Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells.

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

journal_title：Cells

authors： Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

更新日期：2020-02-24 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...

journal_title：Cells

authors： Merckx G,Hosseinkhani B,Kuypers S,Deville S,Irobi J,Nelissen I,Michiels L,Lambrichts I,Bronckaers A

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...

journal_title：Cells

authors： Cammalleri M,Dal Monte M,Amato R,Lapi D,Bagnoli P

更新日期：2020-09-09 00:00:00

abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...

journal_title：Cells

authors： Guo ZH,Yi HC,You ZH

更新日期：2019-08-09 00:00:00

abstract：:The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...

journal_title：Cells

authors： Bublitz K,Böckmann S,Peters K,Hinz B

更新日期：2020-10-15 00:00:00

abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...

journal_title：Cells

authors： Monteonofrio L,Valente D,Rinaldo C,Soddu S

更新日期：2019-11-05 00:00:00

abstract：:The turnip Brassica rapa has important economic value and represents a good model system to study gene function in crop plants. ERF/AP2 transcription factors are a major group of proteins that are often involved in regulating stress-responses and developmental programs. Some ERF/AP2 proteins are targets of CULLIN3-bas...

journal_title：Cells

authors： Mooney S,Al-Saharin R,Choi CM,Tucker K,Beathard C,Hellmann HA

更新日期：2019-04-10 00:00:00

abstract：:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...

journal_title：Cells

authors： Huguet F,Flynn S,Vagnarelli P

更新日期：2019-07-07 00:00:00

abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...

journal_title：Cells

authors： Khan S,Ricciardelli C,Yool AJ

更新日期：2021-01-22 00:00:00

abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...

journal_title：Cells

authors： Lakatos Z,Lőrincz P,Szabó Z,Benkő P,Kenéz LA,Csizmadia T,Juhász G

更新日期：2019-07-24 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual...

journal_title：Cells

authors： Bylino OV,Ibragimov AN,Shidlovskii YV

更新日期：2020-07-12 00:00:00

abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...

journal_title：Cells

authors： Riboni L,Abdel Hadi L,Navone SE,Guarnaccia L,Campanella R,Marfia G

更新日期：2020-02-01 00:00:00

abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...

journal_title：Cells

authors： Umair M,Alfadhel M

更新日期：2019-12-09 00:00:00

abstract：:Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...

journal_title：Cells

authors： BeLow M,Osipo C

更新日期：2020-09-29 00:00:00

abstract：:Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell's ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial ...

journal_title：Cells

authors： Zhou Z,Austin GL,Young LEA,Johnson LA,Sun R

更新日期：2018-11-23 00:00:00

abstract：:A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...

journal_title：Cells

authors： Tröger J,Hoischen C,Perner B,Monajembashi S,Barbotin A,Löschberger A,Eggeling C,Kessels MM,Qualmann B,Hemmerich P

更新日期：2020-06-01 00:00:00

abstract：:The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...

journal_title：Cells

authors： Tang BL

更新日期：2018-06-14 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...

journal_title：Cells

authors： Reddy PH,Oliver DM

更新日期：2019-05-22 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00

abstract：:Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...

journal_title：Cells

authors： Natarajan U,Venkatesan T,Radhakrishnan V,Samuel S,Rathinavelu A

更新日期：2018-12-22 00:00:00

abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...

journal_title：Cells

authors： Dimitrova-Shumkovska J,Krstanoski L,Veenman L

更新日期：2020-04-02 00:00:00

abstract：:Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...

journal_title：Cells

authors： Dubois V,Staels B,Lefebvre P,Verzi MP,Eeckhoute J

更新日期：2020-09-28 00:00:00

abstract：:Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...

journal_title：Cells

authors： Sharko AC,Lim CU,McDermott MSJ,Hennes C,Philavong KP,Aiken T,Tatarskiy VV,Roninson IB,Broude EV

更新日期：2021-01-12 00:00:00