Correction: Nemade, H.; et al. Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells. Cells 2020, 9, 554.

abstract：BACKGROUND:Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. METHODS:This research was per...

journal_title：Cells

authors： Maués JHDS,Aquino Moreira-Nunes CF,Rodriguez Burbano RM

更新日期：2019-10-15 00:00:00

abstract：:Trichinella spiralis maintains chronic infections within its host, involving a variety of immunomodulatory properties, the mechanisms of which have not been completely elucidated. In this study, we found that T. spiralis infection induced strong regulatory T cell responses through parasite excretory-secretory (ES) pro...

journal_title：Cells

authors： Sun XM,Guo K,Hao CY,Zhan B,Huang JJ,Zhu X

更新日期：2019-11-07 00:00:00

abstract：:Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...

journal_title：Cells

authors： Hsu YH,Chuang HC,Lee YH,Lin YF,Chiu YJ,Wang YL,Wu MS,Chiu HW

更新日期：2019-06-17 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...

journal_title：Cells

authors： Laganà M,Schlecht-Louf G,Bachelerie F

更新日期：2021-01-05 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs f...

journal_title：Cells

authors： Xi Y,Zhang Y,Zhu S,Luo Y,Xu P,Huang Z

更新日期：2020-02-03 00:00:00

abstract：:Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...

journal_title：Cells

authors： Di Sanzo M,Quaresima B,Biamonte F,Palmieri C,Faniello MC

更新日期：2020-11-28 00:00:00

abstract：:Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...

journal_title：Cells

authors： Nouwen LV,Everts B

更新日期：2020-01-09 00:00:00

abstract：:Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation and the scavenging of reactive species...

journal_title：Cells

authors： Caruso G,Fresta CG,Musso N,Giambirtone M,Grasso M,Spampinato SF,Merlo S,Drago F,Lazzarino G,Sortino MA,Lunte SM,Caraci F

更新日期：2019-01-17 00:00:00

abstract：:S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated. The aim of this study is to investigate the possible role of a small molecule abl...

journal_title：Cells

authors： Di Sante G,Amadio S,Sampaolese B,Clementi ME,Valentini M,Volonté C,Casalbore P,Ria F,Michetti F

更新日期：2020-03-18 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...

journal_title：Cells

authors： Aguilera MO,Delgui LR,Romano PS,Colombo MI

更新日期：2018-10-10 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a, TAC5-c, ...

journal_title：Cells

authors： Patra MC,Achek A,Kim GY,Panneerselvam S,Shin HJ,Baek WY,Lee WH,Sung J,Jeong U,Cho EY,Kim W,Kim E,Suh CH,Choi S

更新日期：2020-07-09 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell typ...

journal_title：Cells

authors： Santos J,Hubert T,Milthorpe BK

更新日期：2020-03-04 00:00:00

abstract：:A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-associated glucocort...

journal_title：Cells

authors： Hisaoka-Nakashima K,Azuma H,Ishikawa F,Nakamura Y,Wang D,Liu K,Wake H,Nishibori M,Nakata Y,Morioka N

更新日期：2020-04-25 00:00:00

abstract：:Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) represent important ...

journal_title：Cells

authors： Wali JA,Masters SL,Thomas HE

更新日期：2013-04-26 00:00:00

abstract：:The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut glioma, limiting the discovery of new effective chemotherapeutic agen...

journal_title：Cells

authors： Dao Trong P,Jungwirth G,Yu T,Pusch S,Unterberg A,Herold-Mende C,Warta R

更新日期：2020-06-03 00:00:00

abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...

journal_title：Cells

authors： Mederos Y Schnitzler M,Gudermann T,Storch U

更新日期：2018-11-20 00:00:00

abstract：:Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and functioning. In humans, mutations in the gene encoding Hspb8 ...

journal_title：Cells

authors： Dubińska-Magiera M,Niedbalska-Tarnowska J,Migocka-Patrzałek M,Posyniak E,Daczewska M

更新日期：2020-06-26 00:00:00

abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...

journal_title：Cells

authors： Fantini V,Bordoni M,Scocozza F,Conti M,Scarian E,Carelli S,Di Giulio AM,Marconi S,Pansarasa O,Auricchio F,Cereda C

更新日期：2019-08-05 00:00:00

abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...

journal_title：Cells

authors： Umair M,Alfadhel M

更新日期：2019-12-09 00:00:00

abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...

journal_title：Cells

authors： Schwarz-Cruz Y Celis A,Ceballos-Cancino G,Vazquez-Santillan K,Espinosa M,Zampedri C,Bahena I,Ruiz V,Maldonado V,Melendez-Zajgla J

更新日期：2020-03-13 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...

journal_title：Cells

authors： Lee HS,Vancamelbeke M,Verstockt S,Wilms T,Verstockt B,Sabino J,Ferrante M,Vermeire S,Cleynen I

更新日期：2020-07-28 00:00:00

abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...

journal_title：Cells

authors： Nascimento RA,Possomato-Vieira JS,Bonacio GF,Rizzi E,Dias-Junior CA

更新日期：2019-11-07 00:00:00

abstract：:Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell's ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial ...

journal_title：Cells

authors： Zhou Z,Austin GL,Young LEA,Johnson LA,Sun R

更新日期：2018-11-23 00:00:00

abstract：:Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role of XP-A in NER pathways has been well studied while discrepancies associated with ROS levels and the role of radical speci...

journal_title：Cells

authors： Krokidis MG,Parlanti E,D'Errico M,Pascucci B,Pino A,Alimonti A,Pietraforte D,Masi A,Ferreri C,Chatgilialoglu C

更新日期：2019-11-01 00:00:00