Abstract:
:The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated selective macroautophagy. To adapt cellular homeostasis to stress, BAG3 modulates and functions in various cellular processes and signaling pathways. Noteworthy, dysfunction and deregulation of BAG3 and its pathway are pathophysiologically linked to myopathies, cancer, and neurodegenerative disorders. Here, we report a BAG3 proteomic signature under proteostasis stress. To elucidate the dynamic and multifunctional action of BAG3 in response to stress, we established BAG3 interactomes under basal and proteostasis stress conditions by employing affinity purification combined with quantitative mass spectrometry. In addition to the identification of novel potential BAG3 interactors, we defined proteins whose interaction with BAG3 was altered upon stress. By functional annotation and protein-protein interaction enrichment analysis of the identified potential BAG3 interactors, we confirmed the multifunctionality of BAG3 and highlighted its crucial role in diverse cellular signaling pathways and processes, ensuring cellular proteostasis and cell viability. These include protein folding and degradation, gene expression, cytoskeleton dynamics (including cell cycle and transport), as well as granulostasis, in particular.
journal_name
Cellsjournal_title
Cellsauthors
Hiebel C,Stürner E,Hoffmeister M,Tascher G,Schwarz M,Nagel H,Behrends C,Münch C,Behl Cdoi
10.3390/cells9112416subject
Has Abstractpub_date
2020-11-04 00:00:00issue
11issn
2073-4409pii
cells9112416journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract::More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061475
更新日期:2020-06-16 00:00:00
abstract::An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9091962
更新日期:2020-08-25 00:00:00
abstract::Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020449
更新日期:2020-02-15 00:00:00
abstract::(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121577
更新日期:2019-12-05 00:00:00
abstract::Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102185
更新日期:2020-09-28 00:00:00
abstract::Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112473
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. METHODS:This research was per...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101256
更新日期:2019-10-15 00:00:00
abstract::Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells3020247
更新日期:2014-04-04 00:00:00
abstract::The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101155
更新日期:2019-09-27 00:00:00
abstract::The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aqu...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091094
更新日期:2019-09-17 00:00:00
abstract::: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020154
更新日期:2019-02-12 00:00:00
abstract::Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030524
更新日期:2020-02-25 00:00:00
abstract::During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons. The sEPSC is mediated by transient receptor potential canonical 3 (TR...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7080090
更新日期:2018-07-29 00:00:00
abstract::Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112399
更新日期:2020-11-02 00:00:00
abstract::Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070660
更新日期:2019-06-30 00:00:00
abstract::A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7120271
更新日期:2018-12-13 00:00:00
abstract::Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expres...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020144
更新日期:2019-02-11 00:00:00
abstract::All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in the proteasome, mediated by three types of ubiquitin enzymes: E1...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102219
更新日期:2020-10-01 00:00:00
abstract::Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050415
更新日期:2019-05-05 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7050038
更新日期:2018-05-08 00:00:00
abstract::The finding that transcription occurs at chromosome ends has opened new fields of study on the roles of telomeric transcripts in chromosome end maintenance and genome stability. Indeed, the ends of chromosomes are required to be protected from activation of DNA damage response and DNA repair pathways. Chromosome end p...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8030246
更新日期:2019-03-15 00:00:00
abstract::Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030740
更新日期:2020-03-17 00:00:00
abstract::Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWA...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010246
更新日期:2020-01-18 00:00:00
abstract::The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091097
更新日期:2019-09-17 00:00:00
abstract::Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010039
更新日期:2019-12-21 00:00:00
abstract::Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8010008
更新日期:2018-12-22 00:00:00
abstract::Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8010054
更新日期:2019-01-15 00:00:00
abstract::Increasing evidence suggests that metabolic alterations may be etiologically linked to neurodegenerative disorders such as Parkinson's disease (PD) and in particular empathizes the possibility of targeting mitochondrial dysfunctions to improve PD progression. Under different pathological conditions (i.e., cardiac and ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9092037
更新日期:2020-09-06 00:00:00
abstract::Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010052
更新日期:2020-12-31 00:00:00
abstract:BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122558
更新日期:2020-11-29 00:00:00