Abstract:
:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.
journal_name
Cellsjournal_title
Cellsauthors
Huguet F,Flynn S,Vagnarelli Pdoi
10.3390/cells8070687subject
Has Abstractpub_date
2019-07-07 00:00:00issue
7issn
2073-4409pii
cells8070687journal_volume
8pub_type
杂志文章,评审相关文献
Cells文献大全abstract::TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081847
更新日期:2020-08-06 00:00:00
abstract::Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102185
更新日期:2020-09-28 00:00:00
abstract::Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122667
更新日期:2020-12-11 00:00:00
abstract::In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there has been a great deal of progress in the implementation of EpCAM-based CTC detection technol...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081836
更新日期:2020-08-05 00:00:00
abstract::Non-human primates (NHP) are important surrogate models for late preclinical development of advanced therapy medicinal products (ATMPs), including induced pluripotent stem cell (iPSC)-based therapies, which are also under development for heart failure repair. For effective heart repair by remuscularization, large numb...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061349
更新日期:2020-05-29 00:00:00
abstract::Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112525
更新日期:2020-11-23 00:00:00
abstract::The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010030
更新日期:2020-12-27 00:00:00
abstract::Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081831
更新日期:2020-08-04 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091068
更新日期:2019-09-11 00:00:00
abstract::Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111396
更新日期:2019-11-06 00:00:00
abstract::Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081899
更新日期:2020-08-13 00:00:00
abstract::Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050389
更新日期:2019-04-28 00:00:00
abstract::Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020362
更新日期:2020-02-04 00:00:00
abstract::One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7080107
更新日期:2018-08-14 00:00:00
abstract::P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101286
更新日期:2019-10-21 00:00:00
abstract::Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030592
更新日期:2020-03-02 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081887
更新日期:2020-08-12 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanisms involved in the neurodegenerative process in ALS have been found, ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020381
更新日期:2020-02-07 00:00:00
abstract::Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040870
更新日期:2020-04-02 00:00:00
abstract::Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080768
更新日期:2019-07-24 00:00:00
abstract::The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122580
更新日期:2020-12-02 00:00:00
abstract::Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102176
更新日期:2020-09-27 00:00:00
abstract::Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010079
更新日期:2019-12-28 00:00:00
abstract::Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020390
更新日期:2020-02-07 00:00:00
abstract::Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in order to stimulate cel...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010171
更新日期:2020-01-09 00:00:00
abstract::In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010102
更新日期:2019-12-31 00:00:00
abstract::Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed. It is also known to be linked with several aspects of tumor malignancy in some types of human tumors, including invasion, metastasis, and cancer stemness. However, there are few reports on the expression of dog PDPN (dPDPN) in ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051136
更新日期:2020-05-05 00:00:00
abstract::Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070696
更新日期:2019-07-10 00:00:00
abstract::The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells9030526
更新日期:2020-02-25 00:00:00
abstract::Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear. Low levels of ROS and enhanced antioxidant defenses are shown to contribute to increasing radioresistance. However, the role of Nrf2-Keap1-Bach1 signaling in the radio...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010083
更新日期:2021-01-06 00:00:00