Abstract：
:Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 × 10-4), rs2282794-FGF1 (A allele; p = 1.33 × 10-2), rs2122642-ADGRL3 (C allele, p = 3.5 × 10-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.
journal_name
Cellsjournal_title
Cellsauthors
Puentes-Rozo PJ,Acosta-López JE,Cervantes-Henríquez ML,Martínez-Banfi ML,Mejia-Segura E,Sánchez-Rojas M,Anaya-Romero ME,Acosta-Hoyos A,García-Llinás GA,Mastronardi CA,Pineda DA,Castellanos FX,Arcos-Burgos M,Vélez JIdoi
10.3390/cells8080907subject
Has Abstractpub_date
2019-08-16 00:00:00issue
8issn
2073-4409pii
cells8080907journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8040351
更新日期：2019-04-12 00:00:00
abstract：:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010075
更新日期：2021-01-05 00:00:00
abstract：:Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091105
更新日期：2019-09-18 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs f...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020352
更新日期：2020-02-03 00:00:00
abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060604
更新日期：2019-06-17 00:00:00
abstract：:BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030574
更新日期：2020-02-28 00:00:00
abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050496
更新日期：2019-05-23 00:00:00
abstract：:Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030645
更新日期：2020-03-06 00:00:00
abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112371
更新日期：2020-10-29 00:00:00
abstract：:Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051102
更新日期：2020-04-29 00:00:00
abstract：:In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there has been a great deal of progress in the implementation of EpCAM-based CTC detection technol...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081836
更新日期：2020-08-05 00:00:00
abstract：:Coronary artery disease is the most common form of cardiovascular diseases, resulting in the loss of cardiomyocytes (CM) at the site of ischemic injury. To compensate for the loss of CMs, cardiac fibroblasts quickly respond to injury and initiate cardiac remodeling in an injured heart. In the remodeling process, cardi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070679
更新日期：2019-07-04 00:00:00
abstract：:Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070669
更新日期：2019-07-02 00:00:00
abstract：:Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080875
更新日期：2019-08-11 00:00:00
abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081914
更新日期：2020-08-18 00:00:00
abstract：:The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclear transport recepto...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122654
更新日期：2020-12-10 00:00:00
abstract：:Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051211
更新日期：2020-05-13 00:00:00
abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050481
更新日期：2019-05-20 00:00:00
abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122558
更新日期：2020-11-29 00:00:00
abstract：:Cell extrusion is a striking morphological event found in epithelia and endothelia. It is distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in either apical or basal directions; and loss of mechanochemical homogeneity within monolayers, as cells that are fated to be extrud...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061416
更新日期：2020-06-07 00:00:00
abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080812
更新日期：2019-08-02 00:00:00
abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030745
更新日期：2020-03-18 00:00:00
abstract：:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070687
更新日期：2019-07-07 00:00:00
abstract：OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071689
更新日期：2020-07-14 00:00:00
abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112430
更新日期：2020-11-06 00:00:00
abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092047
更新日期：2020-09-08 00:00:00
abstract：:Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen synthesis. The eff...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071667
更新日期：2020-07-10 00:00:00
abstract：:Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8030229
更新日期：2019-03-11 00:00:00
abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010072
更新日期：2019-12-27 00:00:00
abstract：:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040929
更新日期：2020-04-10 00:00:00
