At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.

abstract：:DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprin...

journal_title：Cells

authors： Borchiellini M,Ummarino S,Di Ruscio A

更新日期：2019-10-12 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Autophagy is an intracellular catabolic system that delivers cytoplasmic constituents and organelles in the vacuole. This degradative process is mediated by a group of proteins coded by autophagy-related (ATG) genes that are widely conserved from yeasts to plants and mammals. Homologs of ATG genes have been also ident...

journal_title：Cells

authors： Pérez-Pérez ME,Couso I,Heredia-Martínez LG,Crespo JL

更新日期：2017-10-22 00:00:00

abstract：:We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S. typhimurium A1-R was demonstrated in vivo and vitro using several malignant cell lines including melanoma, sarcoma, glioma, breast, pancreat...

journal_title：Cells

authors： Murakami T,Hiroshima Y,Miyake K,Kiyuna T,Endo I,Zhao M,Hoffman RM

更新日期：2019-06-16 00:00:00

abstract：:Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...

journal_title：Cells

authors： Sandrini L,Ieraci A,Amadio P,Zarà M,Mitro N,Lee FS,Tremoli E,Barbieri SS

更新日期：2019-08-11 00:00:00

abstract：:In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatric diseases, where study subjects are almost exclusively children...

journal_title：Cells

authors： Faresjö M

更新日期：2012-05-29 00:00:00

abstract：:Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...

journal_title：Cells

authors： Richter D,Bartig D,Muhlack S,Hartelt E,Scherbaum R,Katsanos AH,Müller T,Jost W,Ebersbach G,Gold R,Krogias C,Tönges L

更新日期：2019-02-11 00:00:00

abstract：:To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA signature in HNSCC, both strands of the miR-99a-duplex (miR-99a-5p: the guide strand, and miR-99a-3p: the passen...

journal_title：Cells

authors： Okada R,Koshizuka K,Yamada Y,Moriya S,Kikkawa N,Kinoshita T,Hanazawa T,Seki N

更新日期：2019-11-28 00:00:00

abstract：:While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signali...

journal_title：Cells

authors： Ziller N,Kotolloshi R,Esmaeili M,Liebisch M,Mrowka R,Baniahmad A,Liehr T,Wolf G,Loeffler I

更新日期：2020-10-03 00:00:00

abstract：:Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...

journal_title：Cells

authors： Gundamaraju R,Vemuri R,Chong WC,Myers S,Norouzi S,Shastri MD,Eri R

更新日期：2018-10-15 00:00:00

abstract：:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...

journal_title：Cells

authors： Tang BL

更新日期：2018-06-14 00:00:00

abstract：:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...

journal_title：Cells

authors： Aguilera MO,Delgui LR,Romano PS,Colombo MI

更新日期：2018-10-10 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...

journal_title：Cells

authors： Gowkielewicz M,Lipka A,Majewska M,Piotrowska A,Szadurska-Noga M,Nowakowski JJ,Wiszpolska M,Dzięgiel P,Wasniewski T,Majewski MK,Jozwik M

更新日期：2020-10-17 00:00:00

abstract：:Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48-72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the li...

journal_title：Cells

authors： Estrella JFGL,Immanuel J,Wiley V,Simmons D

更新日期：2020-10-15 00:00:00

abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...

journal_title：Cells

authors： Diez-Fraile A,Ceulaer J,Derpoorter C,Spaas C,Backer T,Lamoral P,Abeloos J,Lammens T

更新日期：2020-12-31 00:00:00

abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...

journal_title：Cells

authors： Edin ML,Lih FB,Hammock BD,Thomson S,Zeldin DC,Bishop-Bailey D

更新日期：2020-04-29 00:00:00

abstract：:Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...

journal_title：Cells

authors： Zaiou M

更新日期：2020-06-16 00:00:00

abstract：:The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development. IGF-...

journal_title：Cells

authors： Blyth AJ,Kirk NS,Forbes BE

更新日期：2020-10-12 00:00:00

abstract：:In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...

journal_title：Cells

authors： Tournier BB,Tsartsalis S,Ceyzériat K,Garibotto V,Millet P

更新日期：2020-08-21 00:00:00

abstract：:TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia. Here we investigated the role of TonEBP in acute kidney injury (AKI) using a line of TonEBP haplo-deficient mice s...

journal_title：Cells

authors： Yoo EJ,Lim SW,Kang HJ,Park H,Yoon S,Nam D,Sanada S,Kwon MJ,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2019-10-20 00:00:00

abstract：:Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The mechanisms of the stimulus-secretion coupling involve the participation of the key enzymes that metabolize the nutrients, and numerous ion ...

journal_title：Cells

authors： Islam MS

更新日期：2020-03-11 00:00:00

abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...

journal_title：Cells

authors： Farrag M,Leipzig ND

更新日期：2018-10-17 00:00:00

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:Nitric oxide (NO) is an important mediator of inflammation response and the production of NO has been linked to a variety of diseases, including tumors, inflammation and central nervous system diseases. In macrophages, a high level of NO is generated by iNOS during inflammatory responses triggered by cytokines or path...

journal_title：Cells

authors： Wang J,Wu MY,Su H,Lu J,Chen X,Tan J,Lu JH

更新日期：2019-10-15 00:00:00

abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...

journal_title：Cells

authors： Kim YH,Cho KA,Lee HJ,Park M,Shin SJ,Park JW,Woo SY,Ryu KH

更新日期：2020-01-15 00:00:00

abstract：:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have histor...

journal_title：Cells

authors： Thornton SM,Samararatne VD,Skeate JG,Buser C,Lühen KP,Taylor JR,Da Silva DM,Kast WM

更新日期：2020-04-15 00:00:00

abstract：:Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes ...

journal_title：Cells

authors： Happé C,Kurakula K,Sun XQ,da Silva Goncalves Bos D,Rol N,Guignabert C,Tu L,Schalij I,Wiesmeijer KC,Tura-Ceide O,Vonk Noordegraaf A,de Man FS,Bogaard HJ,Goumans MJ

更新日期：2020-06-08 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell signaling, both in healthy and pathologic conditions. Being nano-size...

journal_title：Cells

authors： Ailuno G,Baldassari S,Lai F,Florio T,Caviglioli G

更新日期：2020-12-01 00:00:00