Abstract：
:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process called immunosenescence, giving rise to a chronic inflammatory status of the organism, with a decreased ability to counteract antigens. The obvious result of this process is a reduced defence capacity. Currently, there is evidence that some pathogens are able to accelerate the immunosenescence process for their own benefit. Although to date numerous reports show the autophagy⁻senescence relationship, or the connection between pathogens with autophagy or senescence, the link between the three actors remains unexplored. In this review, we have summarized current knowledge about important issues related to aging, senescence, and autophagy.
journal_name
Cellsjournal_title
Cellsauthors
Aguilera MO,Delgui LR,Romano PS,Colombo MIdoi
10.3390/cells7100162subject
Has Abstractpub_date
2018-10-10 00:00:00issue
10issn
2073-4409pii
cells7100162journal_volume
7pub_type
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