Abstract:
:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.
journal_name
Cellsjournal_title
Cellsauthors
Rogobete AF,Sandesc D,Bedreag OH,Papurica M,Popovici SE,Bratu T,Popoiu CM,Nitu R,Dragomir T,AAbed HIM,Ivan MVdoi
10.3390/cells7120271subject
Has Abstractpub_date
2018-12-13 00:00:00issue
12issn
2073-4409pii
cells7120271journal_volume
7pub_type
杂志文章,评审相关文献
Cells文献大全abstract::Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020117
更新日期:2019-02-02 00:00:00
abstract::Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061483
更新日期:2020-06-18 00:00:00
abstract::Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051314
更新日期:2020-05-25 00:00:00
abstract::Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070669
更新日期:2019-07-02 00:00:00
abstract::Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling p...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010118
更新日期:2020-01-03 00:00:00
abstract::Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050422
更新日期:2019-05-08 00:00:00
abstract::Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080909
更新日期:2019-08-16 00:00:00
abstract::Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role of XP-A in NER pathways has been well studied while discrepancies associated with ROS levels and the role of radical speci...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111377
更新日期:2019-11-01 00:00:00
abstract::The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020278
更新日期:2020-01-23 00:00:00
abstract::Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121523
更新日期:2019-11-26 00:00:00
abstract::Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080893
更新日期:2019-08-14 00:00:00
abstract::We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102237
更新日期:2020-10-04 00:00:00
abstract::Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030784
更新日期:2020-03-24 00:00:00
abstract::We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092015
更新日期:2020-09-02 00:00:00
abstract::Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010056
更新日期:2021-01-01 00:00:00
abstract::Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121627
更新日期:2019-12-12 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122623
更新日期:2020-12-07 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050488
更新日期:2019-05-22 00:00:00
abstract::Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040808
更新日期:2020-03-27 00:00:00
abstract::The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092020
更新日期:2020-09-02 00:00:00
abstract::Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050415
更新日期:2019-05-05 00:00:00
abstract::Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010117
更新日期:2021-01-10 00:00:00
abstract::Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081899
更新日期:2020-08-13 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030704
更新日期:2020-03-13 00:00:00
abstract::Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020158
更新日期:2019-02-14 00:00:00
abstract::This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101272
更新日期:2019-10-18 00:00:00
abstract::The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9041005
更新日期:2020-04-17 00:00:00
abstract::The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101155
更新日期:2019-09-27 00:00:00
abstract::Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7110218
更新日期:2018-11-20 00:00:00
abstract::During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010034
更新日期:2019-12-21 00:00:00