BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.


:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically recovered disialyl Lewisa and sialyl 6-sulfo Lewisx glycans, which are preferentially expressed in non-malignant colonic epithelial cells and could serve as ligands for the immunosuppressive molecule Siglec-7. We screened several TLR4 ligands and found that among them BGN is highly expressed in cancers and is involved in the epigenetic silencing of Siglec-7 ligands. Suppression of BGN expression substantially downregulated NF-B activity and the marker H3K27me3 in the promoter regions of the SLC26A2 and ST6GalNAc6 genes, which are involved in the synthesis of those glycans, and restored expression of normal glycans as well as Siglec-7 binding activities. We show that in the presence of TLR4, inflammatory stimuli initiate a positive loop involving NF-B that activates BGN and further enhances TLR4 activity. Present findings indicate a putative mechanism for the promotion of carcinogenesis by loss of immunosuppressive ligands by the BGN/TLR4/ NF-B pathway.






Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R




Has Abstract


2020-02-09 00:00:00












  • A Novel Chromosomal Translocation Identified due to Complex Genetic Instability in iPSC Generated for Choroideremia.

    abstract::Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...


    pub_type: 杂志文章


    authors: Erkilic N,Gatinois V,Torriano S,Bouret P,Sanjurjo-Soriano C,Luca V,Damodar K,Cereso N,Puechberty J,Sanchez-Alcudia R,Hamel CP,Ayuso C,Meunier I,Pellestor F,Kalatzis V

    更新日期:2019-09-11 00:00:00

  • Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability.

    abstract::Skin models with efficient skin barrier function are required for percutaneous absorption studies. The contribution of media supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) to the development of the skin barrier function of in vitro skin models remains incompletely understood. To investigate wheth...


    pub_type: 杂志文章


    authors: Simard M,Julien P,Fradette J,Pouliot R

    更新日期:2019-09-25 00:00:00

  • Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD.

    abstract::Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...


    pub_type: 杂志文章,评审


    authors: Nashine S,Kenney MC

    更新日期:2020-04-29 00:00:00

  • Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition.

    abstract::Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...


    pub_type: 杂志文章


    authors: Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller A

    更新日期:2019-12-15 00:00:00

  • Characterization of Brassica rapa RAP2.4-Related Proteins in Stress Response and as CUL3-Dependent E3 Ligase Substrates.

    abstract::The turnip Brassica rapa has important economic value and represents a good model system to study gene function in crop plants. ERF/AP2 transcription factors are a major group of proteins that are often involved in regulating stress-responses and developmental programs. Some ERF/AP2 proteins are targets of CULLIN3-bas...


    pub_type: 杂志文章


    authors: Mooney S,Al-Saharin R,Choi CM,Tucker K,Beathard C,Hellmann HA

    更新日期:2019-04-10 00:00:00

  • Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses.

    abstract::The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs) of m. diaphragma and m. EDL. Intracellular microelectrode recor...


    pub_type: 杂志文章


    authors: Gaydukov A,Bogacheva P,Tarasova E,Molchanova A,Miteva A,Pravdivceva E,Balezina O

    更新日期:2019-07-22 00:00:00

  • Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells.

    abstract::Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...


    pub_type: 杂志文章


    authors: Celik-Selvi BE,Stütz A,Mayer CE,Salhi J,Siegwart G,Sutterlüty H

    更新日期:2019-08-01 00:00:00

  • Current Status in Testing for Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH).

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries with almost 25% affected adults worldwide. The growing public health burden is getting evident when considering that NAFLD-related liver transplantations are predicted to almost double within the next 20 years. Typic...


    pub_type: 杂志文章,评审


    authors: Drescher HK,Weiskirchen S,Weiskirchen R

    更新日期:2019-08-07 00:00:00

  • Cell-Free microRNAs as Potential Oral Cancer Biomarkers: From Diagnosis to Therapy.

    abstract::Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...


    pub_type: 杂志文章,评审


    authors: Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MM

    更新日期:2019-12-17 00:00:00

  • Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink.

    abstract::Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...


    pub_type: 社论


    authors: Ladokhin AS

    更新日期:2020-09-18 00:00:00

  • The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology.

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    pub_type: 杂志文章,评审


    authors: Laganà M,Schlecht-Louf G,Bachelerie F

    更新日期:2021-01-05 00:00:00

  • CCN2 Mediates S1P-Induced Upregulation of COX2 Expression in Human Granulosa-Lutein Cells.

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    pub_type: 杂志文章


    authors: Hu LL,Chang HM,Yi Y,Liu Y,Taylor EL,Zheng LP,Leung PCK

    更新日期:2019-11-15 00:00:00

  • Fatty Acid Oxidation and Mitochondrial Morphology Changes as Key Modulators of the Affinity for ADP in Rat Heart Mitochondria.

