Abstract：
:Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWAS studies to generate biological interpretation of the existing population genetic data, including both molecular (creation and analysis of knockout animals, exploration of the transcriptional effects of common variants in human brain cells) and computational (fine-mapping of causal variability, gene set enrichment analysis, partitioned heritability analysis) methods. The results of the crucial studies, in which these approaches were used to uncover the molecular and neurobiological basis of the disease, are also reported.
journal_name
Cellsjournal_title
Cellsauthors
Golov AK,Kondratyev NV,Kostyuk GP,Golimbet AVEdoi
10.3390/cells9010246subject
Has Abstractpub_date
2020-01-18 00:00:00issue
1issn
2073-4409pii
cells9010246journal_volume
9pub_type
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