Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats.

abstract：:Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...

journal_title：Cells

authors： Sharko AC,Lim CU,McDermott MSJ,Hennes C,Philavong KP,Aiken T,Tatarskiy VV,Roninson IB,Broude EV

更新日期：2021-01-12 00:00:00

abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...

journal_title：Cells

authors： Bécot A,Pardossi-Piquard R,Bourgeois A,Duplan E,Xiao Q,Diwan A,Lee JM,Lauritzen I,Checler F

更新日期：2020-05-12 00:00:00

abstract：:Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis. We previously observed that dose levels of SFN are crucial in determining life or death of l...

journal_title：Cells

authors： Chhunchha B,Kubo E,Singh DP

更新日期：2019-09-27 00:00:00

abstract：:Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...

journal_title：Cells

authors： Tan Q,Shi S,Liang J,Zhang X,Cao D,Wang Z

更新日期：2020-03-06 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:Chronic hyperglycemia has been associated with an increased prevalence of pathological conditions including cardiovascular disease, cancer, or various disorders of the immune system. In some cases, these associations may be traced back to a common underlying cause, but more often, hyperglycemia and the disturbance in ...

journal_title：Cells

authors： Nagy T,Fisi V,Frank D,Kátai E,Nagy Z,Miseta A

更新日期：2019-08-28 00:00:00

abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...

journal_title：Cells

authors： Chu J,Lu M,Pfeifer CG,Alt V,Docheva D

更新日期：2020-09-08 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where...

journal_title：Cells

authors： Xian J,Owusu Obeng E,Ratti S,Rusciano I,Marvi MV,Fazio A,De Stefano A,Mongiorgi S,Cappellini A,Ramazzotti G,Manzoli L,Cocco L,Follo MY

更新日期：2020-03-12 00:00:00

abstract：OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...

journal_title：Cells

authors： Ichise Y,Saegusa J,Tanaka-Natsui S,Naka I,Hayashi S,Kuroda R,Morinobu A

更新日期：2020-07-14 00:00:00

abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...

journal_title：Cells

authors： Chiaradonna F,Ricciardiello F,Palorini R

更新日期：2018-06-02 00:00:00

abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...

journal_title：Cells

authors： Guo ZH,Yi HC,You ZH

更新日期：2019-08-09 00:00:00

abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...

journal_title：Cells

authors： Okamoto T,Kawamoto E,Usuda H,Tanaka T,Nikai T,Asanuma K,Suzuki K,Shimaoka M,Wada K

更新日期：2020-07-30 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...

journal_title：Cells

authors： Mahli A,Seitz T,Freese K,Frank J,Weiskirchen R,Abdel-Tawab M,Behnam D,Hellerbrand C

更新日期：2019-04-17 00:00:00

abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...

journal_title：Cells

authors： Romeo-Guitart D,Casas C

更新日期：2020-03-27 00:00:00

abstract：:Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...

journal_title：Cells

authors： Messner M,Ghadge SK,Maurer T,Graber M,Staggl S,Christine Maier S,Pölzl G,Zaruba MM

更新日期：2020-08-28 00:00:00

abstract：:Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...

journal_title：Cells

authors： Richter D,Bartig D,Muhlack S,Hartelt E,Scherbaum R,Katsanos AH,Müller T,Jost W,Ebersbach G,Gold R,Krogias C,Tönges L

更新日期：2019-02-11 00:00:00

abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...

journal_title：Cells

authors： Cappellano G,Raineri D,Rolla R,Giordano M,Puricelli C,Vilardo B,Manfredi M,Cantaluppi V,Sainaghi PP,Castello L,De Vita N,Scotti L,Vaschetto R,Dianzani U,Chiocchetti A

更新日期：2021-01-07 00:00:00

abstract：:Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly underst...

journal_title：Cells

authors： Daignan-Fornier B,Pinson B

更新日期：2019-01-17 00:00:00

abstract：:In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...

journal_title：Cells

authors： Felix L,Ziemens D,Seifert G,Rose CR

更新日期：2019-12-31 00:00:00

abstract：:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have histor...

journal_title：Cells

authors： Thornton SM,Samararatne VD,Skeate JG,Buser C,Lühen KP,Taylor JR,Da Silva DM,Kast WM

更新日期：2020-04-15 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:In 2011, I was invited to serve as the Editor-In-Chief for Cells, which back then was a "new kid on the block" among open access (OA) journals.[...]. ...

journal_title：Cells

authors： Kalyuzhny AE

更新日期：2017-11-01 00:00:00

abstract：:Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several ...

journal_title：Cells

authors： Sher AA,Gao A,Coombs KM

更新日期：2020-03-26 00:00:00

abstract：:Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...

journal_title：Cells

authors： Raasakka A,Kursula P

更新日期：2020-02-18 00:00:00

abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...

journal_title：Cells

authors： Zonta F,Borgo C,Quezada Meza CP,Masgras I,Rasola A,Salvi M,Pinna LA,Ruzzene M

更新日期：2021-01-18 00:00:00

abstract：:Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...

journal_title：Cells

authors： Largeot A,Pagano G,Gonder S,Moussay E,Paggetti J

更新日期：2019-05-13 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...

journal_title：Cells

authors： Anel A,Gallego-Lleyda A,de Miguel D,Naval J,Martínez-Lostao L

更新日期：2019-02-12 00:00:00