Abstract:
:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, and clinical characteristics. As it occurs less frequently than advanced-stage EOC, its molecular features have not been thoroughly investigated. In this study, using in silico approaches and gene expression data, on a multicentric cohort composed of 208 snap-frozen tumor biopsies, we explored the subtype-specific molecular alterations that regulate tumor aggressiveness in stage I EOC. We found that single genes rather than pathways are responsible for histotype specificities and that a cAMP-PKA-CREB1 signaling axis seems to play a central role in histotype differentiation. Moreover, our results indicate that immune response seems to be, at least in part, involved in histotype differences, as a higher immune-reactive behavior of serous and mucinous samples was observed with respect to other histotypes.
journal_name
Cellsjournal_title
Cellsauthors
Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi Cdoi
10.3390/cells8121554subject
Has Abstractpub_date
2019-12-01 00:00:00issue
12issn
2073-4409pii
cells8121554journal_volume
8pub_type
杂志文章,多中心研究相关文献
Cells文献大全abstract::Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061503
更新日期:2020-06-20 00:00:00
abstract::Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by active calcification of the leaflets of the aortic valve. How innate immune cells are involved in disease pathogenesis is not clear. In this study we investigate the role of the pattern recognition receptor Toll-like receptor 7 (TLR...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071710
更新日期:2020-07-16 00:00:00
abstract:OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071689
更新日期:2020-07-14 00:00:00
abstract::L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091039
更新日期:2019-09-05 00:00:00
abstract::Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020334
更新日期:2020-02-01 00:00:00
abstract::Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061483
更新日期:2020-06-18 00:00:00
abstract::Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular exosomes containing molecules, that can be transferred to recipient cells to induce pathological processes and significant modifications, as metastasis, increase of pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080777
更新日期:2019-07-25 00:00:00
abstract::White adipose tissue (WAT) lipolysis contributes to energy balance during fasting. Lipolysis can proceed by the sequential hydrolysis of triglycerides (TGs) by adipose triglyceride lipase (ATGL), then of diacylglycerols (DGs) by hormone-sensitive lipase (HSL). We showed that the combined genetic deficiency of ATGL and...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050395
更新日期:2019-04-29 00:00:00
abstract::Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030701
更新日期:2020-03-12 00:00:00
abstract::Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050389
更新日期:2019-04-28 00:00:00
abstract::More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061475
更新日期:2020-06-16 00:00:00
abstract::The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050404
更新日期:2019-05-01 00:00:00
abstract::Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Escherichia coli (E. coli) has long been a popular model organism for basic biological research. In this paper, weighted gene co-expression network analysis (WGCNA) algorithm was ap...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7030019
更新日期:2018-03-08 00:00:00
abstract::Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060601
更新日期:2019-06-17 00:00:00
abstract::CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111445
更新日期:2019-11-15 00:00:00
abstract::Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092131
更新日期:2020-09-20 00:00:00
abstract::Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010221
更新日期:2020-01-15 00:00:00
abstract::Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080808
更新日期:2019-08-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051211
更新日期:2020-05-13 00:00:00
abstract::Autoimmune rheumatic diseases (ARDs), affecting ~1-1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020462
更新日期:2020-02-18 00:00:00
abstract::The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080920
更新日期:2019-08-17 00:00:00
abstract::Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells8050413
更新日期:2019-05-04 00:00:00
abstract::Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091018
更新日期:2019-09-01 00:00:00
abstract::The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051076
更新日期:2020-04-26 00:00:00
abstract::The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102298
更新日期:2020-10-15 00:00:00
abstract::Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080836
更新日期:2019-08-05 00:00:00
abstract::Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081833
更新日期:2020-08-04 00:00:00
abstract::Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8060543
更新日期:2019-06-05 00:00:00
abstract::Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030535
更新日期:2020-02-25 00:00:00
abstract::Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic strategies has been constant. In this context, some cellular (enh...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071612
更新日期:2020-07-03 00:00:00