Human Tonsil-Derived Mesenchymal Stromal Cells Maintain Proliferating and ROS-Regulatory Properties via Stanniocalcin-1.

Abstract:

:Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are not yet precisely elucidated. We investigated the role of stanniocalcin-1 (STC1), an anti-oxidative hormone, in the functions of TMSCs. We found that STC1 was highly expressed in TMSC compared with MSCs from bone marrow or adipose tissue. The proliferation, senescence and differentiation of TMSCs were assessed after the inhibition of STC1 expression. STC1 inhibition resulted in a significant decrease in the proliferation of TMSCs and did not affect the differentiation potential. To reveal the anti-oxidative ability of STC1 in TMSCs themselves or against other cell types, the generation of mitochondrial reactive oxygen species (ROS) in TMSC or ROS-mediated production of interleukin (IL)-1β from macrophage-like cells were detected. Interestingly, the basal level of ROS generation in TMSCs was significantly elevated after STC1 inhibition. Moreover, down-regulation of STC1 impaired the inhibitory effect of TMSCs on IL-1β production in macrophages. Taken together, these findings indicate that STC1 is highly expressed in TMSCs and plays a critical role in proliferating and ROS-regulatory abilities.

journal_name

Cells

journal_title

Cells

authors

Seo Y,Shin TH,Ahn JS,Oh SJ,Shin YY,Yang JW,Park HY,Shin SC,Kwon HK,Kim JM,Sung ES,Park GC,Lee BJ,Kim HS

doi

10.3390/cells9030636

subject

Has Abstract

pub_date

2020-03-06 00:00:00

issue

3

issn

2073-4409

pii

cells9030636

journal_volume

9

pub_type

杂志文章

相关文献

Cells文献大全
  • Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers.

    abstract::Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic in...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9061340

    authors: Blank M

    更新日期:2020-05-27 00:00:00

  • Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk.

    abstract::Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells7100162

    authors: Aguilera MO,Delgui LR,Romano PS,Colombo MI

    更新日期:2018-10-10 00:00:00

  • Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells.

    abstract::Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9081914

    authors: Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

    更新日期:2020-08-18 00:00:00

  • The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases.

    abstract::Autoimmune rheumatic diseases (ARDs), affecting ~1-1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020462

    authors: Bank I

    更新日期:2020-02-18 00:00:00

  • Cell-Free microRNAs as Potential Oral Cancer Biomarkers: From Diagnosis to Therapy.

    abstract::Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8121653

    authors: Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MM

    更新日期:2019-12-17 00:00:00

  • Nuclear Progestin Receptor Phosphorylation by Cdk9 Is Required for the Expression of Mmp15, a Protease Indispensable for Ovulation in Medaka.

    abstract::Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8030215

    authors: Ogiwara K,Takahashi T

    更新日期:2019-03-04 00:00:00

  • Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis.

    abstract::Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020393

    authors: Saccenti L,Hagiwara A,Andica C,Yokoyama K,Fujita S,Kato S,Maekawa T,Kamagata K,Le Berre A,Hori M,Wada A,Tateishi U,Hattori N,Aoki S

    更新日期:2020-02-08 00:00:00

  • Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.

    abstract::Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020359

    authors: Amir M,Khan P,Queen A,Dohare R,Alajmi MF,Hussain A,Islam A,Ahmad F,Hassan I

    更新日期:2020-02-04 00:00:00

  • Structure and Function of Human Matrix Metalloproteinases.

    abstract::The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9051076

    authors: Laronha H,Caldeira J

    更新日期:2020-04-26 00:00:00

  • Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma.

    abstract::: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010114

    authors: Linck-Paulus L,Hellerbrand C,Bosserhoff AK,Dietrich P

    更新日期:2020-01-02 00:00:00

  • FTH1 Pseudogenes in Cancer and Cell Metabolism.

    abstract::Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9122554

    authors: Di Sanzo M,Quaresima B,Biamonte F,Palmieri C,Faniello MC

    更新日期:2020-11-28 00:00:00

  • Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.

    abstract::Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9010079

    authors: Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

    更新日期:2019-12-28 00:00:00

  • p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease.

