The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies.

Abstract:

:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.

journal_name

Cells

journal_title

Cells

authors

Huguet F,Flynn S,Vagnarelli P

doi

10.3390/cells8070687

subject

Has Abstract

pub_date

2019-07-07 00:00:00

issue

7

issn

2073-4409

pii

cells8070687

journal_volume

8

pub_type

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