Abstract：
:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have historically focused on morphological characterizations, but BG have also been implicated in viral antigen processing which suggests that they can serve a function in antiviral immunity. This study focused on investigating proteins that could be involved in BG formation to further characterize their structure using transmission electron microscopy (TEM). Here, we report a critical role for the protein annexin A2 (anxA2) in the proper formation of BG structures. When anxA2 expression is downregulated, langerin expression decreases, cytoplasmic BG are nearly ablated, and the presence of malformed BG-like structures increases. Furthermore, in the absence of anxA2, we found langerin was no longer localized to BG or BG-like structures. Taken together, these results indicate an essential role for anxA2 in facilitating the proper formation of BG.
journal_name
Cellsjournal_title
Cellsauthors
Thornton SM,Samararatne VD,Skeate JG,Buser C,Lühen KP,Taylor JR,Da Silva DM,Kast WMdoi
10.3390/cells9040974subject
Has Abstractpub_date
2020-04-15 00:00:00issue
4issn
2073-4409pii
cells9040974journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060604
更新日期：2019-06-17 00:00:00
abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081815
更新日期：2020-07-31 00:00:00
abstract：:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120271
更新日期：2018-12-13 00:00:00
abstract：:The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080920
更新日期：2019-08-17 00:00:00
abstract：:Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020359
更新日期：2020-02-04 00:00:00
abstract：:Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030599
更新日期：2020-03-03 00:00:00
abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121530
更新日期：2019-11-27 00:00:00
abstract：:The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn, hypoxic conditions. Hypoxia has been associated with poor clinical out...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040992
更新日期：2020-04-16 00:00:00
abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091097
更新日期：2019-09-17 00:00:00
abstract：:The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030723
更新日期：2020-03-15 00:00:00
abstract：:SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon transcriptional coactivation. Given the amplified expression of SRC-3 in ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101278
更新日期：2019-10-19 00:00:00
abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010009
更新日期：2020-12-22 00:00:00
abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020358
更新日期：2020-02-04 00:00:00
abstract：:Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWA...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010246
更新日期：2020-01-18 00:00:00
abstract：:Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in p...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010060
更新日期：2019-12-24 00:00:00
abstract：:Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8040346
更新日期：2019-04-12 00:00:00
abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071706
更新日期：2020-07-16 00:00:00
abstract：:The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleuki...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051311
更新日期：2020-05-25 00:00:00
abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071697
更新日期：2020-07-15 00:00:00
abstract：:Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112399
更新日期：2020-11-02 00:00:00
abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081811
更新日期：2020-07-30 00:00:00
abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020122
更新日期：2019-02-03 00:00:00
abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091919
更新日期：2020-08-19 00:00:00
abstract：:Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bac...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020273
更新日期：2020-01-22 00:00:00
abstract：:White adipose tissue (WAT) lipolysis contributes to energy balance during fasting. Lipolysis can proceed by the sequential hydrolysis of triglycerides (TGs) by adipose triglyceride lipase (ATGL), then of diacylglycerols (DGs) by hormone-sensitive lipase (HSL). We showed that the combined genetic deficiency of ATGL and...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050395
更新日期：2019-04-29 00:00:00
abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040808
更新日期：2020-03-27 00:00:00
abstract：:Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070714
更新日期：2019-07-13 00:00:00
abstract：:The zygote is defined as a diploid cell resulting from the fusion of two haploid gametes. Union of haploid male and female pronuclei in many animals occurs through rearrangements of the microtubule cytoskeleton into a radial array of microtubules known as the sperm aster. The sperm aster nucleates from paternally-deri...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020505
更新日期：2020-02-23 00:00:00
abstract：:Chronic inflammation and abnormalities in Toll-like receptor (TLR) signaling pathways are associated with major depressive disorder (MDD). Our previous work reported that impaired negative regulators for the TLR pathways are associated with MDD. This study aimed to assess the association between the severity of depres...
journal_title：Cells
pub_type： 临床试验,杂志文章
doi：10.3390/cells8070647
更新日期：2019-06-27 00:00:00
abstract：:In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061543
更新日期：2020-06-25 00:00:00