    abstract::Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8040351

    authors: Héraud C,Pinault M,Lagrée V,Moreau V

    更新日期:2019-04-12 00:00:00

  • On the Host Side of the Hepatitis E Virus Life Cycle.

    abstract::Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9051294

    authors: Oechslin N,Moradpour D,Gouttenoire J

    更新日期:2020-05-22 00:00:00

  • In Silico Evaluation of Putative S100B Interacting Proteins in Healthy and IBD Gut Microbiota.

    abstract::The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9071697

    authors: Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

    更新日期:2020-07-15 00:00:00

  • microRNAs and Cardiac Cell Fate.

    abstract::The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their ro...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells3030802

    authors: Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini A

    更新日期:2014-08-05 00:00:00

  • Role of Wnt Signaling During In-Vitro Bovine Blastocyst Development and Maturation in Synergism with PPARδ Signaling.

    abstract::Wnt/β-catenin signaling plays vital role in the regulation of cellular proliferation, migration, stem cells cell renewal and genetic stability. This pathway is crucial during the early developmental process; however, the distinct role of Wnt/β-catenin signaling during pre-implantation period of bovine embryonic develo...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9040923

    authors: Sidrat T,Khan AA,Idrees M,Joo MD,Xu L,Lee KL,Kong IK

    更新日期:2020-04-09 00:00:00

  • Microbial Alterations and Risk Factors of Breast Cancer: Connections and Mechanistic Insights.

    abstract::Breast cancer-related mortality remains high worldwide, despite tremendous advances in diagnostics and therapeutics; hence, the quest for better strategies for disease management, as well as the identification of modifiable risk factors, continues. With recent leaps in genomic technologies, microbiota have emerged as ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9051091

    authors: Parida S,Sharma D

    更新日期:2020-04-28 00:00:00

  • Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.

    abstract::Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9030740

    authors: Hong CT,Chen KY,Wang W,Chiu JY,Wu D,Chao TY,Hu CJ,Chau KD,Bamodu OA

    更新日期:2020-03-17 00:00:00

  • Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular Vesicles.

    abstract::EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9112505

    authors: Zanetti-Domingues LC,Bonner SE,Martin-Fernandez ML,Huber V

    更新日期:2020-11-19 00:00:00

  • Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.

    abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9030704

    authors: Chu YH,Su CW,Hsieh YS,Chen PN,Lin CW,Yang SF

    更新日期:2020-03-13 00:00:00

  • Living with Yourself: Innate Lymphoid Cell Immunometabolism.

    abstract::Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020334

    authors: Rolot M,O'Sullivan TE

    更新日期:2020-02-01 00:00:00

  • Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8050488

    authors: Reddy PH,Oliver DM

    更新日期:2019-05-22 00:00:00

  • Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids.

    abstract::While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9030537

    authors: Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

    更新日期:2020-02-26 00:00:00

  • Nanomodulation of Macrophages in Multiple Sclerosis.

    abstract::Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8060543

    authors: Nally FK,De Santi C,McCoy CE

    更新日期:2019-06-05 00:00:00

  • The ubiquitin-conjugating system: multiple roles in viral replication and infection.

    abstract::Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells3020386

    authors: Calistri A,Munegato D,Carli I,Parolin C,Palù G

    更新日期:2014-05-06 00:00:00

  • Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future.

    abstract::Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells10010117

    authors: Minciacchi VR,Kumar R,Krause DS

    更新日期:2021-01-10 00:00:00

  • Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition.

    abstract::Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8121644

    authors: Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller A

    更新日期:2019-12-15 00:00:00

  • IL-6 is not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium Tuberculosis H37rv.

    abstract::Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells10010009

    authors: Ritter K,Sodenkamp JC,Hölscher A,Behrends J,Hölscher C

    更新日期:2020-12-22 00:00:00

  • Hypoxia and IF₁ Expression Promote ROS Decrease in Cancer Cells.

    abstract::The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells7070064

    authors: Sgarbi G,Gorini G,Liuzzi F,Solaini G,Baracca A

    更新日期:2018-06-21 00:00:00