Abstract:
:Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed.
journal_name
Cellsjournal_title
Cellsauthors
Lyu J,Yang EJ,Shim JSdoi
10.3390/cells8050389subject
Has Abstractpub_date
2019-04-28 00:00:00issue
5issn
2073-4409pii
cells8050389journal_volume
8pub_type
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