Abstract：
:Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may result in sarcopenia. Therefore, sarcopenia may act as a strong predictor of frailty, disability, and mortality associated with HF. Currently, standard treatments for slowing muscle loss in patients with HF are not available. Therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in HF as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in HF and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance.
journal_name
Cellsjournal_title
Cellsauthors
Cho J,Choi Y,Sajgalik P,No MH,Lee SH,Kim S,Heo JW,Cho EJ,Chang E,Kang JH,Kwak HB,Park DHdoi
10.3390/cells9102284subject
Has Abstractpub_date
2020-10-13 00:00:00issue
10issn
2073-4409pii
cells9102284journal_volume
9pub_type
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