Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.

abstract：:Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor cells with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition and stemness potential, and this heterogeneity can hinder their characteriza...

journal_title：Cells

authors： Casciaro F,Zia S,Forcato M,Zavatti M,Beretti F,Bertucci E,Zattoni A,Reschiglian P,Alviano F,Bonsi L,Follo MY,Demaria M,Roda B,Maraldi T

更新日期：2021-01-15 00:00:00

abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...

journal_title：Cells

authors： Cheng CL,Yang SC,Lai CY,Wang CK,Chang CF,Lin CY,Chen WJ,Lin PY,Wu HC,Ma N,Lu FL,Lu J

更新日期：2020-07-16 00:00:00

abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...

journal_title：Cells

authors： Chen X,Egly C,Riley AM,Li W,Tewson P,Hughes TE,Quinn AM,Obukhov AG

更新日期：2014-04-04 00:00:00

abstract：:During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...

journal_title：Cells

authors： Plesner T,van de Donk N,Richardson PG

更新日期：2020-02-06 00:00:00

abstract：:Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization. CatS is overexpressed in many solid cancers, and overall, it appears to promote an im...

journal_title：Cells

authors： Fuchs N,Meta M,Schuppan D,Nuhn L,Schirmeister T

更新日期：2020-09-02 00:00:00

abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

journal_title：Cells

authors： Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

更新日期：2020-07-15 00:00:00

abstract：:The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn, hypoxic conditions. Hypoxia has been associated with poor clinical out...

journal_title：Cells

authors： Vito A,El-Sayes N,Mossman K

更新日期：2020-04-16 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...

journal_title：Cells

authors： Nally FK,De Santi C,McCoy CE

更新日期：2019-06-05 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

journal_title：Cells

authors： Rolot M,O'Sullivan TE

更新日期：2020-02-01 00:00:00

abstract：:Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several ...

journal_title：Cells

authors： Sher AA,Gao A,Coombs KM

更新日期：2020-03-26 00:00:00

abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...

journal_title：Cells

authors： Zonta F,Borgo C,Quezada Meza CP,Masgras I,Rasola A,Salvi M,Pinna LA,Ruzzene M

更新日期：2021-01-18 00:00:00

abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...

journal_title：Cells

authors： Bolívar S,Navarro X,Udina E

更新日期：2020-09-20 00:00:00

abstract：:Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-rel...

journal_title：Cells

authors： Treeck O,Schüler-Toprak S,Ortmann O

更新日期：2020-10-26 00:00:00

abstract：:The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...

journal_title：Cells

authors： Terry MI,Pérez-Sanz F,Navarro PJ,Weiss J,Egea-Cortines M

更新日期：2019-08-17 00:00:00

abstract：:In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...

journal_title：Cells

authors： Tournier BB,Tsartsalis S,Ceyzériat K,Garibotto V,Millet P

更新日期：2020-08-21 00:00:00

abstract：:Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...

journal_title：Cells

authors： Konno T,Melo EP,Chambers JE,Avezov E

更新日期：2021-01-25 00:00:00

abstract：:The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleuki...

journal_title：Cells

authors： Balaphas A,Meyer J,Perozzo R,Zeisser-Labouebe M,Berndt S,Turzi A,Fontana P,Scapozza L,Gonelle-Gispert C,Bühler LH

更新日期：2020-05-25 00:00:00

abstract：:In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as ...

journal_title：Cells

authors： Poovathumkadavil P,Jagla K

更新日期：2020-06-25 00:00:00

abstract：:The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut glioma, limiting the discovery of new effective chemotherapeutic agen...

journal_title：Cells

authors： Dao Trong P,Jungwirth G,Yu T,Pusch S,Unterberg A,Herold-Mende C,Warta R

更新日期：2020-06-03 00:00:00

abstract：:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...

journal_title：Cells

authors： Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MM

更新日期：2019-12-17 00:00:00

abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...

journal_title：Cells

authors： Papiewska-Pająk I,Krzyżanowski D,Katela M,Rivet R,Michlewska S,Przygodzka P,Kowalska MA,Brézillon S

更新日期：2020-06-30 00:00:00

abstract：:Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

journal_title：Cells

authors： Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

更新日期：2019-06-30 00:00:00

abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

journal_title：Cells

authors： Fields GB

更新日期：2019-08-27 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...

journal_title：Cells

authors： Samak M,Hinkel R

更新日期：2019-11-27 00:00:00

abstract：:Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a, TAC5-c, ...

journal_title：Cells

authors： Patra MC,Achek A,Kim GY,Panneerselvam S,Shin HJ,Baek WY,Lee WH,Sung J,Jeong U,Cho EY,Kim W,Kim E,Suh CH,Choi S

更新日期：2020-07-09 00:00:00

abstract：:Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...

journal_title：Cells

authors： Sousa L,Pankonien I,Clarke LA,Silva I,Kunzelmann K,Amaral MD

更新日期：2020-07-02 00:00:00

abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

journal_title：Cells

authors： Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

更新日期：2020-02-26 00:00:00

abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...

journal_title：Cells

authors： Mahli A,Seitz T,Freese K,Frank J,Weiskirchen R,Abdel-Tawab M,Behnam D,Hellerbrand C

更新日期：2019-04-17 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

journal_title：Cells

authors： Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

更新日期：2020-09-03 00:00:00