Abstract：
:: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expression of immune checkpoint molecules such as CTLA-4 and PD-1, or activation-induced cell death (AICD). In addition, activated T cells release membrane microvesicles called exosomes during these regulatory processes. In this review, we revise the role of exosome secretion in the different pathways of immune regulation described to date and its importance in the prevention or development of autoimmune disease. The expression of membrane-bound death ligands on the surface of exosomes during AICD or the more recently described transfer of miRNA or even DNA inside T-cell exosomes is a molecular mechanism that will be analyzed.
journal_name
Cellsjournal_title
Cellsauthors
Anel A,Gallego-Lleyda A,de Miguel D,Naval J,Martínez-Lostao Ldoi
10.3390/cells8020154subject
Has Abstractpub_date
2019-02-12 00:00:00issue
2issn
2073-4409pii
cells8020154journal_volume
8pub_type
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