Conditioned Medium from Human Tonsil-Derived Mesenchymal Stem Cells Enhances Bone Marrow Engraftment via Endothelial Cell Restoration by Pleiotrophin.

abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...

journal_title：Cells

authors： Zhang L,Chen X,Yin J

更新日期：2019-09-06 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...

journal_title：Cells

authors： Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

更新日期：2020-06-18 00:00:00

abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...

journal_title：Cells

authors： Nascimento RA,Possomato-Vieira JS,Bonacio GF,Rizzi E,Dias-Junior CA

更新日期：2019-11-07 00:00:00

abstract：:Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...

journal_title：Cells

authors： Shi CS,Kuo KL,Chen MS,Chow PM,Liu SH,Chang YW,Lin WC,Liao SM,Hsu CH,Hsu FS,Chang HC,Huang KH

更新日期：2019-11-19 00:00:00

abstract：:Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of pathology, and a spectrum of experimental models have been developed towa...

journal_title：Cells

authors： Montgomery ML,Fuller KK

更新日期：2020-07-16 00:00:00

abstract：:Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...

journal_title：Cells

authors： Konno T,Melo EP,Chambers JE,Avezov E

更新日期：2021-01-25 00:00:00

abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...

journal_title：Cells

authors： Cappellano G,Raineri D,Rolla R,Giordano M,Puricelli C,Vilardo B,Manfredi M,Cantaluppi V,Sainaghi PP,Castello L,De Vita N,Scotti L,Vaschetto R,Dianzani U,Chiocchetti A

更新日期：2021-01-07 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...

journal_title：Cells

authors： Kögel D,Linder B,Brunschweiger A,Chines S,Behl C

更新日期：2020-02-28 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00

abstract：:Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...

journal_title：Cells

authors： Holopainen M,Impola U,Lehenkari P,Laitinen S,Kerkelä E

更新日期：2020-09-22 00:00:00

abstract：:Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSC...

journal_title：Cells

authors： Di Baldassarre A,Cimetta E,Bollini S,Gaggi G,Ghinassi B

更新日期：2018-05-25 00:00:00

abstract：:Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....

journal_title：Cells

authors： Moretti E,Favero G,Rodella LF,Rezzani R

更新日期：2020-03-03 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00

abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

journal_title：Cells

authors： Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of t...

journal_title：Cells

authors： Al-Rashed F,Alghaith A,Azim R,AlMekhled D,Thomas R,Sindhu S,Ahmad R

更新日期：2020-05-11 00:00:00

abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

journal_title：Cells

authors： Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

更新日期：2020-02-04 00:00:00

abstract：:Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been stu...

journal_title：Cells

authors： Augusto-Oliveira M,Arrifano GP,Lopes-Araújo A,Santos-Sacramento L,Takeda PY,Anthony DC,Malva JO,Crespo-Lopez ME

更新日期：2019-10-22 00:00:00

abstract：:The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo...

journal_title：Cells

authors： Luo J,Yu FX

更新日期：2019-05-08 00:00:00

abstract：:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structura...

journal_title：Cells

authors： Mikhaylova M,Rentsch J,Ewers H

更新日期：2020-09-01 00:00:00

abstract：:Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed for regenerative medicine, cardiovascular research, and pharmacological studies. However, the differentiation of adult MSC into a cardiac lineage is challenging compared to ...

journal_title：Cells

authors： Mueller P,Wolfien M,Ekat K,Lang CI,Koczan D,Wolkenhauer O,Hahn O,Peters K,Lang H,David R,Lemcke H

更新日期：2020-02-22 00:00:00

abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...

journal_title：Cells

authors： Diez-Fraile A,Ceulaer J,Derpoorter C,Spaas C,Backer T,Lamoral P,Abeloos J,Lammens T

更新日期：2020-12-31 00:00:00

abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...

journal_title：Cells

authors： Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi C

更新日期：2019-12-01 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority. Still, our understanding of how disseminated cancer cells survive in the foreign metastatic environment, and eventually cause met...

journal_title：Cells

authors： Montagner M,Dupont S

更新日期：2020-01-19 00:00:00

abstract：:Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...

journal_title：Cells

authors： Guadagno NA,Progida C

更新日期：2019-08-16 00:00:00

abstract：:In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as ...

journal_title：Cells

authors： Poovathumkadavil P,Jagla K

更新日期：2020-06-25 00:00:00

abstract：:Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...

journal_title：Cells

authors： Sulima SO,Kampen KR,De Keersmaecker K

更新日期：2019-03-11 00:00:00

abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...

journal_title：Cells

authors： Farrag M,Leipzig ND

更新日期：2018-10-17 00:00:00