BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.


:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically recovered disialyl Lewisa and sialyl 6-sulfo Lewisx glycans, which are preferentially expressed in non-malignant colonic epithelial cells and could serve as ligands for the immunosuppressive molecule Siglec-7. We screened several TLR4 ligands and found that among them BGN is highly expressed in cancers and is involved in the epigenetic silencing of Siglec-7 ligands. Suppression of BGN expression substantially downregulated NF-B activity and the marker H3K27me3 in the promoter regions of the SLC26A2 and ST6GalNAc6 genes, which are involved in the synthesis of those glycans, and restored expression of normal glycans as well as Siglec-7 binding activities. We show that in the presence of TLR4, inflammatory stimuli initiate a positive loop involving NF-B that activates BGN and further enhances TLR4 activity. Present findings indicate a putative mechanism for the promotion of carcinogenesis by loss of immunosuppressive ligands by the BGN/TLR4/ NF-B pathway.






Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R




Has Abstract


2020-02-09 00:00:00












  • A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment.

    abstract::Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...


    pub_type: 杂志文章,评审


    authors: Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo E

    更新日期:2020-04-22 00:00:00

  • Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients.

    abstract::(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...


    pub_type: 杂志文章


    authors: Bonig H,Kuçi Z,Kuçi S,Bakhtiar S,Basu O,Bug G,Dennis M,Greil J,Barta A,Kállay KM,Lang P,Lucchini G,Pol R,Schulz A,Sykora KW,Teichert von Luettichau I,Herter-Sprie G,Ashab Uddin M,Jenkin P,Alsultan A,Buechner J,S

    更新日期:2019-12-05 00:00:00

  • A Novel Approach for Detecting Unique Variations among Infectious Bacterial Species in Endocarditic Cardiac Valve Vegetation.

    abstract::Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...


    pub_type: 杂志文章


    authors: Hannachi N,Lepidi H,Fontanini A,Takakura T,Bou-Khalil J,Gouriet F,Habib G,Raoult D,Camoin-Jau L,Baudoin JP

    更新日期:2020-08-13 00:00:00

  • Notch Signaling in Breast Cancer: A Role in Drug Resistance.

    abstract::Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...


    pub_type: 杂志文章,评审


    authors: BeLow M,Osipo C

    更新日期:2020-09-29 00:00:00

  • Noninvasive Diagnosis of NAFLD and NASH.

    abstract::The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...


    pub_type: 杂志文章,评审


    authors: Piazzolla VA,Mangia A

    更新日期:2020-04-17 00:00:00

  • FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells.

    abstract::Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...


    pub_type: 杂志文章


    authors: Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

    更新日期:2020-08-20 00:00:00

  • What Do Microglia Really Do in Healthy Adult Brain?

    abstract::Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been stu...


    pub_type: 杂志文章,评审


    authors: Augusto-Oliveira M,Arrifano GP,Lopes-Araújo A,Santos-Sacramento L,Takeda PY,Anthony DC,Malva JO,Crespo-Lopez ME

    更新日期:2019-10-22 00:00:00

  • Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells.

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    pub_type: 杂志文章


    authors: Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

    更新日期:2019-08-13 00:00:00

  • Zebrafish Avatars towards Personalized Medicine-A Comparative Review between Avatar Models.

    abstract::Cancer frequency and prevalence have been increasing in the past decades, with devastating impacts on patients and their families. Despite the great advances in targeted approaches, there is still a lack of methods to predict individual patient responses, and therefore treatments are tailored according to average resp...


    pub_type: 杂志文章,评审


    authors: Costa B,Estrada MF,Mendes RV,Fior R

    更新日期:2020-01-25 00:00:00

  • MiR-26a-5p as a Reference to Normalize MicroRNA qRT-PCR Levels in Plasma Exosomes of Pediatric Hematological Malignancies.

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    pub_type: 杂志文章


    authors: Damanti CC,Gaffo E,Lovisa F,Garbin A,Di Battista P,Gallingani I,Tosato A,Pillon M,Carraro E,Mascarin M,Elia C,Biffi A,Bortoluzzi S,Mussolin L

    更新日期:2021-01-08 00:00:00

  • The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling.

    abstract::Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...


    pub_type: 杂志文章,评审


    authors: Rodríguez C,Martínez-González J

    更新日期:2019-11-21 00:00:00

  • CRISPR/Cas9-Mediated Hitchhike Expression of Functional shRNAs at the Porcine miR-17-92 Cluster.

    abstract::Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...


