Abstract：
:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or xenogenic tendon extracellular matrix (ECM) have recently started to attract interest. This ECM combines the advantages of its intrinsic mechanical competence with that of providing tenogenic stimuli for immigrating cells mediated, for example, by the growth factors and other mediators entrapped within the natural ECM. A major restriction for their therapeutic application is the mainly cell-associated immunogenicity of xenogenic or allogenic tissues and, in the case of allogenic tissues, also the risk of disease transmission. A survey of approaches for tendon reconstruction using cell-free tendon ECM is presented here, whereby the problems associated with the decellularization procedures, the success of various recellularization strategies, and the applicable cell types will be thoroughly discussed. Encouraging in vivo results using cell-free ECM, as, for instance, in rabbit models, have already been reported. However, in comparison to native tendon, cells remain mostly inhomogeneously distributed in the reseeded ECM and do not align. Hence, future work should focus on the optimization of tendon ECM decellularization and recolonization strategies to restore tendon functionality.
journal_name
Cellsjournal_title
Cellsauthors
Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan Adoi
10.3390/cells1041010subject
Has Abstractpub_date
2012-11-05 00:00:00pages
1010-28issue
4issn
2073-4409pii
cells1041010journal_volume
1pub_type
杂志文章相关文献
Cells文献大全abstract：:In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9091941
更新日期：2020-08-21 00:00:00
abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010082
更新日期：2021-01-06 00:00:00
abstract：:S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated. The aim of this study is to investigate the possible role of a small molecule abl...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030748
更新日期：2020-03-18 00:00:00
abstract：:Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles. Centrosomes serve as major microtubule- and actin cytoskeleton-organizing centers and are involved in a variety of intracellular pr...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070701
更新日期：2019-07-10 00:00:00
abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010048
更新日期：2020-12-31 00:00:00
abstract：:The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050426
更新日期：2019-05-08 00:00:00
abstract：:Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dy...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112348
更新日期：2020-10-23 00:00:00
abstract：:Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010101
更新日期：2021-01-08 00:00:00
abstract：:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120271
更新日期：2018-12-13 00:00:00
abstract：:Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100178
更新日期：2018-10-22 00:00:00
abstract：:Fatty acids are the main respiratory substrates important for cardiac function, and their oxidation is altered during various chronic disorders. We investigated the mechanism of fatty acid-oxidation-induced changes and their relations with mitochondrial morphology and ADP/ATP carrier conformation on the kinetics of th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020340
更新日期：2020-02-01 00:00:00
abstract：:The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis. We report here on its involvement in cellular reprogramming from fibroblasts to induced pluripotent stem cells, ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060529
更新日期：2019-06-02 00:00:00
abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092074
更新日期：2020-09-11 00:00:00
abstract：:BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030574
更新日期：2020-02-28 00:00:00
abstract：:The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8101155
更新日期：2019-09-27 00:00:00
abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091087
更新日期：2019-09-14 00:00:00
abstract：:Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) represent important ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells2020266
更新日期：2013-04-26 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030636
更新日期：2020-03-06 00:00:00
abstract：:Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030599
更新日期：2020-03-03 00:00:00
abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8030215
更新日期：2019-03-04 00:00:00
abstract：:There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122581
更新日期：2020-12-02 00:00:00
abstract：:A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-associated glucocort...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051068
更新日期：2020-04-25 00:00:00
abstract：:All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in the proteasome, mediated by three types of ubiquitin enzymes: E1...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102219
更新日期：2020-10-01 00:00:00
abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110218
更新日期：2018-11-20 00:00:00
abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030713
更新日期：2020-03-13 00:00:00
abstract：:The zygote is defined as a diploid cell resulting from the fusion of two haploid gametes. Union of haploid male and female pronuclei in many animals occurs through rearrangements of the microtubule cytoskeleton into a radial array of microtubules known as the sperm aster. The sperm aster nucleates from paternally-deri...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020505
更新日期：2020-02-23 00:00:00
abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051096
更新日期：2020-04-29 00:00:00
abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030745
更新日期：2020-03-18 00:00:00
abstract：:Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020117
更新日期：2019-02-02 00:00:00
abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080937
更新日期：2019-08-20 00:00:00
