 and rs11256593 are associated with CD25...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060634
更新日期：2019-06-25 00:00:00