    pub_type: 杂志文章


    authors: Lu C,Pang D,Li M,Yuan H,Yu T,Huang P,Li J,Chen X,Jiao H,Xie Z,Ouyang H

    更新日期:2019-02-01 00:00:00

  • The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis.

    abstract::Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. Th...


    pub_type: 杂志文章


    authors: Smith E,Palethorpe HM,Tomita Y,Pei JV,Townsend AR,Price TJ,Young JP,Yool AJ,Hardingham JE

    更新日期:2018-07-21 00:00:00

  • Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells.

    abstract::Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...


    pub_type: 杂志文章


    authors: Gundamaraju R,Vemuri R,Chong WC,Myers S,Norouzi S,Shastri MD,Eri R

    更新日期:2018-10-15 00:00:00

  • CDK12: A Potent Target and Biomarker for Human Cancer Therapy.

    abstract::Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...


    pub_type: 杂志文章,评审


    authors: Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

    更新日期:2020-06-18 00:00:00

  • Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection.

    abstract::An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...


    pub_type: 杂志文章,评审


    authors: Aslam M,Ladilov Y

    更新日期:2020-08-25 00:00:00

  • Onset of Telomere Dysfunction and Fusions in Human Ovarian Carcinoma.

    abstract::Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...


    pub_type: 杂志文章


    authors: Huda N,Xu Y,Bates AM,Rankin DA,Kannan N,Gilley D

    更新日期:2019-05-04 00:00:00

  • Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice.

    abstract::Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...


    pub_type: 杂志文章


    authors: Berger S,Gureczny S,Reisinger SN,Horvath O,Pollak DD

    更新日期:2019-09-01 00:00:00

  • Comparison of Multiscale Imaging Methods for Brain Research.

    abstract::A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...


    pub_type: 杂志文章


    authors: Tröger J,Hoischen C,Perner B,Monajembashi S,Barbotin A,Löschberger A,Eggeling C,Kessels MM,Qualmann B,Hemmerich P

    更新日期:2020-06-01 00:00:00

  • SpermQ⁻A Simple Analysis Software to Comprehensively Study Flagellar Beating and Sperm Steering.

    abstract::Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...


    pub_type: 杂志文章


    authors: Hansen JN,Rassmann S,Jikeli JF,Wachten D

    更新日期:2018-12-26 00:00:00

  • Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors.

    abstract::Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...


    pub_type: 杂志文章


    authors: Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

    更新日期:2020-12-03 00:00:00

  • circRNAs Signature as Potential Diagnostic and Prognostic Biomarker for Diabetes Mellitus and Related Cardiovascular Complications.

    abstract::Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...


    pub_type: 杂志文章,评审


    authors: Zaiou M

    更新日期:2020-03-09 00:00:00

  • Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1.

    abstract::Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation and the scavenging of reactive species...


    pub_type: 杂志文章


    authors: Caruso G,Fresta CG,Musso N,Giambirtone M,Grasso M,Spampinato SF,Merlo S,Drago F,Lazzarino G,Sortino MA,Lunte SM,Caraci F

    更新日期:2019-01-17 00:00:00

  • MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks-A Review.

    abstract:BACKGROUND:Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. METHODS:This research was per...


    pub_type: 杂志文章,评审


    authors: Maués JHDS,Aquino Moreira-Nunes CF,Rodriguez Burbano RM

    更新日期:2019-10-15 00:00:00

  • Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells.

    abstract::Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...


    pub_type: 杂志文章


    authors: Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

    更新日期:2020-09-29 00:00:00

  • TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision.

    abstract::Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...


    pub_type: 杂志文章,评审


    authors: Ryskamp DA,Redmon S,Jo AO,Križaj D

    更新日期:2014-09-12 00:00:00

  • ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis.

    abstract::T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...


    pub_type: 杂志文章


    authors: Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

    更新日期:2019-05-24 00:00:00

  • An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids.

    abstract::Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...


    pub_type: 杂志文章


    authors: Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

    更新日期:2019-05-20 00:00:00

  • Intrinsically Disordered SRC-3/AIB1 Protein Undergoes Homeostatic Nuclear Extrusion by Nuclear Budding While Ectopic Expression Induces Nucleophagy.

    abstract::SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon transcriptional coactivation. Given the amplified expression of SRC-3 in ...


    pub_type: 杂志文章


    authors: Cabrita MA,Renart LI,Lau R,Pratt MAC

    更新日期:2019-10-19 00:00:00

  • On the Host Side of the Hepatitis E Virus Life Cycle.

    abstract::Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...


    pub_type: 杂志文章,评审


    authors: Oechslin N,Moradpour D,Gouttenoire J

    更新日期:2020-05-22 00:00:00