Abstract：
:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.
journal_name
Cellsjournal_title
Cellsauthors
Laganà M,Schlecht-Louf G,Bachelerie Fdoi
10.3390/cells10010075subject
Has Abstractpub_date
2021-01-05 00:00:00issue
1issn
2073-4409pii
cells10010075journal_volume
10pub_type
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