MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients.

Abstract:

:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.

journal_name

Cells

journal_title

Cells

authors

Rogobete AF,Sandesc D,Bedreag OH,Papurica M,Popovici SE,Bratu T,Popoiu CM,Nitu R,Dragomir T,AAbed HIM,Ivan MV

doi

10.3390/cells7120271

subject

Has Abstract

pub_date

2018-12-13 00:00:00

issue

12

issn

2073-4409

pii

cells7120271

journal_volume

7

pub_type

杂志文章,评审

相关文献

Cells文献大全
  • Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway.

    abstract::Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8020117

    authors: Kalailingam P,Tan HB,Pan JY,Tan SH,Thanabalu T

    更新日期:2019-02-02 00:00:00

  • CDK12: A Potent Target and Biomarker for Human Cancer Therapy.

    abstract::Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9061483

    authors: Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

    更新日期:2020-06-18 00:00:00

  • Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response.

    abstract::Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9051314

    authors: Chu KB,Lee HA,Kang HJ,Moon EK,Quan FS

    更新日期:2020-05-25 00:00:00

  • Epilepsy in Tubulinopathy: Personal Series and Literature Review.

    abstract::Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8070669

    authors: Romaniello R,Zucca C,Arrigoni F,Bonanni P,Panzeri E,Bassi MT,Borgatti R

    更新日期:2019-07-02 00:00:00

  • Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium.

    abstract::Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling p...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010118

    authors: Tschaikner P,Enzler F,Torres-Quesada O,Aanstad P,Stefan E

    更新日期:2020-01-03 00:00:00

  • Differential Expression and Localization of Branchial AQP1 and AQP3 in Japanese Medaka (Oryzias latipes).

    abstract::Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8050422

    authors: Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

    更新日期:2019-05-08 00:00:00

  • Rab GTPases: Switching to Human Diseases.

    abstract::Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8080909

    authors: Guadagno NA,Progida C

    更新日期:2019-08-16 00:00:00

  • Purine DNA Lesions at Different Oxygen Concentration in DNA Repair-Impaired Human Cells (EUE-siXPA).

    abstract::Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role of XP-A in NER pathways has been well studied while discrepancies associated with ROS levels and the role of radical speci...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8111377

    authors: Krokidis MG,Parlanti E,D'Errico M,Pascucci B,Pino A,Alimonti A,Pietraforte D,Masi A,Ferreri C,Chatgilialoglu C

    更新日期:2019-11-01 00:00:00

  • Regulation of the Extracellular Matrix by Ciliary Machinery.

    abstract::The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020278

    authors: Collins I,Wann AKT

    更新日期:2020-01-23 00:00:00

  • Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells.

    abstract::Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8121523

    authors: Barrault L,Gide J,Qing T,Lesueur L,Tost J,Denis JA,Cailleret M,Aubry L,Peschanski M,Martinat C,Baghdoyan S

    更新日期:2019-11-26 00:00:00

  • PML Bodies in Mitosis.

    abstract::Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8080893

    authors: Lång A,Lång E,Bøe SO

    更新日期:2019-08-14 00:00:00

  • HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1.

    abstract::We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9102237

    authors: Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

    更新日期:2020-10-04 00:00:00

  • The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.

    abstract::Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030784

    authors: Tebbe L,Kakakhel M,Makia MS,Al-Ubaidi MR,Naash MI

    更新日期:2020-03-24 00:00:00

  • Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome.

    abstract::We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9092015

    authors: Tovar I,Guerrero R,López-Peñalver JJ,Expósito J,Ruiz de Almodóvar JM

    更新日期:2020-09-02 00:00:00

  • Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression.

    abstract::Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells10010056

    authors: Armitage JD,Newnes HV,McDonnell A,Bosco A,Waithman J

    更新日期:2021-01-01 00:00:00

  • Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery.

    abstract::Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8121627

    authors: Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

    更新日期:2019-12-12 00:00:00

  • Neuron-Astrocyte Interactions in Parkinson's Disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9122623

    authors: Miyazaki I,Asanuma M

    更新日期:2020-12-07 00:00:00

  • Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8050488

    authors: Reddy PH,Oliver DM

    更新日期:2019-05-22 00:00:00

  • NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration.

    abstract::Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9040808

    authors: Romeo-Guitart D,Casas C

    更新日期:2020-03-27 00:00:00

  • Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.

    abstract::The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9092020

    authors: Kim JY,Barua S,Huang MY,Park J,Yenari MA,Lee JE

    更新日期:2020-09-02 00:00:00

  • Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.

    abstract::Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8050415

    authors: Sabir N,Hussain T,Liao Y,Wang J,Song Y,Shahid M,Cheng G,Mangi MH,Yao J,Yang L,Zhao D,Zhou X

    更新日期:2019-05-05 00:00:00

  • Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future.

    abstract::Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells10010117

    authors: Minciacchi VR,Kumar R,Krause DS

    更新日期:2021-01-10 00:00:00

  • A Novel Approach for Detecting Unique Variations among Infectious Bacterial Species in Endocarditic Cardiac Valve Vegetation.

    abstract::Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9081899

    authors: Hannachi N,Lepidi H,Fontanini A,Takakura T,Bou-Khalil J,Gouriet F,Habib G,Raoult D,Camoin-Jau L,Baudoin JP

    更新日期:2020-08-13 00:00:00

  • Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.

    abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9030704

    authors: Chu YH,Su CW,Hsieh YS,Chen PN,Lin CW,Yang SF

    更新日期:2020-03-13 00:00:00

  • Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling.

    abstract::Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8020158

    authors: Berg G,Barchuk M,Miksztowicz V

    更新日期:2019-02-14 00:00:00

  • PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development.

    abstract::This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8101272

    authors: Idrees M,Xu L,Song SH,Joo MD,Lee KL,Muhammad T,El Sheikh M,Sidrat T,Kong IK

    更新日期:2019-10-18 00:00:00

  • Noninvasive Diagnosis of NAFLD and NASH.

    abstract::The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9041005

    authors: Piazzolla VA,Mangia A

    更新日期:2020-04-17 00:00:00

  • Host-HIV-1 Interactome: A Quest for Novel Therapeutic Intervention.

    abstract::The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8101155

    authors: Shukla E,Chauhan R

    更新日期:2019-09-27 00:00:00

  • Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels.

    abstract::Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells7110218

    authors: Mederos Y Schnitzler M,Gudermann T,Storch U

    更新日期:2018-11-20 00:00:00

  • An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer.

    abstract::During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010034

    authors: Biamonti G,Infantino L,Gaglio D,Amato A

    更新日期:2019-12-21 00:00:00