Abstract：
:Investigating adaptive potential and understanding the relative roles of selection and genetic drift in populations of endangered species are essential in conservation. Major histocompatibility complex (MHC) genes characterized by spectacular polymorphism and fitness association have become valuable adaptive markers. Herein we investigate the variation of all MHC class I and II genes across seven populations of an endangered bird, the crested ibis, of which all current individuals are offspring of only two pairs. We inferred seven multilocus haplotypes from linked alleles in the Core Region and revealed structural variation of the class II region that probably evolved through unequal crossing over. Based on the low polymorphism, structural variation, strong linkage, and extensive shared alleles, we applied the MHC haplotypes in population analysis. The genetic variation and population structure at MHC haplotypes are generally concordant with those expected from microsatellites, underlining the predominant role of genetic drift in shaping MHC variation in the bottlenecked populations. Nonetheless, some populations showed elevated differentiation at MHC, probably due to limited gene flow. The seven populations were significantly differentiated into three groups and some groups exhibited genetic monomorphism, which can be attributed to founder effects. We therefore propose various strategies for future conservation and management.
journal_name
Cellsjournal_title
Cellsauthors
Lan H,Zhou T,Wan QH,Fang SGdoi
10.3390/cells8040377subject
Has Abstractpub_date
2019-04-25 00:00:00issue
4issn
2073-4409pii
cells8040377journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:Although del Río-Hortega originally reported that leptomeningeal cells are the source of ramified microglia in the developing brain, recent views do not seem to pay much attention to this notion. In this study, in vitro experiments were conducted to determine whether leptomeninges generate ramified microglia. The lept...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010024
更新日期：2020-12-25 00:00:00
abstract：:Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122579
更新日期：2020-12-02 00:00:00
abstract：:Nitric oxide (NO) is an important mediator of inflammation response and the production of NO has been linked to a variety of diseases, including tumors, inflammation and central nervous system diseases. In macrophages, a high level of NO is generated by iNOS during inflammatory responses triggered by cytokines or path...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101255
更新日期：2019-10-15 00:00:00
abstract：:Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010025
更新日期：2019-01-07 00:00:00
abstract：:Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122554
更新日期：2020-11-28 00:00:00
abstract：:Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102204
更新日期：2020-09-29 00:00:00
abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010113
更新日期：2020-01-02 00:00:00
abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040887
更新日期：2020-04-04 00:00:00
abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081917
更新日期：2020-08-18 00:00:00
abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091040
更新日期：2019-09-06 00:00:00
abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111434
更新日期：2019-11-13 00:00:00
abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020379
更新日期：2020-02-06 00:00:00
abstract：:The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 and mTORC2. mTORC1 coordinates cell growth and metabolism in response to environ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091075
更新日期：2019-09-12 00:00:00
abstract：:Trichinella spiralis maintains chronic infections within its host, involving a variety of immunomodulatory properties, the mechanisms of which have not been completely elucidated. In this study, we found that T. spiralis infection induced strong regulatory T cell responses through parasite excretory-secretory (ES) pro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111404
更新日期：2019-11-07 00:00:00
abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020337
更新日期：2020-02-01 00:00:00
abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110218
更新日期：2018-11-20 00:00:00
abstract：:Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen synthesis. The eff...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071667
更新日期：2020-07-10 00:00:00
abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020271
更新日期：2020-01-22 00:00:00
abstract：:In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010063
更新日期：2021-01-03 00:00:00
abstract：:Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092142
更新日期：2020-09-22 00:00:00
abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040984
更新日期：2020-04-16 00:00:00
abstract：:The zygote is defined as a diploid cell resulting from the fusion of two haploid gametes. Union of haploid male and female pronuclei in many animals occurs through rearrangements of the microtubule cytoskeleton into a radial array of microtubules known as the sperm aster. The sperm aster nucleates from paternally-deri...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020505
更新日期：2020-02-23 00:00:00
abstract：:The authors wish to make the following erratum to this paper [1].[...]. ...
journal_title：Cells
pub_type： 杂志文章,已发布勘误
doi：10.3390/cells5030036
更新日期：2016-09-20 00:00:00
abstract：:Cell extrusion is a striking morphological event found in epithelia and endothelia. It is distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in either apical or basal directions; and loss of mechanochemical homogeneity within monolayers, as cells that are fated to be extrud...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061416
更新日期：2020-06-07 00:00:00
abstract：:Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050415
更新日期：2019-05-05 00:00:00
abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030701
更新日期：2020-03-12 00:00:00
abstract：:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060059
更新日期：2018-06-14 00:00:00
abstract：:Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020113
更新日期：2019-02-01 00:00:00
abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080888
更新日期：2019-08-13 00:00:00
abstract：:Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivator...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122540
更新日期：2020-11-25 00:00:00
