Abstract：
:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the possibility of investigating the relationships between different molecules from a global perspective. In this article, a molecular association network (MAN) is constructed and comprehensively analyzed by integrating the associations among miRNA, lncRNA, protein, drug, and disease, in which any kind of potential associations can be predicted. More specifically, each node in MAN can be represented as a vector by combining two kinds of information including the attribute of the node itself (e.g., sequences of ncRNAs and proteins, semantics of diseases and molecular fingerprints of drugs) and the behavior of the node in the complex network (associations with other nodes). A random forest classifier is trained to classify and predict new interactions or associations between biomolecules. In the experiment, the proposed method achieved a superb performance with an area under curve (AUC) of 0.9735 under a five-fold cross-validation, which showed that the proposed method could provide new insight for exploration of the molecular mechanisms of disease and valuable clues for disease treatment.
journal_name
Cellsjournal_title
Cellsauthors
Guo ZH,Yi HC,You ZHdoi
10.3390/cells8080866subject
Has Abstractpub_date
2019-08-09 00:00:00issue
8issn
2073-4409pii
cells8080866journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020367
更新日期：2020-02-05 00:00:00
abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells6010006
更新日期：2017-02-10 00:00:00
abstract：:In response to inflammatory stimuli, immune cells reconfigure their metabolism and bioenergetics to generate energy and substrates for cell survival and to launch immune effector functions. As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081808
更新日期：2020-07-30 00:00:00
abstract：:(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121577
更新日期：2019-12-05 00:00:00
abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3041102
更新日期：2014-11-27 00:00:00
abstract：:Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been identified in tunicates, an early chordate. To obtain a detailed insight into the ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010211
更新日期：2020-01-14 00:00:00
abstract：:Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010161
更新日期：2020-01-09 00:00:00
abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121476
更新日期：2019-11-21 00:00:00
abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102237
更新日期：2020-10-04 00:00:00
abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010113
更新日期：2020-01-02 00:00:00
abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020390
更新日期：2020-02-07 00:00:00
abstract：:The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spati...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020274
更新日期：2020-01-22 00:00:00
abstract：:In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated a...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071581
更新日期：2020-06-29 00:00:00
abstract：:Investigating adaptive potential and understanding the relative roles of selection and genetic drift in populations of endangered species are essential in conservation. Major histocompatibility complex (MHC) genes characterized by spectacular polymorphism and fitness association have become valuable adaptive markers. ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8040377
更新日期：2019-04-25 00:00:00
abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020397
更新日期：2020-02-09 00:00:00
abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112389
更新日期：2020-10-31 00:00:00
abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081917
更新日期：2020-08-18 00:00:00
abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10020215
更新日期：2021-01-22 00:00:00
abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020334
更新日期：2020-02-01 00:00:00
abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080785
更新日期：2019-07-28 00:00:00
abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8040351
更新日期：2019-04-12 00:00:00
abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050422
更新日期：2019-05-08 00:00:00
abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051096
更新日期：2020-04-29 00:00:00
abstract：:Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051314
更新日期：2020-05-25 00:00:00
abstract：:In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. Here, we...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051087
更新日期：2020-04-28 00:00:00
abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071602
更新日期：2020-07-02 00:00:00
abstract：:Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020362
更新日期：2020-02-04 00:00:00
abstract：:Trichinella spiralis maintains chronic infections within its host, involving a variety of immunomodulatory properties, the mechanisms of which have not been completely elucidated. In this study, we found that T. spiralis infection induced strong regulatory T cell responses through parasite excretory-secretory (ES) pro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111404
更新日期：2019-11-07 00:00:00
abstract：:Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune condition in which ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091044
更新日期：2019-09-06 00:00:00
abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010009
更新日期：2020-12-22 00:00:00
