Abstract：
:Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, although with low sequence conservation. Trypanosomatids such as Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for serious tropical diseases in humans. The parasites are transmitted by insects and, consequently, have a complicated life cycle during which they undergo dramatic morphological and metabolic transformations to adapt to the different environments. Autophagy plays a major role during these transformations. Since inhibition of autophagy affects the transformation, survival and/or virulence of the parasites, the ATGs offer promise for development of drugs against tropical diseases. Furthermore, various trypanocidal drugs have been shown to trigger autophagy-like processes in the parasites. It is inferred that autophagy is used by the parasites in an-not always successful-attempt to cope with the stress caused by the toxic compounds.
journal_name
Cellsjournal_title
Cellsauthors
Brennand A,Rico E,Michels PAdoi
10.3390/cells1030346subject
Has Abstractpub_date
2012-07-27 00:00:00pages
346-71issue
3issn
2073-4409pii
cells1030346journal_volume
1pub_type
杂志文章相关文献
Cells文献大全abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091097
更新日期：2019-09-17 00:00:00
abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050481
更新日期：2019-05-20 00:00:00
abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010113
更新日期：2020-01-02 00:00:00
abstract：:Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020151
更新日期：2019-02-11 00:00:00
abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050422
更新日期：2019-05-08 00:00:00
abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081914
更新日期：2020-08-18 00:00:00
abstract：:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050414
更新日期：2019-05-04 00:00:00
abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091927
更新日期：2020-08-20 00:00:00
abstract：:Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10020233
更新日期：2021-01-25 00:00:00
abstract：:Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050449
更新日期：2019-05-13 00:00:00
abstract：:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060059
更新日期：2018-06-14 00:00:00
abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050507
更新日期：2019-05-26 00:00:00
abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080866
更新日期：2019-08-09 00:00:00
abstract：:During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020378
更新日期：2020-02-06 00:00:00
abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112389
更新日期：2020-10-31 00:00:00
abstract：:There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122581
更新日期：2020-12-02 00:00:00
abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081811
更新日期：2020-07-30 00:00:00
abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010221
更新日期：2020-01-15 00:00:00
abstract：:Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8070696
更新日期：2019-07-10 00:00:00
abstract：:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structura...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092006
更新日期：2020-09-01 00:00:00
abstract：:Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells3030914
更新日期：2014-09-12 00:00:00
abstract：:DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprin...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8101243
更新日期：2019-10-12 00:00:00
abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121598
更新日期：2019-12-09 00:00:00
abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080830
更新日期：2019-08-05 00:00:00
abstract：:Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081831
更新日期：2020-08-04 00:00:00
abstract：:Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121523
更新日期：2019-11-26 00:00:00
abstract：:Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112525
更新日期：2020-11-23 00:00:00
abstract：:This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101272
更新日期：2019-10-18 00:00:00
abstract：:The aggregation of proteins compromises cell fitness, either because it titrates functional proteins into non-productive inclusions or because it results in the formation of toxic assemblies. Accordingly, computational proteome-wide analyses suggest that prevention of aggregation upon misfolding plays a key role in se...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080856
更新日期：2019-08-08 00:00:00
abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111329
更新日期：2019-10-28 00:00:00