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    pub_type: 杂志文章


    authors: Toleikis A,Trumbeckaite S,Liobikas J,Pauziene N,Kursvietiene L,Kopustinskiene DM

    更新日期:2020-02-01 00:00:00

  • Dissecting Aging and Senescence-Current Concepts and Open Lessons.

    abstract::In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of reduced fitness, risk for disease acquisition, and death. Similarl...


    pub_type: 杂志文章,评审


    authors: Schmeer C,Kretz A,Wengerodt D,Stojiljkovic M,Witte OW

    更新日期:2019-11-15 00:00:00

  • Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.

    abstract::Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...


    pub_type: 杂志文章


    authors: Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

    更新日期:2019-12-28 00:00:00

  • Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids.

    abstract::Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...


    pub_type: 杂志文章


    authors: Marzano M,Bejoy J,Cheerathodi MR,Sun L,York SB,Zhao J,Kanekiyo T,Bu G,Meckes DG Jr,Li Y

    更新日期:2019-08-28 00:00:00

  • Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients.

    abstract::(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...


    pub_type: 杂志文章


    authors: Bonig H,Kuçi Z,Kuçi S,Bakhtiar S,Basu O,Bug G,Dennis M,Greil J,Barta A,Kállay KM,Lang P,Lucchini G,Pol R,Schulz A,Sykora KW,Teichert von Luettichau I,Herter-Sprie G,Ashab Uddin M,Jenkin P,Alsultan A,Buechner J,S

    更新日期:2019-12-05 00:00:00

  • Regulation of MT1-MMP Activity through Its Association with ERMs.

    abstract::Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...


    pub_type: 杂志文章


    authors: Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

    更新日期:2020-02-03 00:00:00

  • HSP70 Multi-Functionality in Cancer.

    abstract::The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...


    pub_type: 杂志文章,评审


    authors: Albakova Z,Armeev GA,Kanevskiy LM,Kovalenko EI,Sapozhnikov AM

    更新日期:2020-03-02 00:00:00

  • A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking.

    abstract::P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...


    pub_type: 杂志文章


    authors: Kadioglu O,Efferth T

    更新日期:2019-10-21 00:00:00

  • IL-6 is not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium Tuberculosis H37rv.

    abstract::Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...


    pub_type: 杂志文章


    authors: Ritter K,Sodenkamp JC,Hölscher A,Behrends J,Hölscher C

    更新日期:2020-12-22 00:00:00

  • Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers.

    abstract::Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic in...


    pub_type: 杂志文章,评审


    authors: Blank M

    更新日期:2020-05-27 00:00:00

  • An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer.

    abstract::During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...


    pub_type: 杂志文章,评审


    authors: Biamonti G,Infantino L,Gaglio D,Amato A

    更新日期:2019-12-21 00:00:00

  • Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis.

    abstract::Alcoholic fatty liver disease (AFLD) is characterized by an abnormal accumulation of lipid droplets (LDs) in the liver. Here, we explore the composition of hepatic LDs in a rat model of AFLD. Five to seven weeks of alcohol consumption led to significant increases in hepatic triglyceride mass, along with increases in L...


    pub_type: 杂志文章


    authors: Listenberger L,Townsend E,Rickertsen C,Hains A,Brown E,Inwards EG,Stoeckman AK,Matis MP,Sampathkumar RS,Osna NA,Kharbanda KK

    更新日期:2018-11-24 00:00:00

  • Regulation of the Extracellular Matrix by Ciliary Machinery.

    abstract::The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...


    pub_type: 杂志文章,评审


    authors: Collins I,Wann AKT

    更新日期:2020-01-23 00:00:00

  • Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story.

    abstract::MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and n...


    pub_type: 杂志文章,评审


    authors: Ala U

    更新日期:2020-06-28 00:00:00

  • Siglecs in Brain Function and Neurological Disorders.

    abstract::Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and have been shown to pla...


    pub_type: 杂志文章,评审


    authors: Siddiqui SS,Matar R,Merheb M,Hodeify R,Vazhappilly CG,Marton J,Shamsuddin SA,Al Zouabi H

    更新日期:2019-09-22 00:00:00

  • MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients.

    abstract::A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...


    pub_type: 杂志文章,评审


    authors: Rogobete AF,Sandesc D,Bedreag OH,Papurica M,Popovici SE,Bratu T,Popoiu CM,Nitu R,Dragomir T,AAbed HIM,Ivan MV

    更新日期:2018-12-13 00:00:00

  • Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.

    abstract::Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...


    pub_type: 杂志文章


    authors: Picca A,Saini SK,Mankowski RT,Kamenov G,Anton SD,Manini TM,Buford TW,Wohlgemuth SE,Xiao R,Calvani R,Coelho-Júnior HJ,Landi F,Bernabei R,Hood DA,Marzetti E,Leeuwenburgh C

    更新日期:2020-12-02 00:00:00

  • Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells.

    abstract::Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....


    pub_type: 杂志文章


    authors: Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

    更新日期:2020-11-30 00:00:00