Cellular Stress Responses in Radiotherapy.

abstract：:The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant genomic diversity data for the future study of viral infections, aut...

journal_title：Cells

authors： Yao Y,Shi L,Yu J,Liu S,Tao Y,Shi L

更新日期：2019-07-12 00:00:00

abstract：:Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastom...

journal_title：Cells

authors： Karatsai O,Shliaha P,Jensen ON,Stasyk O,Rędowicz MJ

更新日期：2020-09-30 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00

abstract：:Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-rel...

journal_title：Cells

authors： Treeck O,Schüler-Toprak S,Ortmann O

更新日期：2020-10-26 00:00:00

abstract：:Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in p...

journal_title：Cells

authors： Yun CW,Kim HJ,Lim JH,Lee SH

更新日期：2019-12-24 00:00:00

abstract：:: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...

journal_title：Cells

authors： Anel A,Gallego-Lleyda A,de Miguel D,Naval J,Martínez-Lostao L

更新日期：2019-02-12 00:00:00

abstract：OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...

journal_title：Cells

authors： Ichise Y,Saegusa J,Tanaka-Natsui S,Naka I,Hayashi S,Kuroda R,Morinobu A

更新日期：2020-07-14 00:00:00

abstract：:Increasing evidence suggests that metabolic alterations may be etiologically linked to neurodegenerative disorders such as Parkinson's disease (PD) and in particular empathizes the possibility of targeting mitochondrial dysfunctions to improve PD progression. Under different pathological conditions (i.e., cardiac and ...

journal_title：Cells

authors： Piccirillo S,Magi S,Preziuso A,Castaldo P,Amoroso S,Lariccia V

更新日期：2020-09-06 00:00:00

abstract：:Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...

journal_title：Cells

authors： Sulima SO,Kampen KR,De Keersmaecker K

更新日期：2019-03-11 00:00:00

abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...

journal_title：Cells

authors： Bécot A,Pardossi-Piquard R,Bourgeois A,Duplan E,Xiao Q,Diwan A,Lee JM,Lauritzen I,Checler F

更新日期：2020-05-12 00:00:00

abstract：:Lupus flares when genetically predisposed people encounter exogenous agents such as infections and sun exposure and drugs such as procainamide and hydralazine, but the mechanisms by which these agents trigger the flares has been unclear. Current evidence indicates that procainamide and hydralazine, as well as inflamma...

journal_title：Cells

authors： Richardson B

更新日期：2019-02-05 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...

journal_title：Cells

authors： Lång A,Lång E,Bøe SO

更新日期：2019-08-14 00:00:00

abstract：:A triplet repeat expansion leading to transcriptional silencing of the FMR1 gene results in fragile X syndrome (FXS), which is a common cause of inherited intellectual disability and autism. Phenotypic variation requires personalized treatment approaches and hampers clinical trials in FXS. We searched for microRNA (mi...

journal_title：Cells

authors： Putkonen N,Laiho A,Ethell D,Pursiheimo J,Anttonen AK,Pitkonen J,Gentile AM,de Diego-Otero Y,Castrén ML

更新日期：2020-01-24 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...

journal_title：Cells

authors： Ferko M,Andelová N,Szeiffová Bačová B,Jašová M

更新日期：2019-11-17 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV patients live longer. Deposition of beta-amyloid (Aβ), a hallmark of Alzheimer's disease (AD), has been observed in subjects with HIV-associat...

journal_title：Cells

authors： Kodidela S,Gerth K,Haque S,Gong Y,Ismael S,Singh A,Tauheed I,Kumar S

更新日期：2019-08-24 00:00:00

abstract：:Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll-/-) exhibit elevated tissue levels of MAGs in association with res...

journal_title：Cells

authors： Dione N,Lacroix S,Taschler U,Deschênes T,Abolghasemi A,Leblanc N,Di Marzo V,Silvestri C

更新日期：2020-12-17 00:00:00

abstract：:Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...

journal_title：Cells

authors： Bovolenta LA,Pinhal D,Acencio ML,Oliveira AC,Moxon S,Martins C,Lemke N

更新日期：2020-07-22 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...

journal_title：Cells

authors： Aguilera MO,Delgui LR,Romano PS,Colombo MI

更新日期：2018-10-10 00:00:00

abstract：:Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen synthesis. The eff...

journal_title：Cells

authors： Matilla L,Arrieta V,Jover E,Garcia-Peña A,Martinez-Martinez E,Sadaba R,Alvarez V,Navarro A,Fernandez-Celis A,Gainza A,Santamaria E,Fernandez-Irigoyen J,Rossignol P,Zannad F,Lopez-Andres N

更新日期：2020-07-10 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1-5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its vasoconstrictor effects. We aimed to separate the beneficial and potentially de...

journal_title：Cells

authors： Wafa D,Koch N,Kovács J,Kerék M,Proia RL,Tigyi GJ,Benyó Z,Miklós Z

更新日期：2020-07-24 00:00:00

abstract：:In response to inflammatory stimuli, immune cells reconfigure their metabolism and bioenergetics to generate energy and substrates for cell survival and to launch immune effector functions. As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and ...

journal_title：Cells

authors： Meyers AK,Zhu X

更新日期：2020-07-30 00:00:00

abstract：:Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...

journal_title：Cells

authors： Hong CT,Chen KY,Wang W,Chiu JY,Wu D,Chao TY,Hu CJ,Chau KD,Bamodu OA

更新日期：2020-03-17 00:00:00

abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...

journal_title：Cells

authors： Bot I,Velden DV,Bouwman M,Kröner MJ,Kuiper J,Quax PHA,de Vries MR

更新日期：2020-03-12 00:00:00

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyc...

journal_title：Cells

authors： Karwowski BT

更新日期：2020-02-12 00:00:00