Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.

abstract：:We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S. typhimurium A1-R was demonstrated in vivo and vitro using several malignant cell lines including melanoma, sarcoma, glioma, breast, pancreat...

journal_title：Cells

authors： Murakami T,Hiroshima Y,Miyake K,Kiyuna T,Endo I,Zhao M,Hoffman RM

更新日期：2019-06-16 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...

journal_title：Cells

authors： Smialek MJ,Ilaslan E,Sajek MP,Swiercz A,Janecki DM,Kusz-Zamelczyk K,Wozniak T,Kotecki M,Handschuh L,Figlerowicz M,Jaruzelska J

更新日期：2020-04-16 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...

journal_title：Cells

authors： Huaman J,Naidoo M,Zang X,Ogunwobi OO

更新日期：2019-06-20 00:00:00

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...

journal_title：Cells

authors： Ji W,Rivero F

更新日期：2016-06-14 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...

journal_title：Cells

authors： Romeo-Guitart D,Casas C

更新日期：2020-03-27 00:00:00

abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...

journal_title：Cells

authors： Olea-Flores M,Zuñiga-Eulogio M,Tacuba-Saavedra A,Bueno-Salgado M,Sánchez-Carvajal A,Vargas-Santiago Y,Mendoza-Catalán MA,Pérez Salazar E,García-Hernández A,Padilla-Benavides T,Navarro-Tito N

更新日期：2019-09-24 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis. We report here on its involvement in cellular reprogramming from fibroblasts to induced pluripotent stem cells, ...

journal_title：Cells

authors： Divvela SSK,Nell P,Napirei M,Zaehres H,Chen J,Gerding WM,Nguyen HP,Gao S,Brand-Saberi B

更新日期：2019-06-02 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...

journal_title：Cells

authors： Lee HS,Vancamelbeke M,Verstockt S,Wilms T,Verstockt B,Sabino J,Ferrante M,Vermeire S,Cleynen I

更新日期：2020-07-28 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00

abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

journal_title：Cells

authors： Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

更新日期：2019-05-08 00:00:00

abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...

journal_title：Cells

authors： Riboni L,Abdel Hadi L,Navone SE,Guarnaccia L,Campanella R,Marfia G

更新日期：2020-02-01 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...

journal_title：Cells

authors： Kim YH,Cho KA,Lee HJ,Park M,Shin SJ,Park JW,Woo SY,Ryu KH

更新日期：2020-01-15 00:00:00

abstract：:The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...

journal_title：Cells

authors： Bouvet M,Blondeau JP,Lezoualc'h F

更新日期：2019-11-29 00:00:00

abstract：:Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...

journal_title：Cells

authors： Kim W,Lee S,Seo D,Kim D,Kim K,Kim E,Kang J,Seong KM,Youn H,Youn B

更新日期：2019-09-18 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00

abstract：:Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...

journal_title：Cells

authors： Damanti CC,Gaffo E,Lovisa F,Garbin A,Di Battista P,Gallingani I,Tosato A,Pillon M,Carraro E,Mascarin M,Elia C,Biffi A,Bortoluzzi S,Mussolin L

更新日期：2021-01-08 00:00:00

abstract：:There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...

journal_title：Cells

authors： Harrell CR,Jovicic N,Djonov V,Arsenijevic N,Volarevic V

更新日期：2019-12-11 00:00:00

abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In t...

journal_title：Cells

authors： Taguchi YH,Wang H

更新日期：2018-12-05 00:00:00

abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...

journal_title：Cells

authors： Agranovsky A

更新日期：2021-01-07 00:00:00

abstract：:The Hippo pathway is a cellular signalling network, which plays major roles in organ homeostasis and development[...]. ...

journal_title：Cells

authors： Hansen CG

更新日期：2019-09-30 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have ...

journal_title：Cells

authors： Khavari B,Cairns MJ

更新日期：2020-08-05 00:00:00

abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...

journal_title：Cells

authors： Zhang L,Chen X,Yin J

更新日期：2019-09-06 00:00:00

abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...

journal_title：Cells

authors： Lapitz A,Arbelaiz A,O'Rourke CJ,Lavin JL,Casta A,Ibarra C,Jimeno JP,Santos-Laso A,Izquierdo-Sanchez L,Krawczyk M,Perugorria MJ,Jimenez-Aguero R,Sanchez-Campos A,Riaño I,Gónzalez E,Lammert F,Marzioni M,Macias RIR,Marin

更新日期：2020-03-14 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00