bHLH Transcription Factor Math6 Antagonizes TGF-β Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions.

abstract：:Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes and cardiovascular disease, and greatly acceler...

journal_title：Cells

authors： Grajales D,Ferreira V,Valverde ÁM

更新日期：2019-10-29 00:00:00

abstract：:Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate...

journal_title：Cells

authors： Drechsler Y,Vasconcelos EJR,Griggs LM,Diniz PPPV,Collisson E

更新日期：2020-06-09 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs f...

journal_title：Cells

authors： Xi Y,Zhang Y,Zhu S,Luo Y,Xu P,Huang Z

更新日期：2020-02-03 00:00:00

abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...

journal_title：Cells

authors： Palmerini E,Setola E,Grignani G,D'Ambrosio L,Comandone A,Righi A,Longhi A,Cesari M,Paioli A,Hakim R,Pierini M,Marchesi E,Vanel D,Pignochino Y,Donati DM,Picci P,Ferrari S

更新日期：2020-10-31 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are...

journal_title：Cells

authors： Seo Y,Shin TH,Ahn JS,Oh SJ,Shin YY,Yang JW,Park HY,Shin SC,Kwon HK,Kim JM,Sung ES,Park GC,Lee BJ,Kim HS

更新日期：2020-03-06 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are a...

journal_title：Cells

authors： Puentes-Rozo PJ,Acosta-López JE,Cervantes-Henríquez ML,Martínez-Banfi ML,Mejia-Segura E,Sánchez-Rojas M,Anaya-Romero ME,Acosta-Hoyos A,García-Llinás GA,Mastronardi CA,Pineda DA,Castellanos FX,Arcos-Burgos M,Vélez JI

更新日期：2019-08-16 00:00:00

abstract：:Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...

journal_title：Cells

authors： Moon H,Jang HN,Liu Y,Choi N,Oh J,Ha J,Zheng X,Shen H

更新日期：2019-07-10 00:00:00

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...

journal_title：Cells

authors： Bolívar S,Navarro X,Udina E

更新日期：2020-09-20 00:00:00

abstract：:As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...

journal_title：Cells

authors： López-Ruiz BA,Zluhan-Martínez E,Sánchez MP,Álvarez-Buylla ER,Garay-Arroyo A

更新日期：2020-12-01 00:00:00

abstract：:Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that th...

journal_title：Cells

authors： Ruksha K,Mezheyeuski A,Nerovnya A,Bich T,Tur G,Gorgun J,Luduena R,Portyanko A

更新日期：2019-01-07 00:00:00

abstract：:Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...

journal_title：Cells

authors： Lu C,Pang D,Li M,Yuan H,Yu T,Huang P,Li J,Chen X,Jiao H,Xie Z,Ouyang H

更新日期：2019-02-01 00:00:00

abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

journal_title：Cells

authors： Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

更新日期：2020-07-15 00:00:00

abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...

journal_title：Cells

authors： Carotenuto P,Pecoraro A,Palma G,Russo G,Russo A

更新日期：2019-09-16 00:00:00

abstract：:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...

journal_title：Cells

authors： Minciacchi VR,Kumar R,Krause DS

更新日期：2021-01-10 00:00:00

abstract：:The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated sele...

journal_title：Cells

authors： Hiebel C,Stürner E,Hoffmeister M,Tascher G,Schwarz M,Nagel H,Behrends C,Münch C,Behl C

更新日期：2020-11-04 00:00:00

abstract：:: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...

journal_title：Cells

authors： Linck-Paulus L,Hellerbrand C,Bosserhoff AK,Dietrich P

更新日期：2020-01-02 00:00:00

abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...

journal_title：Cells

authors： Papiewska-Pająk I,Krzyżanowski D,Katela M,Rivet R,Michlewska S,Przygodzka P,Kowalska MA,Brézillon S

更新日期：2020-06-30 00:00:00

abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...

journal_title：Cells

authors： Kaluzki I,Hailemariam-Jahn T,Doll M,Kaufmann R,Balermpas P,Zöller N,Kippenberger S,Meissner M

更新日期：2019-10-28 00:00:00

abstract：:The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions thro...

journal_title：Cells

authors： Gundogdu R,Hergovich A

更新日期：2019-06-10 00:00:00

abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...

journal_title：Cells

authors： Guo ZH,Yi HC,You ZH

更新日期：2019-08-09 00:00:00

abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...

journal_title：Cells

authors： Kristiani L,Kim M,Kim Y

更新日期：2020-03-14 00:00:00

abstract：:The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

journal_title：Cells

authors： White S,Lin L,Hu K

更新日期：2020-05-29 00:00:00

abstract：:The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...

journal_title：Cells

authors： Holmberg Olausson K,Nistér M,Lindström MS

更新日期：2012-10-15 00:00:00

abstract：:Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

journal_title：Cells

authors： Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

更新日期：2019-06-30 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

journal_title：Cells

authors： Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

更新日期：2020-05-08 00:00:00

abstract：:: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...

journal_title：Cells

authors： Anel A,Gallego-Lleyda A,de Miguel D,Naval J,Martínez-Lostao L

更新日期：2019-02-12 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...

journal_title：Cells

authors： Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

更新日期：2020-06-18 00:00:00